A5100322901- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Cardiac electrophysiology and arrhythmias
- Pneumonia and Respiratory Infections
- Sodium Intake and Health
- Vaccine Coverage and Hesitancy
- Apelin-related biomedical research
- Tracheal and airway disorders
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Child and Adolescent Health
- Healthcare Systems and Reforms
- Ion Transport and Channel Regulation
- Protein Structure and Dynamics
- Health disparities and outcomes
- Global Health Care Issues
- Neuroscience and Neuropharmacology Research
- Renal and Vascular Pathologies
- Spinal Cord Injury Research
- Enzyme Structure and Function
- Lipid metabolism and disorders
- Wnt/β-catenin signaling in development and cancer
- Nuclear Receptors and Signaling
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
Weifang Medical University
2016-2023
Ningxia Medical University General Hospital
2022
Ningxia Medical University
2022
Shanxi Medical University
2018
Oita University
2009-2018
The University of Texas Southwestern Medical Center
2015
Howard Hughes Medical Institute
2015
Beijing Friendship Hospital
2012
Capital Medical University
2012
Significance Here we show that angiopoietin-like protein 3 (ANGPTL3) plays a major role in the trafficking of energy substrates to either storage or oxidative tissues response food intake. During fasting, adipose tissue releases fatty acids into circulation for uptake by tissues. After feeding, flow is reversed and replenished. In mice lacking ANGPTL3, from was markedly reduced after refeeding. Triglyceride stores were maintained increasing glucose converting it triglycerides. Thus, ANGPTL3...
Men have shorter rate-corrected QT intervals (QTc) than women, especially at the period of adolescence or later. The aim this study was to elucidate long-term effects testosterone on cardiac excitability parameters including electrocardiogram (ECG) and potassium channel current. Testosterone shortened in ECG castrated male rats, not immediately after, but day 2 Expression Kv7.1 (KCNQ1) mRNA significantly upregulated by cardiomyocytes female rats. Short-term application without effect delayed...
We have previously demonstrated that ANG II inhibits ROMK-like small-conductance K channels (SK) in the cortical collecting duct from rats on a K-deficient diet (KD) (35). In present study, we examined role of angiotensin type 1 receptor (AT(1)R) mediating effect restriction secretion. confirmed previous finding increased superoxide anion level, c-Src expression, and phosphorylation both p38 extracellular signal-regulated kinase mitogen-activated protein (MAPK) renal cortex outer medulla....
Full-length (pro)renin receptor (fPRR), a research hotspot of the renin-angiotensin system (RAS), plays serious role in kidney injury. However, relationship between fPRR and advanced oxidation protein product (AOPP) remains largely unexplored. This study was aimed at exploring effect fPRR, especially its 28 kDa soluble form called PRR (sPRR), AOPP-induced oxidative stress HK-2 cells, renal proximal tubular epithelial cell line. Incubation cells with 100 μg/ml AOPP resulted significant...
Pneumococcal diseases (PDs) are serious threats to child health. Although vaccination is one of the most effective ways prevent these diseases, pneumococcal coverage rate still relatively low in China.This study investigated factors associated with 13-valent conjugate vaccine (PCV13) hesitancy parents under an innovative immunization strategy. This found that 29.7% participants hesitated vaccinate their children against PCV13 and main reasons for were individual group influences.This can...
Blood pressure variability (BPV) is associated with cardiovascular and all-cause mortality, has been demonstrated in dialysis patients, but poorly studied remains controversial non-dialysis chronic kidney disease (CKD) patients. We investigated the effect of short-term BPV on prognosis this population. A total 245 stage 1-4 CKD patients 24-h ambulatory blood recordings were recruited. was evaluated by standard deviation, coefficient variation, variation independent mean, respectively. All...
Pneumococcal diseases (PDs) pose a serious health threat to children. Vaccination is the most cost-effective intervention prevent PDs, but pneumococcal vaccines coverage among children low in China.This study investigated willingness of children's caregivers have their vaccinated with under an innovative policy offer 1-dose 13-valent conjugate at no charge families. The research found that 70.51% were willing infants receive and reducing cost may increase caregivers' willingness.This first...
Objective To evaluate the effects of early tracheostomy and late on prognosis patients with cervical spinal cord injury, so as to provide evidence based guidance for timing tracheostomy. Methods Relevant literatures studying in injury were searched PubMed, Embase, Medline, Cochrane Library, Chinese Biological Medical Literature database (CBM), China National Knowledge Infrastructure (CNKI), VIP journal time range from establishment March 2018. The retrieved articles screened according...
Abstract Objective This study evaluated developmental stages and trends of Total Healthcare Expenditure (THE) 18 provinces in China. We explored characteristics different development during healthcare expenditure, to provide scientific reference for China's policy making regional planning.Methods Firstly, curve fitting parameter estimation using SPSS21 software were carried out the Logistic function model, then three-point or four-point method was applied estimate value saturation K. Finally...