A5064911554- Effects of Radiation Exposure
- Ultrasound and Hyperthermia Applications
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Berberine and alkaloids research
- Phagocytosis and Immune Regulation
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Cancer therapeutics and mechanisms
- Radiation Therapy and Dosimetry
- Mitochondrial Function and Pathology
- Dental materials and restorations
- Cancer Research and Treatments
- Circular RNAs in diseases
- Plant-based Medicinal Research
- Esophageal Cancer Research and Treatment
- Burn Injury Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Radiation Dose and Imaging
Midwestern University
2021-2025
Shenzhen University
2023-2024
First Affiliated Hospital of Fujian Medical University
2009-2024
Fujian Medical University
2009-2024
Hebei Medical University
2015-2024
Fourth Hospital of Hebei Medical University
2015-2024
Zhengzhou Central Hospital
2024
Medical College of Wisconsin
2012-2023
South China Normal University
2022-2023
First Affiliated Hospital Zhejiang University
2023
Abstract Background Pyroptosis is a form of programmed cell death involved in the pathophysiological progression hypoxic pulmonary hypertension (HPH). Emerging evidence suggests that N6-methyladenosine (m6A)-modified transcripts long noncoding RNAs (lncRNAs) are important regulators participate many diseases. However, whether m6A modified lncRNAs can regulate pyroptosis HPH remains unexplored. Methods The expression levels FENDRR artery endothelial cells (HPAECs) were detected by using...
The NIAID Radiation and Nuclear Countermeasures Program is developing medical agents to mitigate the acute delayed effects of radiation that may occur from a radionuclear attack or accident. To date, most such countermeasures have been developed for single organ injuries. Angiotensin converting enzyme (ACE) inhibitors used radiation-induced lung, skin, brain, renal injuries in rats. ACE also reported decrease normal tissue complication oncology patients. In current study, authors rat...
This study is aimed to elucidate the mechanisms underlying role of miR-485-5p in small cell lung cancer (SCLC). The expression were quantified with real time quantitative PCR and it was found that level lower SCLC tissues than normal tissues. In cultured lines, overexpression reduced proliferation, migration, invasion vitro, whereas knockdown performed contrary. FLOT2 obviously upregulated negatively correlated Overexpression significantly inhibited protein flotillin-2 (FLOT2) cells....
Our long-term goal is to use angiotensin converting enzyme (ACE) inhibitors mitigate the increase in lung collagen synthesis that induced by irradiation lung, which could result from accidental exposure or radiological terrorism. Rats (WAG/RijCmcr) were given a single dose of 13 Gy (dose rate 1.43 Gy/min) X-irradiation thorax. Three structurally-different ACE inhibitors, captopril, enalapril and fosinopril provided drinking water beginning 1 week after irradiation. survived acute pneumonitis...
The NIH/NIAID initiated a countermeasure program to develop mitigators for radiation-induced injuries from radiological attack or nuclear accident. We have previously characterized and demonstrated mitigation of single organ injuries, such as radiation pneumonitis, pulmonary fibrosis nephropathy by angiotensin converting enzyme (ACE) inhibitors. Our current work extends this research examine the potential mitigating multiple dysfunctions occurring in same irradiated rats. Using total body...
Our goal is to develop lisinopril as a mitigator of delayed effects acute radiation exposure in the National Institute Allergy and Infectious Diseases program for countermeasures. Published studies demonstrated mitigation by adult rats. However, juvenile or old rats beyond their reproductive lifespans have never been tested. Since no preclinical models were available these special populations, appropriate rat developed test after irradiation. Juvenile (42-d-old, prepubertal) female male...
The extracellular matrix of dentin contains macromolecules biological value that make it a natural source for the prospection novel smart biomaterials. Here, we described development an injectable thermosensitive hydrogel resulting from blending insoluble and chitosan. extrudability gelation parameters prehydrogel were optimized by varying concentration individual components. Three-dimensional constructs fabricated upon injection into custom-made molds, followed incubation at 37 °C....
ABSTRACT Objectives With the increasing incorporation of digital workflows into daily procedures dental schools, it becomes essential to assess competence new generations dentists provide best care when using these technologies. The aim this retrospective study was evaluate survivability monolithic lithium disilicate (LiDi) restorations prepared and delivered by predoctoral students. primary variable investigated service time restorations, that is, were in clinical function, encompassing...
Victims of a radiological attack or nuclear accident may receive high-dose, heterogeneous exposures from radiation to the chest that lead lung damage. Our goal is develop countermeasures mitigate such injuries. We used WAG/RijCmcr rats receiving 13 Gy whole thorax induce pulmonary fibrosis within 210 days. The angiotensin converting enzyme (ACE) inhibitor enalapril was evaluated as mitigator these injuries at two doses (18 and 36 mg/m2/day) 8 schedules: starting 7, 35, 70, 105 140 days...
To study the mechanisms of death following a single lethal dose thoracic radiation, WAG/RijCmcr (Wistar) rats were treated with 15 Gy to whole thorax and followed until they morbid or sacrificed for invasive assays at 6 weeks. Lung function was assessed by breathing rate arterial oxygen saturation. structure evaluated histologically. Cardiac examined echocardiography. The frequency characteristics pleural effusions determined. Morbidity from radiation occurred in all 5 8 weeks after...
Abstract The goal of this study was to develop rat models partial body irradiation with bone-marrow sparing (leg-out PBI) test medical countermeasures (MCM) both acute radiation syndrome (ARS) and delayed effects exposure (DEARE) under the FDA animal rule. leg-out PBI were developed in female male WAG/RijCmcr rats at doses 12.5–14.5 Gy. Rats received supportive care consisting fluids antibiotics. Gastrointestinal ARS (GI-ARS) assessed by lethality d 7 diarrhea scoring 10. Differential blood...
In the event of a radiological accident or terrorist attack, whole- partial-body exposure can injure lungs. To simulate such an incident, we used single fraction total-body irradiation (TBI) whole-thoracic to induce pneumonitis pulmonary fibrosis, respectively, in rat model. The superoxide dismutase and catalase mimetic EUK-207 was given by subcutaneous injection (20 mg/kg/day, 5 days per week, once daily) starting at 7 after stopping before developed. After TBI, morbidity increase breathing...
Our goal is to develop countermeasures for pulmonary injury following unpredictable events such as radiological terrorism or nuclear accidents. We have previously demonstrated that captopril, an angiotensin converting enzyme (ACE) inhibitor, more effective than losartan, type-1 receptor blocker, in mitigating radiation-pneumopathy a relevant rodent model. In the current study we determined dose modifying factors (DMFs) of captopril mitigation parameters radiation pneumonitis. used whole...
Our goal is to develop minimally invasive biomarkers for predicting radiation-induced lung injury before symptoms develop. Currently, there are no that can predict radiation pneumonitis. Radiation damage the whole a serious risk in nuclear accidents or radiologic terrorism. previous studies have shown single dose of 15 Gy x-rays thorax causes severe pneumonitis rats by 6–8 wk. We also developed mitigator and fibrosis be started as late 5 wk after radiation. <b>Methods:</b> used 2 functional...
Abstract We used a rat model of whole thorax x-ray irradiation to profile the microRNA (miRNA) in lung and blood up 4 weeks after radiation. MiRNA from normal irradiated Wistar lungs were analyzed by next-generation sequencing changes radiation identified differential deRNA-seq 1, 2, 3 irradiation. The average total reads/library was 2,703,137 with mean 88% mapping genome. Detailed profiles 100 most abundant miRNA are described. upregulation miRNA, miR-144-5p, miR-144-3p, miR-142-5p...
Myeloperoxidase (MPO) anti-neutrophil cytoplasm autoantibody (ANCA)-associated vasculitis commonly causes life-threatening pulmonary alveolar hemorrhage or fibrosis. Only a limited number of candidate gene variants have been explored, but hitherto, are not widely confirmed. In the present study, we investigated importance energy homeostasis associated (Enho) mutations and adropin deficiency in development MPO-ANCA lung injury.We analyzed peripheral blood mononuclear cells from 152 unrelated...