A5001851791- Eicosanoids and Hypertension Pharmacology
- Pancreatic and Hepatic Oncology Research
- Nitric Oxide and Endothelin Effects
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Blood Pressure and Hypertension Studies
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Heart Rate Variability and Autonomic Control
- Liver Disease Diagnosis and Treatment
- Esophageal and GI Pathology
- Renal cell carcinoma treatment
- Electrolyte and hormonal disorders
- Pancreatitis Pathology and Treatment
- Receptor Mechanisms and Signaling
- Neuroendocrine Tumor Research Advances
- Diet, Metabolism, and Disease
- Sodium Intake and Health
- Chemotherapy-induced organ toxicity mitigation
- Esophageal Cancer Research and Treatment
- Chronic Kidney Disease and Diabetes
- Liver Disease and Transplantation
- Pharmacogenetics and Drug Metabolism
- Alcohol Consumption and Health Effects
- Circadian rhythm and melatonin
Aligarh Muslim University
2025
Khyber Medical University
2025
University of Arkansas for Medical Sciences
2025
Medical College of Wisconsin
2014-2024
University of Missouri Health System
2024
University of Missouri
2024
Dhaka Medical College and Hospital
2024
Medical College of Wisconsin Cancer Center
2021
Mayo Clinic Health System
2021
Froedtert Hospital
2016-2020
This paper reports findings from a study of maternal mortality in Matlab, Bangladesh during the 1976-85 period. The employed multiple-step procedure to identify maternity-related deaths all reproductive-aged women within area this A total 387 were identified, resulting an overall ratio 5.5 per 1,000 live births. introduction family planning program half Matlab led moderate but significant reduction rates, relative comparison area. appears have been primarily due number pregnancies treatment...
Nephrotoxicity severely limits the use of anticancer drug cisplatin. Oxidative stress, inflammation, and endoplasmic reticulum (ER) stress contribute to cisplatin-induced nephrotoxicity. We developed novel orally active epoxyeicosatrienoic acid (EET) analogs investigated their prophylactic effect in nephrotoxicity rats. Cisplatin-induced was manifested by increases blood urea nitrogen, plasma creatinine, urinary N-acetyl-β-(d)-glucosaminidase activity, kidney injury molecule 1,...
The proximal nephron reabsorbs 60% to 70% of the fluid and sodium most filtered bicarbonate via Na/H exchanger 3. Enhanced transport is implicated in hypertension. Our findings show that a fructose-enriched diet causes salt sensitivity. We hypothesized fructose stimulates luminal exchange activity sensitizes tubule angiotensin II. was measured rat tubules as rate intracellular pH (pHi) recovery fluorescent units/s. Replacing 5 mmol/L glucose with increased pHi (1.8±0.6 units/s; P<0.02; n=8)....
Epoxyeicosatrienoic acids (EETs) contribute to haemodynamics, electrolyte homoeostasis and blood pressure regulation, leading the concept that EETs can be therapeutically targeted for hypertension. In present study, multiple structural EET analogues were synthesized based on pharmacophore vasodilator structure-activity studies. Four with 91-119% vasodilatory activity in isolated bovine coronary artery (EC50: 0.18-1.6 μM) identified studied blood-pressure-lowering Two which COOH group at...
One facet of precision medicine is the use tumor molecular profiling to guide chemotherapeutic selection. We conducted first prospective clinical trial neoadjuvant therapy in patients with operable pancreatic ductal adenocarcinoma (PDAC). hypothesized that more effective systemic would prevent disease progression during and, therefore, allow undergo surgery.In resectable and borderline (BLR) PDAC, consisted immunocytochemical staining pretreatment endoscopic ultrasound-guided fine needle...
Hydrogen sulfide (H(2)S), an endogenous vasoactive agent, is produced by cystathionine γ-lyase (CGL) and β-synthase (CBS) enzymes. This study was conducted to evaluate the relative contribution of these enzymes in regulating systemic arterial pressure.Sprague-Dawley rats were chronically treated with CGL inhibitor, DL-propargylglycine (PAG, 37.5 mg/kg/day; intraperitoneally, i.p.) or CBS aminooxyacetic acid (AOA, 8.75 combination for 4 weeks effects on pressure (tail-cuff plethysmography)...
Salt-sensitive hypertension leads to kidney injury. The Dahl salt-sensitive hypertensive rat (Dahl SS) is a model of and progressive current set experimental studies evaluated the protective potential novel epoxyeicosatrienoic acid analog (EET-B) in SS hypertension. rats receiving high-salt diet were treated with EET-B (10 mg/kg per day) or vehicle drinking water for 14 days. Urine, plasma, tissue samples collected at end treatment protocol assess injury, oxidative stress, inflammation,...
Our goal is to develop lisinopril as a mitigator of delayed effects acute radiation exposure in the National Institute Allergy and Infectious Diseases program for countermeasures. Published studies demonstrated mitigation by adult rats. However, juvenile or old rats beyond their reproductive lifespans have never been tested. Since no preclinical models were available these special populations, appropriate rat developed test after irradiation. Juvenile (42-d-old, prepubertal) female male...
Objective: To explore the role of extracurricular activities in development leadership skills among undergraduate Doctor Physical Therapy students. Method: The cross-sectional study was conducted from March to October 2023 at Khyber Medical University and its affiliated institutes Peshawar, Pakistan, comprised students either gender aged least 18 years. Data collected using a pilot-tested questionnaire. analysed SPSS22. Results: Of 340 students, 231(67.9%) were females 109(32.1%) males....
Objectives/Goals: Radiation nephropathy results in morbidity and mortality patients receiving cancer treatment. In addition, low birth weight nephron number are associated with increased risk for chronic kidney disease. This study examined the development severity of radiation-induced renal hemodynamic dysfunction a mass mouse model. Methods/Study Population: Male mice (C57Bl/6, 8–12-weeks) were used to determine suitable radiation dose regimen. Mice subjected fractionated bilateral...
Cardiometabolic syndrome occurs with obesity and consists of pathophysiological factors that increase the risk for cardiovascular events. Soluble epoxide hydrolase inhibition (sEHi) is a novel therapeutic approach exerts renal protection. Although sEHi as promising, it could be more effective treatment cardiometabolic when combined peroxisome proliferator activated receptor γ (PPARγ) agonists. We hypothesized PPARγ agonist, rosiglitazone in combination (tAUCB) will provide synergistic...