A5020610603- Effects of Radiation Exposure
- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Glutathione Transferases and Polymorphisms
- Renal Transplantation Outcomes and Treatments
- Renin-Angiotensin System Studies
- Polyomavirus and related diseases
- Renal cell carcinoma treatment
- Hematopoietic Stem Cell Transplantation
- Renal Diseases and Glomerulopathies
- Radiation Dose and Imaging
- Eicosanoids and Hypertension Pharmacology
- Radiation Therapy and Dosimetry
- Organ Transplantation Techniques and Outcomes
- Blood Pressure and Hypertension Studies
- Renal and Vascular Pathologies
- Renal function and acid-base balance
- Parathyroid Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Chemotherapy-induced organ toxicity mitigation
- Electrolyte and hormonal disorders
- Organ Donation and Transplantation
- Genetic and Kidney Cyst Diseases
- Carcinogens and Genotoxicity Assessment
New York University
2021-2025
Hebrew University of Jerusalem
2025
VA NY Harbor Healthcare System
2024
Manhattan Psychiatric Center
2022
University of Maryland, Baltimore
2015-2021
Indiana University – Purdue University Indianapolis
2015-2019
Indiana University School of Medicine
2015-2019
Baltimore VA Medical Center
2015-2019
Medical College of Wisconsin
2007-2016
Veterans Health Administration
2016
Acquired cystic kidney disease (ACKD) is the result of cyst formation in failing kidney. It has become more common because increases retention patients' own kidneys, growth dialysis population, and survival long-term patients. We studied our chronic population for ACKD renal cancers, conducted a literature review cancer. analyzed patients from 1979 through 1989 native retention, undergoing their first transplant at center 1967 1989. Our those reports were characterized by age, sex, race,...
Distal urinary acidification abnormalities may arise from transepithelial voltage defects, permeability or proton-secretory but tests to determine the cellular mechanisms underlying secretory have not previously been reported. A patient with Sjogren's syndrome and distal renal tubular acidosis due a defect is described, whose kidney biopsy was examined by fluorescent immunocytochemistry an antibody M(r) 31,000 subunit of mammalian vacuolar H(+)-ATPase compared normal human kidney. Staining...
Background. The burden of chronic kidney disease (CKD) in sub-Saharan Africa is unknown. aim this study was to investigate the prevalence and risk factors associated with CKD Kinshasa, capital Democratic Republic Congo (DRC).
Treatment of BK virus (BKV) infection in renal transplant recipients remains controversial. This retrospective analysis evaluated efficacy and safety reducing immunosuppression without antiviral therapy.This single center included 24 patients diagnosed with viremia between September 2001 December 2003. Sixteen (66%) presented BKV nephritis eight (34%) evidence on biopsy.At time diagnosis, mean plasma DNA (copies/mL) was 460,409 (range 10,205-1,920,691). Mean doses reduction mycophenolate...
There is limited knowledge of Chronic Kidney Disease (CKD) among high risk populations, especially in the developing countries. We report our study testing for CKD at-risk subjects. In a cross-sectional study, 527 people from primary and secondary health care areas city Kinshasa were studied random sample out-patients with hypertension, diabetes, obesity, or HIV+. measured blood pressure (BP), glucose level, proteinuria, body mass index, estimated glomerular filtration rate (eGFR by MDRD...
A workshop entitled "Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate" (held in Rockville, MD, September 19, 2016) was organized by the Radiation Research Program Oncology Branch of Center for Cancer (CCR) National Institute (NCI), identify critical research areas directions that will advance understanding radiation-induced fibrosis (RIF) accelerate development strategies mitigate or treat it. Experts radiation biology, oncology related fields met prioritize key future...
The NIAID Radiation and Nuclear Countermeasures Program is developing medical agents to mitigate the acute delayed effects of radiation that may occur from a radionuclear attack or accident. To date, most such countermeasures have been developed for single organ injuries. Angiotensin converting enzyme (ACE) inhibitors used radiation-induced lung, skin, brain, renal injuries in rats. ACE also reported decrease normal tissue complication oncology patients. In current study, authors rat...
Polyoma virus infection is characterized by lymphocytic interstitial infiltrate in the kidney, and it mimics acute rejection. The purpose of this study to estimate renal allograft outcome with characterize infiltrates polyoma virus-infected allografts.Patients who had inclusions biopsies were identified. Other viral excluded immunohistochemistry. six cases compared definite rejection immunostaining for T B cells.There 10 infections transplant recipients. Immunosuppressants consisted...
The shortage of cadaver donors for kidney transplantation has prompted many centers to use kidneys from older donors. donor been associated with lower graft survival.United Network Organ Sharing data all adult cadaveric renal transplant recipients receiving between 1988 and 1994 (transplants, n=35,621) were analyzed further study this issue. All patients followed a minimum 1 year after transplantation. classified according age: group 1, 19-50 years; 2, 51-60 3, >60 years.The actuarial...
Until recently long-term renal toxicity has not been considered a major late complication of bone marrow transplantation (BMT). Late dysfunction described in pediatric population status post-BMT which was attributable to the radiation preparatory regimen. A thorough review adults with this type previously described. Fourteen 103 evaluable adult patients undergoing allogeneic (96) or autologous (7) transplantation, predominantly for leukemia and lymphomas, at Medical College Wisconsin...
Regarding the prevalence of chronic kidney disease in population, estimation glomerular filtration rate is importance. Creatinine-based formulas are thus useful as first step a prevention strategy. Several creatinine-based have been published. Among these, Cockcroft-Gault formula and Modification Diet Renal Disease (MDRD) study equation most used by physicians. The latter may be automatically reported laboratories has great success. However, these limitations. First, MDRD not applicable to...
It is known that angiotensin converting enzyme inhibitors (ACEIs) and II type-1 receptor blockers (ARBs) can be used to mitigate radiation-induced renal injury. However, for a variety of reasons, these previous results are not directly applicable the development agents mitigation injuries caused by terrorism-related radiation exposure. As part an effort develop animal model would fit requirements U.S. Food Drug Administration (FDA) "Animal Efficacy Rule", we designed new studies which...
Human genome-wide association studies have linked SH2B adaptor protein 3 ( SH2B3 , LNK ) to hypertension and renal disease, although little experimental investigation has been performed verify a role for in these pathologies. SH2B3, member of the family, is an intracellular that functions as negative regulator many signaling pathways, including inflammatory processes. To explore mechanistic link between hypertension, we targeted gene mutation on Dahl salt-sensitive (SS) rat genetic...
The threat of radiation exposure from warfare or accidents raises the need for appropriate animal models to study acute and chronic effects high dose rate exposure. goal this was assess late development fibrosis in multiple organs (kidney, heart, lung) survivors C57BL/6 mouse model hematopoietic-acute syndrome (H-ARS). Separate groups mice histological functional studies were exposed a single uniform total body between 8.53 8.72 Gy gamma Cs source studied 1-21 mo later. Blood urea nitrogen...
Nearly 50% of patients with multiple myeloma develop renal disease, most commonly from AKI caused by cast nephropathy. Development is associated poor 1-year survival and reduces the therapeutic options available to patients. There a great need for more effective therapies. Cast nephropathy interaction aggregation filtered free light chains Tamm–Horsfall protein causing intratubular obstruction damage. The key treating rapid lowering chains, because this correlates recovery. Newer...
Background. Over 12 000 bone marrow transplantations (BMT) are performed in the USA each year. This procedure is associated with significant morbidity including acute and chronic renal failure (CRF). CRF after BMT usually secondary to radiation nephropathy and/or cyclosporine (CsA) toxicity. Survival on dialysis therapy for patients poor transplantation may be a preferable form of renal‐replacement therapy.Methods. We report our experience 6 end‐stage disease (ESRD) following BMT: 4 as...