A5034148306- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Renal Diseases and Glomerulopathies
- COVID-19 Clinical Research Studies
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Acute Kidney Injury Research
- Pediatric Urology and Nephrology Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Global Maternal and Child Health
- Lipoproteins and Cardiovascular Health
- Peripheral Artery Disease Management
- HIV/AIDS drug development and treatment
- Pharmacological Effects and Toxicity Studies
- Neurological and metabolic disorders
- Healthcare Systems and Practices
- Kidney Stones and Urolithiasis Treatments
- Organ Donation and Transplantation
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Renal Transplantation Outcomes and Treatments
- HIV-related health complications and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Acute Ischemic Stroke Management
University of Kinshasa
2016-2025
Université Protestante au Congo
2025
Ministry of Public Health
2016
Université Catholique de Bukavu
2014
University of Liège
2009-2010
Medical College of Wisconsin
2010
The accuracy of estimation kidney function with the use routine metabolic tests, such as measurement serum creatinine level, has been controversial. European Kidney Function Consortium (EKFC) developed a creatinine-based equation (EKFC eGFRcr) to estimate glomerular filtration rate (GFR) rescaled level (i.e., is divided by median among healthy persons control for variation related differences in age, sex, or race). Whether cystatin C-based EKFC would increase estimated GFR unknown. We used...
A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This neither validated outside USA nor compared with European Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in cohorts.Standardized creatinine measured glomerular filtration rate (GFR) from EKFC cohorts (n = 13 856 including 6031 individuals external validation cohort), France 4429, 964 Black Europeans), Brazil 100) Africa 508)...
There is limited knowledge of Chronic Kidney Disease (CKD) among high risk populations, especially in the developing countries. We report our study testing for CKD at-risk subjects. In a cross-sectional study, 527 people from primary and secondary health care areas city Kinshasa were studied random sample out-patients with hypertension, diabetes, obesity, or HIV+. measured blood pressure (BP), glucose level, proteinuria, body mass index, estimated glomerular filtration rate (eGFR by MDRD...
Apolipoprotein-L1 (
Context and objective In the estimation of glomerular filtration rate (GFR), ethnicity is an important determinant. However, all existing equations have been built solely from Caucasian Afro-American populations they are potentially inaccurate for estimating GFR in African populations. We therefore evaluated performance different estimated (eGFR) predicting measured (mGFR). Methods a cross-sectional study, 93 healthy adults were randomly selected general population Kinshasa, Democratic...
Despite the growing incidence of acute kidney injury (AKI) worldwide, there is little data on burden and outcomes AKI in intensive care unit (ICU) low resource settings. The present study assessed its impact mortality ICU Kinshasa (Democratic Republic Congo). In a prospective cohort study, 476 consecutive critically ill patients (mean age 52 years, 57 % male) were screened for presence seven from January 1st to March 30th, 2015. Serum creatinine was measured by enzymatic method (Cobas C111...
We describe a case series of histoplasmosis caused by Histoplasma capsulatum var. duboisii during July 2011-January 2014 in Kimpese, Democratic Republic the Congo. Cases were confirmed histopathology, immunohistochemistry, and reverse transcription PCR. All patients HIV negative. Putative sources for pathogen cellar bats guano fertilizer exploitation.
Background: Worldwide, the proportion of hypertensive patients with controlled blood pressure is poor. Knowledge on hypertension has been recognised as a major determinant uncontrolled hypertension.Aim: This study aimed to determine factors associated knowledge and control among in Kimpese Health Zone, Democratic Republic Congo (DRC).Setting: Six health facilities Zone were selected.Methods: was an analytical cross-sectional from May 2021 December 2021. Information socio-demographic...
Background: Renal complications of sickle cell disease are becoming very common, and patients generally do not respond to conventional nephroprotective treatments. Among the drugs used, hydroxyurea (HU) seems have produced good results according some studies. This molecule has yet been evaluated in DR Congo for this purpose. To evaluate albuminuria glomerular filtration rate (GFR) after 9 months HU treatment a population children with incipient nephropathy. Methods: was an open clinical...
<title>Abstract</title> Background Despite current interest in creatinine-based equations for estimating glomerular filtration rate, the evaluation of creatinine reference intervals remains relevant. The present study aimed to establish such from a healthy Congolese adult. Methods This was based on <italic>post-hoc</italic> data previous epidemiology conducted general population Kinshasa. Serum Creatinine measurement performed with enzymatic IDMS-traceable method. values being not normally...
Context and objective. Patients with COVID-19 admitted to intensive care sometimes require extra-renal purification (ERP) for various indications. However, the related data are paradoxically non-existent. The aim of present study was describe extent survival use ERP. Methods. This a historical cohort focusing on patients multipurpose unit Grand Hôpital de l'Est Ile-de-France, Meaux site, during period from March 2020 December 2021. Patient described by Kaplan-Meier curves, different curves...
Context and objective. The Democratic Republic of Congo (DRC) does not currently practice kidney transplantation, patients are referred to other countries for transplantation. Furthermore, post-kidney transplant follow-up in the DRC is suboptimal faces several challenges. present study aimed evaluate survival grafts recipients followed up Kinshasa. Methods. This cohort retrospective was conducted three hospitals Kinshasa/the included post-transplant selected between 2000 2020. Graft failure...
<i>Background:</i> Although screening programs for chronic kidney disease (CKD) may be of great value, these are not yet implemented in the Democratic Republic Congo. This study focused on proteinuria and examined its prevalence terms number needed to screen different risk factors CKD. Such knowledge would guide utility population prevent end-stage renal disease. <i>Methods:</i> A cross-sectional survey was conducted Kinshasa Second World Kidney Day. sample 3,018...
Uncontrolled hypertension remains an important issue in daily clinical practice worldwide. Although the majority of patients are treated primary care, most data on blood pressure control originate from population-based studies or secondary healthcare.The aim this study was to evaluate frequency uncontrolled and associated risk factors among hypertensive followed at care facilities Kinshasa, capital city Democratic Republic Congo.A sample 298 seen healthcare facilities, 90 men 208 women, aged...
Sickle cell anemia (SCA) is considered a major risk factor for renal complications. The main goal of this study was to determine the frequency macroalbuminuria and microalbuminuria in Congolese children <18 years age suffering from identify associated factors.The cross-sectional completed 150 hemoglobin-SS (77 boys 73 girls). Microalbuminuria defined by urine albumin:creatinine ratio 30-299 mg/g.The mean group 8.8 ± 4.3 (range 2-18). found 27 (18%). In multivariate logistic regression, only...
Microalbuminuria is a marker of early kidney disease and high cardiovascular risk in various populations, including HIV positive patients. However, the diagnostic value qualitative (dipstick) proteinuria burden microalbuminuria patients living sub-Saharan Africa are relatively unclear. In cross-sectional study, 235 HIV- outpatients were screened for 3 HIV-clinics Bukavu. A spot urine sample from each subject was tested both by dipstick albumin-creatinine-ratio (ACR) assay. The performance...
Although the lungs remain main target of SARS-CoV-2, other organs, such as kidneys, can be affected, which has a negative impact on outcomes COVID-19 patients. previous studies kidney disease in reported mainly SARS-CoV-2-induced tubular and interstitial injury, there is growing evidence coming out Africa glomerular involvement, especially collapsing glomerulopathy seen particularly people African descent. We report case revealed by acute injury new onset full blown nephrotic syndrome black...
Sub-Saharan Africans exhibit a higher frequency of chronic kidney disease (CKD) than other populations. In this study, we sought to determine the apolipoprotein L1 (APOL1) genotypes in hypertension-attributed CKD Kinshasa, Democratic Republic Congo. We performed case–control study identifying 162 subjects: 79 with and 83 controls living Kinshasa who were genotyped for APOL1 risk variants between July 2013 November 2016. selected control subjects from general population matched them cases...
Oxidative stress is thought to be involved in the pathogenesis of microalbuminuria Sickle cell anemia (SCA). Antioxidant enzymes such as glutathione peroxidase (GPx) and Cu-Zn superoxide dismutase (SOD) may play an important protective role. This study aimed evaluate association between albuminuria these two antioxidant enzymes.We consecutively recruited Steady state children aged 2 18 years old with established diagnosis homozygous SCA hospitals Kinshasa/DR Congo. The relationship Urinary...