A5073434416- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Chronic Lymphocytic Leukemia Research
- Trypanosoma species research and implications
- Lipoproteins and Cardiovascular Health
- Global Maternal and Child Health
- Lysosomal Storage Disorders Research
- HIV/AIDS drug development and treatment
- Malaria Research and Control
- HIV-related health complications and treatments
- Prenatal Screening and Diagnostics
- HIV/AIDS Research and Interventions
- Acute Lymphoblastic Leukemia research
- Neonatal Health and Biochemistry
- Pediatric Urology and Nephrology Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- Pregnancy and Medication Impact
- Acute Kidney Injury Research
- Urinary Tract Infections Management
- Lymphoma Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
University of Kinshasa
2015-2025
KU Leuven
2018-2023
Pediatrics and Genetics
2021
Centre Hospitalier Universitaire de Bordeaux
2015
Apolipoprotein-L1 (
Published data on acute renal failure in children from the Democratic Republic of Congo are rare. The objective this study was to review clinical manifestations, aetiologies and outcome hospitalized with failure.A retrospective at Pediatric Nephrology Unit University Hospital Kinshasa carried out.Fifty-six were eligible. There 31 boys (55.4%) 25 girls (44.6%) a sex ratio 1.24. median age 6.7 years (range 1-13 years). Fever (80.3%), oligo-anuria (73.2%), jaundice (67.9%) common presentation....
In the Democratic Republic of Congo (DRC), acute kidney injury (AKI) contributes to high rate child mortality owing conjunction poverty, deficiency qualified health-care providers in pediatric nephrology, and lack dialysis programs. We aimed describe recent experience first peritoneal (PD) program DRC. This is a retrospective cohort study on epidemiology, clinical features outcomes children admitted from January 2018 2019 at University Hospital Kinshasa for AKI treated with PD. PD started by...
Primary hyperoxaluria (PH) is a rare disorder with significant morbidity and mortality if left untreated. Given the rarity, global inequities in diagnostics treatment are expected. Recently introduced RNA interference therapeutics (RNAi) have dramatically changed outcome for PH patients, potentially disproportionately affecting low-resource regions. Understanding these disparities crucial implementing measures, ensuring equitable healthcare access patients worldwide. This study aims to...
To determine the prevalence of nocturnal enuresis in children Kinshasa Democratic Republic Congo. In all, 506 questionnaires were sent to parents aged 6-12 years randomly selected from four primary schools Kinshasa, The questionnaire was designed collect information about and factors associated with enuresis. A total 415 (82.0%) correctly completed. this series, 109 identified as which 50 boys 56 girls (p > 0.05). Factors deep sleep, young age familial history < Only 11% patients have been...
Sickle cell anemia is a chronic illness associated with important nonmedical complications. The prevalence of depression and its clinical profile among Congolese children suffering from sickle disease are unknown. We therefore conducted cross-sectional study in between 8 17 years. main goal this was to describe characteristics population living Kinshasa, the Democratic Republic Congo. survey patients attending 2 referral centers. Children aged years old were evaluated by semistructured...
Sickle cell anemia (SCA) is considered a major risk factor for renal complications. The main goal of this study was to determine the frequency macroalbuminuria and microalbuminuria in Congolese children <18 years age suffering from identify associated factors.The cross-sectional completed 150 hemoglobin-SS (77 boys 73 girls). Microalbuminuria defined by urine albumin:creatinine ratio 30-299 mg/g.The mean group 8.8 ± 4.3 (range 2-18). found 27 (18%). In multivariate logistic regression, only...
The prevalence of sickle cell disease (SCD) is extremely high in the Democratic Republic Congo (DRC). Despite this our midst, there has been no report on clinical features pediatric population suffering from malaria midst.A retrospective survey records Department Paediatrics University Hospital Kinshasa, Congo, was done for period 1998–2008. For 10 years studied, 108 children with SCD were reviewed and data those who developed during admission retrieved analyzed.Of 90 homozygous malaria,...
Neonatal screening for sickle cell anaemia is not common practice in the Democratic Republic of Congo, and we determined prevalence children with unknown electrophoresis haemoglobin anaemia.A cross-sectional study was conducted four hospitals country's capital Kinshasa.We screened 807 patients (Hb < 6 g/dL) disease. The overall mean age at presentation 42.7 months ± 29.7 months, most (76.3%) were less than five years age, a peak incidence seven to 36 (45%). median first transfusion 29 (range...
In the Democratic Republic of Congo, incidence sickle cell anemia (SCA) is estimated to affect 30,000 40,000 neonates per year. However, there paucity data on acute clinical manifestations in children. these circumstances, it difficult develop a health care policy for an adequate management patients. This was seven years' retrospective study children admitted with crisis Department Pediatrics University Hospital Kinshasa, Congo. A total 108 patients were identified as having SCA. There 56...
Oxidative stress is thought to be involved in the pathogenesis of microalbuminuria Sickle cell anemia (SCA). Antioxidant enzymes such as glutathione peroxidase (GPx) and Cu-Zn superoxide dismutase (SOD) may play an important protective role. This study aimed evaluate association between albuminuria these two antioxidant enzymes.We consecutively recruited Steady state children aged 2 18 years old with established diagnosis homozygous SCA hospitals Kinshasa/DR Congo. The relationship Urinary...
Summary Clinical and genetic factors have been reported as influencing the development of sickle cell nephropathy (SCN). However, such data remain limited in paediatric population. In this cross‐sectional study, we enrolled 361 disease children from Democratic Republic Congo. Participants were genotyped for beta (β)‐globin gene, apolipoprotein L1 ( APOL1 ) risk variants, haem oxygenase‐1 HMOX1 GT‐dinucleotide repeats. As markers kidney damage, albuminuria, hyperfiltration decreased estimated...
Neonatal screening for sickle cell anemia is not a common practice in the Democratic Republic of Congo (DRC). Children with disease are known to have an increased risk infections. We conducted pilot study determine prevalence during episodes severe infection. A prospective was from July 2009 2011. The sites included four public hospitals at Kinshasa, DRC. population selected source using three-stage sampling. total 247 children infection were consecutively recruited and screened disease....
Abstract Aim Glomerular hyperfiltration is an early marker of sickle cell nephropathy and can lead to microalbuminuria renal failure. Our aim was identify the associated risk factors, as these could be preventative importance. Methods We recruited 150 children with anaemia (SCA), aged two 18 years living in Kinshasa, Democratic Republic Congo. Hyperfiltration were defined estimated glomerular filtration rate less than 140 mL/min/1.73 m² albumin creatinine ratio between 30 299 mg/g,...
Abstract Aim The care of children with resistant nephrotic syndrome ( NS ) in the D emocratic R epublic C ongo is compromised by resource deficiencies that range from inadequate healthcare budgets, to scarce laboratory facilities and inconsistent drug supplies. aim this study was describe clinical profile management Kinshasa, country's capital its largest city. Methods We retrospectively reviewed medical records 62 patients a diagnosis , who were seen P aediatric N ephrology U nit at...
Apolipoprotein L1 (APOL1) high-risk genotypes (HRG), G1 and G2, increase the risk of various non-diabetic kidney diseases in African population. To date, precise mechanisms by which APOL1 variants induce injury on podocytes other cells remain unclear. Trying to unravel these mechanisms, most studies have used animal or cell models created gene editing. We developed characterised conditionally immortalised human podocyte lines derived from urine a donor carrying HRG G2/G2. Following induction...
Background: Information on presentation and outcome of pediatric non-Hodgkin's lymphoma is limited from Africa. The demographic characteristics, distribution different subtypes were noted compared with published reports other parts the world. Methods: study was conducted in Kinshasa, Democratic Republic Congo between January 2002 December 2012. Results: A total 63 cases retrospectively analyzed. This cohort represents largest series presented sub-Saharan Median age 8.7±3.6 years. There 43...
Cardiovascular (CV) disease is the leading cause of mortality in patients with end-stage kidney (ESKD). The aim present study was to determine whether Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) could be an independent predictor CV events and all-cause black African haemodialysis patients.We carried out a prospective cohort all consecutive hemodialysis (HD) between August 2016 July 2020, admitted six centers Kinshasa, Democratic Republic Congo. Independent determinants plasma...