A5077928918- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Acute Kidney Injury Research
- Inflammatory mediators and NSAID effects
- Potassium and Related Disorders
- Chronic Kidney Disease and Diabetes
- Eicosanoids and Hypertension Pharmacology
- Liver Disease and Transplantation
- Renal and Vascular Pathologies
- Ion channel regulation and function
- Hormonal Regulation and Hypertension
- Dialysis and Renal Disease Management
- Organ Donation and Transplantation
- Blood Pressure and Hypertension Studies
- Muscle and Compartmental Disorders
- Renin-Angiotensin System Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Central Venous Catheters and Hemodialysis
- Bone health and treatments
- Nitric Oxide and Endothelin Effects
- Pharmacological Effects and Toxicity Studies
- Bone health and osteoporosis research
- Metabolism and Genetic Disorders
- Parathyroid Disorders and Treatments
Shaare Zedek Medical Center
2006-2019
The University of Texas Health Science Center at San Antonio
2000-2016
Pediatric Nephrology of Alabama
2009
Murphy Oil Corporation (United States)
1978-2003
South Texas Veterans Health Care System
2003
Clinical Research Services
2000-2002
Audie L. Murphy Memorial VA Hospital
1982-1988
University of Miami
1980-1987
San Francisco VA Medical Center
1984
University of Colorado Denver
1982
The circulating concentrations of 1,25-dihydroxyvitamin D and 24,25-dihydroxyvitamin are abnormally low in patients with chronic renal failure (CRF). To determine the importance substrate (25-hydroxyvitamin D) concentration this phenomenon, five end stage disease treated hemodialysis were given 25-hydroxyvitamin D3 (25-OH-D3) orally for 4 weeks. serum 25-OH-D3 increased from a mean (±SEM) 26 ± 5 ng/ml immediately before therapy to maximum 108 weeks after beginning administration 25-OH-D3....
The administration of vasodilating agents such as bradykinin and acetylcholine cause an increase in urinary sodium excretion. Yet the mechanisms involved this natriuretic effect are not clear. Recent studies with another renal vasodilator, secretin have shown drug also causes a profound blood flow but without major changes To attempt to delineate basis difference excretion these drugs, functional effects were compared at equivalent dose. Bradykinin increased from 222 342 ml/min, urine volume...
1. Since several lines of evidence have suggested that a diminution endogenous prostaglandins (PG) may participate in the pathogenesis variety disease states, it would be advantageous to develop therapeutic approaches augment prostaglandin synthesis. linoleic acid is readily converted arachidonic acid, we assessed effects administration on immunoassayable PGE and 6-oxo-PGF1α excretion as indices PGE2 PGI2 production. 2. Six normal subjects were studied twice: during seated control study an 8...
1. It has been suggested that endogenous renal prostaglandin E (PGE) constitutes a determinant of haemodynamics and sodium handling in patients with cirrhosis. We have accordingly assessed the effects augmenting prostaglandins on function. utilized water immersion to neck since previous studies demonstrated redistribution blood volume concomitant central hypervolaemia thus induced produces prompt marked augmentation PGE excretion normal man. 2. Thirteen cirrhotic were studied twice while...
The combined occurrence of hereditary nephritis with nerve deafness (Alport’s syndrome) and macrothrombocytopathic thrombocytopenia is very rare. authors have had the opportunity to study such a case in 20-year-old man who been followed since birth. clinical history, renal biopsy, platelet studies, autopsy findings are presented. pathologic well defined; however, hemostatic abnormalities hearing loss not characterized. In this paper, an attempt made clarify diverse functional morphologic...
The effects of epidermal growth factor (EGF) on intracellular calcium ([Ca 2+ ] i ) responses to the muscarinic agonist carbachol were studied in a human salivary cell line (HSY). Carbachol (10 −4 M)-stimulated [Ca mobilization was inhibited by 40% after 48-h treatment with 5 × 10 −10 M EGF. EGF also reduced carbachol-induced Ca -free medium and influx following repletion extracellular . Under conditions, thapsigargin, an inhibitor uptake internal stores, induced similar signals control...
Contrast-induced acute kidney injury (CI-AKI) is one of the leading causes hospital-acquired injury. Multiple clinical studies have proposed several preventive strategies.To examine efficacy sodium bicarbonate compared with chloride and oral N-acetylcysteine (NAC) for hydration after cardiac catheterization.We conducted a prospective, single-center trial. Patients chronic disease (CKD) stage III-IV undergoing catheterization were allocated to receive either an infusion 0.9% NAC or 154 mEq/L...
Recent studies have suggested that aldosterone has many effects in addition to its ability cause the kidney retain sodium. To test hypothesis can hypertension a manner does not involve renal sodium retention, we administered eplerenone, specific antagonist, oligo-anuric chronic hemodialysis patients who had HTN.220 underwent initial screening. Of these, 8 were followed for weeks and their blood pressure, weight, plasma potassium, levels renin activity recorded. After 4 week run period, each...
Preoperative anemia adversely affects outcomes of cardiothoracic surgery. However, in patients with CKD, treating to a target normal hemoglobin has been associated increased risk adverse cardiac and cerebrovascular events. We investigated the association between preoperative surgery CKD assessed whether there was level below which incidence surgical increases.This prospective observational study included adult stages 3-5 (eGFR<60 ml/min per 1.73 m(2)) undergoing from February 2000 January...
Acute renal failure may be caused by multiple conditions including those which are due to some direct hemodynamic or nephrotoxic insult. In considering the pathophysiology of these entities, it seems appropriate differentiate between initiating and maintenance phase disorder. former, ischemia and/or a effect given agent basis for underlying damage. phase, functional impairment is maintained number factors include persistent vasoconstriction, tubular obstruction, leakage filtrate across...