A5015394743- Effects of Radiation Exposure
- Glutathione Transferases and Polymorphisms
- Chemotherapy-induced cardiotoxicity and mitigation
- Ultrasound and Hyperthermia Applications
- Acute Kidney Injury Research
- Renin-Angiotensin System Studies
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Chemotherapy-induced organ toxicity mitigation
- Eicosanoids and Hypertension Pharmacology
- PARP inhibition in cancer therapy
- Vitamin C and Antioxidants Research
- Carcinogens and Genotoxicity Assessment
- Cancer, Hypoxia, and Metabolism
- Retinoids in leukemia and cellular processes
- Nitric Oxide and Endothelin Effects
- MRI in cancer diagnosis
- Electron Spin Resonance Studies
- Organ Transplantation Techniques and Outcomes
- Hematopoietic Stem Cell Transplantation
- Biochemical effects in animals
- Cardiac Imaging and Diagnostics
- Burn Injury Management and Outcomes
- Extracellular vesicles in disease
- Cardiac Ischemia and Reperfusion
Medical College of Wisconsin
2016-2025
Milwaukee VA Medical Center
2018-2023
Loma Linda University
2023
Froedtert Hospital
2022
Ochsner Medical Center
2015-2017
ID-FISH Technology (United States)
2015
Palmetto Hematology Oncology
2013
National Atmospheric Research Laboratory
2009
Tulane University
2005
Tulane Medical Center
2005
Abstract Background. Carcinoma of the larynx is most common cancer affecting head and neck region. In Northern Europe, early laryngeal almost universally treated by irradiation, but elsewhere it surgery. The main aim this study was to determine whether there any difference in survival between two therapeutic options. secondary assess speech voice quality a small, randomized sample patients from each treatment group. Methods. subjects investigated were 488 with T1–2, N0 squamous cell...
Purpose: To determine the impact of 10 Gy total body irradiation (TBI) or local thorax irradiation, a dose relevant to radiological terrorist threat, on lipid and liver profile, coronary microvasculature ventricular function.Materials methods: WAG/RijCmcr rats received TBI followed by bone marrow transplantation, irradiation. Age-matched, non-irradiated served as controls. The profile enzymes, vessel morphology, nitric oxide synthase (NOS) isoforms, protease activated receptor (PAR)-1...
Progressive, irreversible fibrosis is one of the most clinically significant consequences ionizing radiation on normal tissue. When applied to lungs, it leads a complication described as idiopathic pneumonia syndrome (IPS) and eventually organ fibrosis. For its high mortality, condition precludes treatment with doses radiation. There widespread interest understand pathogenetic mechanisms IPS find drugs effective in prevention development. This report summarizes our experience protective...
It is known that angiotensin converting enzyme inhibitors (ACEIs) and II type-1 receptor blockers (ARBs) can be used to mitigate radiation-induced renal injury. However, for a variety of reasons, these previous results are not directly applicable the development agents mitigation injuries caused by terrorism-related radiation exposure. As part an effort develop animal model would fit requirements U.S. Food Drug Administration (FDA) "Animal Efficacy Rule", we designed new studies which...
Our long-term goal is to use angiotensin converting enzyme (ACE) inhibitors mitigate the increase in lung collagen synthesis that induced by irradiation lung, which could result from accidental exposure or radiological terrorism. Rats (WAG/RijCmcr) were given a single dose of 13 Gy (dose rate 1.43 Gy/min) X-irradiation thorax. Three structurally-different ACE inhibitors, captopril, enalapril and fosinopril provided drinking water beginning 1 week after irradiation. survived acute pneumonitis...
The NIAID Radiation and Nuclear Countermeasures Program is developing medical agents to mitigate the acute delayed effects of radiation that may occur from a radionuclear attack or accident. To date, most such countermeasures have been developed for single organ injuries. Angiotensin converting enzyme (ACE) inhibitors used radiation-induced lung, skin, brain, renal injuries in rats. ACE also reported decrease normal tissue complication oncology patients. In current study, authors rat...
The NIH/NIAID initiated a countermeasure program to develop mitigators for radiation-induced injuries from radiological attack or nuclear accident. We have previously characterized and demonstrated mitigation of single organ injuries, such as radiation pneumonitis, pulmonary fibrosis nephropathy by angiotensin converting enzyme (ACE) inhibitors. Our current work extends this research examine the potential mitigating multiple dysfunctions occurring in same irradiated rats. Using total body...
Our goal is to develop lisinopril as a mitigator of delayed effects acute radiation exposure in the National Institute Allergy and Infectious Diseases program for countermeasures. Published studies demonstrated mitigation by adult rats. However, juvenile or old rats beyond their reproductive lifespans have never been tested. Since no preclinical models were available these special populations, appropriate rat developed test after irradiation. Juvenile (42-d-old, prepubertal) female male...
Radiation-induced lung injury is a major dose-limiting toxicity for thoracic radiation therapy patients. In experimental models, treatment with angiotensin converting enzyme (ACE) inhibitors mitigates pneumonitis; however, the mechanism of action not well understood. Here, we evaluate direct role ACE inhibition on immune cells.ACE expression and activity were determined in cell compartment irradiated adult rats after either high dose fractionated to right (5 fractions × 9 Gy) or single 13.5...
Victims of a radiological attack or nuclear accident may receive high-dose, heterogeneous exposures from radiation to the chest that lead lung damage. Our goal is develop countermeasures mitigate such injuries. We used WAG/RijCmcr rats receiving 13 Gy whole thorax induce pulmonary fibrosis within 210 days. The angiotensin converting enzyme (ACE) inhibitor enalapril was evaluated as mitigator these injuries at two doses (18 and 36 mg/m2/day) 8 schedules: starting 7, 35, 70, 105 140 days...
To study the mechanisms of death following a single lethal dose thoracic radiation, WAG/RijCmcr (Wistar) rats were treated with 15 Gy to whole thorax and followed until they morbid or sacrificed for invasive assays at 6 weeks. Lung function was assessed by breathing rate arterial oxygen saturation. structure evaluated histologically. Cardiac examined echocardiography. The frequency characteristics pleural effusions determined. Morbidity from radiation occurred in all 5 8 weeks after...
Abstract The goal of this study was to develop rat models partial body irradiation with bone-marrow sparing (leg-out PBI) test medical countermeasures (MCM) both acute radiation syndrome (ARS) and delayed effects exposure (DEARE) under the FDA animal rule. leg-out PBI were developed in female male WAG/RijCmcr rats at doses 12.5–14.5 Gy. Rats received supportive care consisting fluids antibiotics. Gastrointestinal ARS (GI-ARS) assessed by lethality d 7 diarrhea scoring 10. Differential blood...
Both experimental and clinical radiation nephropathy are typically progressive, evolving to kidney failure over weeks months. Other late injuries (spinal cord, lung) also progressive have no known specific antidote. Recent reports of the efficacy captopril in modifying injury lung prompted this trial treating established nephropathy. Six months after 15-27 Gy 12 fractions bilateral renal irradiation, 72 rats with blood urea nitrogen > 4.1 mmol/liter were started on (500 mg/liter) or drug...
Purpose: To characterize structural and functional injuries following a single dose of whole-thorax irradiation that might be survivable after nuclear attack/accident.