A5020694375- Breast Cancer Treatment Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Effects of Radiation Exposure
- Advanced Radiotherapy Techniques
- Cancer survivorship and care
- Cardiac Imaging and Diagnostics
- Nutrition and Health in Aging
- PARP inhibition in cancer therapy
- Electron Spin Resonance Studies
- Cancer-related cognitive impairment studies
- Radiation Therapy and Dosimetry
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Mitochondrial Function and Pathology
- Global Cancer Incidence and Screening
- Lung Cancer Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Advanced Breast Cancer Therapies
- Advanced MRI Techniques and Applications
- Breast Implant and Reconstruction
- Cardiovascular Function and Risk Factors
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer Treatment and Pharmacology
- Cancer, Hypoxia, and Metabolism
Washington University in St. Louis
2020-2025
Medical College of Wisconsin
2015-2024
Alvin J. Siteman Cancer Center
2021-2024
Hospital of the University of Pennsylvania
2023
Froedtert Hospital
2023
NRG Oncology
2022
Nestlé (France)
2020
Case Western Reserve University
2005-2018
University of Chicago
2018
The Ohio State University
2018
Abstract Cardiac radiotherapy (RT) may be effective in treating heart failure (HF) patients with refractory ventricular tachycardia (VT). The previously proposed mechanism of radiation-induced fibrosis does not explain the rapidity and magnitude which VT reduction occurs clinically. Here, we demonstrate hearts from RT that radiation achieve transmural within timeframe reduction. Electrophysiologic assessment irradiated murine reveals a persistent supraphysiologic electrical phenotype,...
Fasting strategies are under active clinical investigation in patients receiving chemotherapy. Prior murine studies suggest that alternate-day fasting may attenuate doxorubicin cardiotoxicity and stimulate nuclear translocation of transcription factor EB (TFEB), a master regulator autophagy lysosomal biogenesis. In this study, human heart tissue from with doxorubicin-induced failure demonstrated increased TFEB protein. mice treated doxorubicin, or viral transduction mortality impaired...
The NIAID Radiation and Nuclear Countermeasures Program is developing medical agents to mitigate the acute delayed effects of radiation that may occur from a radionuclear attack or accident. To date, most such countermeasures have been developed for single organ injuries. Angiotensin converting enzyme (ACE) inhibitors used radiation-induced lung, skin, brain, renal injuries in rats. ACE also reported decrease normal tissue complication oncology patients. In current study, authors rat...
Apolipoprotein M (ApoM) binds sphingosine-1-phosphate (S1P) and is inversely associated with mortality in human heart failure (HF). Here, we show that anthracyclines such as doxorubicin (Dox) reduce circulating ApoM mice humans, patients anthracycline-induced failure, heterozygosity increases Dox-induced mortality. In the setting of Dox stress, our studies suggest can help sustain myocardial autophagic flux a post-transcriptional manner, attenuate cardiotoxicity, prevent lysosomal injury.
Platelet endothelial cell adhesion molecule-1 (PECAM-1; CD31) is a 130-kDa member of the Ig superfamily that expressed on platelets and leukocytes highly enriched at cell-cell junctions. Previous studies showed this vascular signaling receptor functions to regulate platelet activation thrombosis, suppress apoptotic death, mediate transendothelial migration leukocytes, maintain integrity vasculature. Because systemic exposure bacterial endotoxin LPS triggers an acute inflammatory response...
Abstract Purpose: The standard treatment for organ-confined prostate cancer is surgery or radiation, and locally advanced typically treated with radiotherapy alone in combination androgen deprivation therapy. Here, we investigated whether Stat5a/b participates regulation of double-strand DNA break repair cancer, Stat5 inhibition may provide a novel strategy to sensitize radiotherapy. Experimental Design: was evaluated by comet clonogenic survival assays, followed assays specific homologous...
TPS613 Background: Approximately 50% of newly diagnosed breast cancers are stage 1, with the majority being ER/PR-positive, HER2-negative. Genomic assays such as Oncotype DX® have identified patients (pts) reduced risk distant metastasis and without benefit from chemotherapy added to endocrine therapy, freeing them excess toxicity. also recognized prognostic for in-breast recurrence (IBR) after BCS could similarly allow de-escalation adjuvant radiotherapy (RT). Reducing overtreatment is...
Radiation dose to the heart correlates with cardiac-related deaths and may partially diminish benefit of radiation for breast cancer. This study assessed current nationwide trends in heart-sparing techniques cancer radiation.In November 2017, an institutional review board-approved survey was sent oncologists United States. Questions demographics type frequency techniques. Data were analyzed using descriptive statistics χ2 tests.In total, 530 responses (13%) obtained. Most physicians had...
Radiation therapy is used in ~50% of cancer patients to reduce the risk recurrence and some cases improve survival. Despite these benefits, doses can be limited by toxicity multiple organs, including heart. The underlying causes biomarkers radiation-induced cardiotoxicity are currently unknown, prompting need for experimental models with inherent differences sensitivity resistance development cardiotoxicity. We have identified parental SS (Dahl salt-sensitive/Mcwi) rat strain a...