A5013864544- Cancer survivorship and care
- Nutrition and Health in Aging
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer-related cognitive impairment studies
- Exercise and Physiological Responses
- Effects of Radiation Exposure
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Cardiac Ischemia and Reperfusion
- PARP inhibition in cancer therapy
- Apelin-related biomedical research
- Diabetic Foot Ulcer Assessment and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mitochondrial Function and Pathology
- Cardiac electrophysiology and arrhythmias
- Radiation Therapy and Dosimetry
- Heart Rate Variability and Autonomic Control
- Acute Myocardial Infarction Research
- Immune cells in cancer
- Takotsubo Cardiomyopathy and Associated Phenomena
- Brain Metastases and Treatment
- Extracellular vesicles in disease
- MicroRNA in disease regulation
Washington University in St. Louis
2022-2024
Hospital of the University of Pennsylvania
2023
Alvin J. Siteman Cancer Center
2022
Virginia Commonwealth University
2017-2022
University of Alberta
2018
Apolipoprotein M (ApoM) binds sphingosine-1-phosphate (S1P) and is inversely associated with mortality in human heart failure (HF). Here, we show that anthracyclines such as doxorubicin (Dox) reduce circulating ApoM mice humans, patients anthracycline-induced failure, heterozygosity increases Dox-induced mortality. In the setting of Dox stress, our studies suggest can help sustain myocardial autophagic flux a post-transcriptional manner, attenuate cardiotoxicity, prevent lysosomal injury.
Coronary artery disease (CAD) is an immune-mediated in which CCR2 attracts classical, intermediate, and non-classical monocytes to the arterial intima where they differentiate macrophages. Balance between pro-inflammatory M1 anti-inflammatory M2 macrophages contributes CAD prevention. Moderate vigorous intensity physical activity (MVPA) elicits immune response reduces incidence of CAD, however, impact prior MVPA on monocyte subset expression macrophage polarization following acute exercise unknown.
Abstract Purpose: Among patients with breast cancer undergoing radiotherapy, posttreatment cardiovascular disease and worsened quality of life (QoL) are leading causes morbidity mortality. To overcome these negative radiotherapy effects, this prospective, randomized clinical trial pilots a 12-week Stay on Track exercise diet intervention for overweight nonmetastatic whole-breast radiotherapy. Experimental Design: The group (n = 22) participated in three personal dietary counseling sessions,...
Radiation therapy remains part of the standard care for breast, lung, and esophageal cancers. While radiotherapy improves local control survival, radiation-induced heart dysfunction is a common side effect thoracic radiotherapy. Cardiovascular can also result from non-therapeutic total body radiation exposures. Numerous studies have evaluated relationship between dose to cardiotoxicity, but relatively little known about whether there are differences based on biological sex in (RIHD).We male...
<div>AbstractPurpose:<p>Among patients with breast cancer undergoing radiotherapy, posttreatment cardiovascular disease and worsened quality of life (QoL) are leading causes morbidity mortality. To overcome these negative radiotherapy effects, this prospective, randomized clinical trial pilots a 12-week Stay on Track exercise diet intervention for overweight nonmetastatic whole-breast radiotherapy.</p>Experimental Design:<p>The group (<i>n</i> = 22)...
<p>Comparisons of cytokine levels at baseline, 3 months, and 6 months</p>
<p>Body composition and DEXA scan analysis at baseline, 3 months, 6 months</p>
<p>Patient demographics at baseline</p>
<p>Patient demographics at baseline</p>
<div>AbstractPurpose:<p>Among patients with breast cancer undergoing radiotherapy, posttreatment cardiovascular disease and worsened quality of life (QoL) are leading causes morbidity mortality. To overcome these negative radiotherapy effects, this prospective, randomized clinical trial pilots a 12-week Stay on Track exercise diet intervention for overweight nonmetastatic whole-breast radiotherapy.</p>Experimental Design:<p>The group (<i>n</i> = 22)...
<p>Supplementary Tables 1-3</p>
<p>FitBit activity levels. Percent change in average total steps per day (<b>A</b>), active minutes (<b>B</b>), and (<b>C</b>) the intervention group compared with their baselines. Total (<b>D</b>), (<b>E</b>), very (<b>F</b>) during baseline week control groups. Graphs show mean ± SE. *, <i>P</i> < 0.05.</p>
<p>Comparisons of resting metabolism and energy expenditure, metabolic biomarkers at baseline, 3 months, 6 months</p>
<p>Comparisons of resting metabolism and energy expenditure, metabolic biomarkers at baseline, 3 months, 6 months</p>
<p>Study timeline.</p>
<p>Comparisons of nutritional outcomes at baseline, 3 months, and 6 months</p>
<p>Comparisons of cytokine levels at baseline, 3 months, and 6 months</p>
<p>FitBit activity levels. Percent change in average total steps per day (<b>A</b>), active minutes (<b>B</b>), and (<b>C</b>) the intervention group compared with their baselines. Total (<b>D</b>), (<b>E</b>), very (<b>F</b>) during baseline week control groups. Graphs show mean ± SE. *, <i>P</i> < 0.05.</p>