A5100416724- Chronic Myeloid Leukemia Treatments
- Kruppel-like factors research
- 14-3-3 protein interactions
- Ureteral procedures and complications
- Renal cell carcinoma treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Plasma Applications and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Musculoskeletal pain and rehabilitation
- Cell Adhesion Molecules Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Birth, Development, and Health
- Spine and Intervertebral Disc Pathology
- Immune cells in cancer
- Infection Control and Ventilation
- Cerebrovascular and Carotid Artery Diseases
- Climate Change and Health Impacts
- Systemic Lupus Erythematosus Research
- Renal and related cancers
- Cardiovascular Health and Disease Prevention
- Immunotherapy and Immune Responses
- Colorectal Cancer Treatments and Studies
- Congenital Diaphragmatic Hernia Studies
- Click Chemistry and Applications
- 3D Printing in Biomedical Research
Chinese General Hospital College of Nursing and Liberal Arts
2025
Chinese People's Liberation Army
2022-2025
University of Chinese Academy of Sciences
2022-2024
Chinese Academy of Sciences
2019-2024
Technical Institute of Physics and Chemistry
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Wangjing Hospital of China Academy of Chinese Medical Sciences
2023-2024
Chongqing University
2022-2024
Central South University
2022-2023
Xiangya Hospital Central South University
2022-2023
Abstract Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5 + DM) is an autoimmune condition associated with rapidly progressive interstitial lung disease and high mortality. The aetiology pathogenesis of MDA5 DM are still largely unknown. Here we describe the immune signatures via single-cell RNA sequencing, flow cytometry multiplex immunohistochemistry in peripheral B T cells affected tissue samples from one patient. We find strong antibody-secreting cell CD8...
Hydrogels containing chondrocytes have exhibited excellent potential in regenerating hyaline cartilage. However, are vulnerable to dedifferentiation during vitro culture, leading fibrosis and mechanical degradation of newly formed It is proposed modulate cartilage formation via the developed chondrocyte pericellular matrix (PCM) -like scaffolds for first time, which S, M, L-sized fabricated by femtosecond laser maskless optical projection lithography (FL-MOPL) bovine serum albumin-glyceryl...
<title>Abstract</title> Teratomas are among the most common germ cell tumors found in children. They predominantly occur sacrococcygeal region and often spinal canal, whereas paravertebral teratomas very rare. Herein, we present a case of teratoma incidentally discovered an 11-year-old boy. The tumor was located between diaphragm, parietal pleura, ribs, intercostal muscles. Complete resection achieved using paramedian approach. Postoperative recovery uneventful, no residue or recurrence...
The nonreceptor tyrosine kinase c-ABL controls cell growth but its contributions in solid tumors are not fully understood. Here we report that the Polo-like PLK1, an essential mitotic regulator, is important downstream effector of regulating cervical cancer. interacted with and phosphorylated PLK1. Phosphorylation PLK1 by inhibited ubiquitination degradation enhanced activity, leading to cell-cycle progression tumor growth. Both were overexpressed carcinoma. Notably, phosphorylation...
Fish has received increasing attention because it induces IgE-meidated food allergy. Parvalbumin (PV) represents the major allergen of fish, and IgE cross-reactivity to PV in various teleost fish species been shown, while little information is available about allergens elesmobranch fish. In this study, two isoforms (named as PV-I PV-II) from red stingray (Dasyatis akajei) were purified homogeneity by a series procedures including ammonium sulfate precipitation column chromatographies...
Abstract Tumor-infiltrating PD-1hi dysfunctional CD8+ T cells have been identified in several tumors but largely unexplored breast cancer (BC). Here we aimed to extensively explore PD-1hiCD8+ BC, focusing on the triple-negative BC (TNBC) subtype. Flow cytometry was used study phenotypes and functions of T-cell subsets peripheral blood surgical specimens from treatment-naive patients. RNA-seq expression data generated dissect molecular features tumoral PD-1neg, PD-1lo cells. Further,...
Objectives We aimed to assess the dose–response association between weight gain from young middle adulthood and odds of metabolic syndrome, across body mass index (BMI) categories at adulthood. Methods Based on a national population-based screening project, middle-aged (35–64 years) participants who recalled age 25 years received standardized measurements were included. Multivariable adjusted restricted cubic splines logistic regression models applied. Results In total, 437,849 included...
Co-expression of erythropoietin (Epo) and receptor (EpoR) has been found in various non-hematopoietic cancers including hereditary sporadic renal cell carcinomas (RCC), but the Epo/EpoR autocrine paracrine mechanisms tumor progression have not yet identified. In this study, we used RNA interference method to down-regulate EpoR investigate function pathway human RCC cells. Epo co-expressed primary cancer cells 6 lines. signaling was constitutionally phosphorylated cells, 786-0 Caki-1...
The peripheral B cell compartment is heavily disturbed in systemic lupus erythematosus (SLE), but whether cells develop aberrantly the bone marrow (BM) largely unknown.
Abstract BACKGROUND: As the largest producer and consumer of freshwater fish in world, many people suffer from allergy for consuming China. However, allergen profiles are rarely known. RESULTS: Parvalbumins (PVs) white muscle silver carp ( Hypophthalmichthy molitrix ) were purified by ammonium sulfate fractionation column chromatography including DEAE‐Sepharose Superdex 75. Three PV isoforms—PV‐I, PV‐II, PV‐III—were obtained their molecular masses as estimated tricine–sodium dodecyl...
Abstract Telocytes had been identified as a peculiar stromal cell type implicated in tissue homeostasis and the development pathophysiology of diseases. Telocyte existed most organs tissues humans animals. However, few studies have examined telocytes ApoE gene deficient mice. In our studies, we verified existence, morphology immunohistochemical characteristics critical −/− Male adult mice were selected an experimental model. Immunohistochemical bio‐markers, such CD34, CD117, CD28, Vimentin...
Ononin is a bioactive isoflavone of legumes. To explore the "effective forms" ononin, its metabolites were characterized using HPLC–ESI-IT-TOF-MSn after oral administration to rats. Metabolites (106), including 94 new metabolites, characterized, which contained 17 phase I, 23 hydroxylated and methylated, 54 sulfated, 10 glucuronidated, 2 sulfated glucuronidated metabolites. Six formononetin (aglycone ononin) simultaneously detected for first time. Twenty-three methylated number hydroxylation...
The early diagnosis of Parkinson's disease (PD) has always been a difficult problem to be solved clinically. At present, there is no clinical auxiliary diagnostic index for reference. We attempted extract potential biomarkers PD from the currently used scalp EEG detection methods in practice. calculated phase synchronization quantify synchrony channels various frequency bands (delta, theta, alpha and beta bands) PD. results showed that delta band was significantly lower than healthy level,...
The pathogenesis of ulcerative colitis (UC) is complex, and recent therapeutic advances remain unable to fully alleviate the condition.
Repairing articular cartilage damage is challenging due to its low regenerative capacity. In vitro, regeneration a potential strategy for the functional reconstruction of defects. A hydrogel an advanced material mimicking extracellular matrix (ECM) hydrophilicity and biocompatibility, which known as ideal scaffold regeneration. However, chondrocyte culture in vitro tends dedifferentiate, leading fibrosis reduced mechanical properties newly formed tissue. Therefore, it necessary understand...
In this study, we aimed to combine transcriptomic and network pharmacology explore the crucial mRNAs specific regulatory molecules of Buyang Huanwu Decoction (BYHWD) in intracerebral hemorrhage (ICH) treatment.C57BL/6 mice were randomly divided into three groups: sham, ICH, BYHWD. BYHWD (43.29 g/kg) was administered once a day for 7 days. An equal volume double-distilled water used as control. Behavioural histopathological experiments conducted confirm neuroprotective effects Brain tissues...