A5003720207- Natural Compounds in Disease Treatment
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory mediators and NSAID effects
- Essential Oils and Antimicrobial Activity
- Nigella sativa pharmacological applications
- Medicinal Plants and Bioactive Compounds
- Inflammasome and immune disorders
- Andrographolide Research and Applications
- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- IL-33, ST2, and ILC Pathways
- Psoriasis: Treatment and Pathogenesis
- Chemokine receptors and signaling
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Nephrotoxicity and Medicinal Plants
- Barrier Structure and Function Studies
- Saffron Plant Research Studies
State Key Laboratory of Food Science and Technology
2021-2024
Nanchang University
2021-2024
Malmö University
2003
The study aimed to explore the effects of Ganoderma atrum polysaccharide (PSG) on diabetic cardiomyopathy in type 2 rats. Results suggested that PSG significantly attenuated cardiomyopathy, as evidenced by alleviating heart histopathological changes and LDH release, mitigating weight loss, improving fasting blood glucose serum insulin levels. could also reduce ROS generation malondialdehyde contents, while enhancing antioxidant enzyme activities Nrf2 expression. Furthermore, reduced...
Macrophages could be polarized into two major sub-populations including classically activated (M1) and alternatively (M2) macrophages. The present study aimed to investigate the effects of Ganoderma atrum polysaccharide (PSG-1) on regulation macrophage polarization further explored associated molecular mechanisms. In this work, a lipopolysaccharide (LPS) plus IFN-γ IL-4 were used establish an in vitro model extreme states, namely pro-inflammatory M1 anti-inflammatory M2. results showed that...
Statins are mainly used to control hypercholesterolemia; however, recent studies have also ascribed anti‐inflammatory effects the statins. LFA703 is a novel statin‐derived compound, which potently inhibits lymphocyte function antigen‐1 (LFA‐1, CD11a/CD18) but does not affect HMG‐CoA reductase activity. The objective of this study was examine mechanisms in ischemia/reperfusion (I/R)‐induced leukocyte–endothelium interactions colon. For purpose, superior mesenteric artery occluded for 30 min...
This study aimed to investigate the protective effects of Houttuynia cordata polysaccharide (HCP) against chronic intestinal inflammation in rats that were subjected low-dose lipopolysaccharide once weekly for 6 weeks. Here, administration HCP significantly restored morphological changes intestine along with enhancement antioxidant enzymes including superoxide dismutase, catalase, and glutathione peroxidase activities, reduction malondialdehyde contents. treatment was also found attenuate...
This work aimed to investigate whether Chimonanthus nitens Oliv. essential oil (CEO)-mediated lung protection was implicated in gut-lung crosstalk. Results showed that CEO attenuated and intestinal impairment by improving histopathological changes inhibiting TLR4/NF-κB signaling pathway LPS-stimulated rats, suggesting there might be a mechanism for its involved interaction through manipulating the overlap pathological via similar inflammatory response. Furthermore, CEO-triggered parallel...