A5103392149- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Ubiquitin and proteasome pathways
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Histone Deacetylase Inhibitors Research
- Research on Leishmaniasis Studies
- Immune Cell Function and Interaction
- Ocular Diseases and Behçet’s Syndrome
- Sepsis Diagnosis and Treatment
- Biopolymer Synthesis and Applications
- Drug-Induced Hepatotoxicity and Protection
- Fetal and Pediatric Neurological Disorders
- Respiratory viral infections research
- IL-33, ST2, and ILC Pathways
- RNA Research and Splicing
- Hematopoietic Stem Cell Transplantation
- Analytical Chemistry and Chromatography
- Cell Adhesion Molecules Research
- Blood Coagulation and Thrombosis Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
Chongqing Cancer Hospital
2017-2025
Chongqing University
2019-2025
Zhongnan Hospital of Wuhan University
2025
Wuhan University
2025
Shanghai Jiao Tong University
2024
University of Michigan–Ann Arbor
2018-2024
The First Affiliated Hospital, Sun Yat-sen University
2021
Sun Yat-sen University
2021
82th Hospital of Pla
2020
Union Hospital
2017
The protein-protein interaction between menin and mixed lineage leukemia 1 (MLL1) plays a critical role in acute leukemias with translocations of the MLL1 gene or mutations nucleophosmin (NPM1) gene. As step toward clinical translation menin-MLL1 inhibitors, we report development MI-3454, highly potent orally bioavailable inhibitor interaction. MI-3454 profoundly inhibited proliferation induced differentiation cells primary patient samples NPM1 mutations. When applied as single agent,...
The protein-protein interaction between menin and mixed-lineage leukemia 1 (MLL1) plays an important role in development of acute with translocations the MLL1 gene solid tumors. Here, we report a new generation menin-MLL1 inhibitors identified by structure-based optimization thienopyrimidine class compounds. This work resulted compound 28 (MI-1481), which showed very potent inhibition (IC50 = 3.6 nM), representing most reversible inhibitor reported to date. crystal structure menin-28 complex...
Noise-induced hearing loss (NIHL) is among the most poorly treated diseases due to irreversible damage hair cells. Reactive oxygen species contribute NIHL pathogenesis by injuring inner ear Teriparatide (PTH1-34) exerts antioxidant properties in context of osteoporosis. Thus, current study, a multifunctional thermosensitive nanodelivery system developed, based on unique anatomical structure ear, load and sustain release PTH1-34 alleviate cell damage. LR27-a fusion peptide-is assembled from...
COVID-19 patients with severe symptoms still lack antiviral treatment options. Although remdesivir is the only FDA-approved drug for those patients, its efficacy limited by premature hydrolysis to nucleoside (NUC), low accumulation in disease-targeted tissue (lungs), and potency. In this study, we synthesized a new series of analogues modifying ProTide moiety. comparison remdesivir, lead compound MMT5-14 showed 2- 7-fold higher activity four variants SARS-CoV-2. By reducing hamsters,...
The continuous activation of macrophages play a critical role in the pathogenesis cytokine storm (CS). Considering that CS results from participation multiple cytokines, therapeutic effect single or its receptor-targeted blockade therapy remains uncertain. Melittin, which can systematically suppress overexpression proinflammatory mediators via inhibiting mitogen-activated protein kinase and nuclear factor kappa-B pathways activated macrophages, shows great potential alleviating acute...
Hematopoietic cell transplantation (HCT) is a proven and potentially curable therapy for hematological malignancies inherited disease. The main risk of HCT the development graft versus host disease (GVHD) acquired in up to 50% patients. Upregulation soluble ST2 (sST2) key clinical biomarker GVHD prognosis was shown be potential therapeutic target GVHD. Agents targeting sST2 reduce level after have mitigate progression. Here, we report 32 (or XY52) as lead inhibitor from our optimization...
Single-nucleotide polymorphisms (SNPs) near the interleukin (IL)28B gene have been shown to be associated with spontaneous clearance of hepatitis C virus (HCV) infection in western populations. Anti-HCV-reactive and HCV RNA-negative samples were often found Chinese blood donors. This study was determine whether IL28B variant is also natural outcome donors.A total 111 anti-HCV-negative donors 100 anti-HCV-reactive subjects enrolled this study. HCV-infected classified into group chronic...
The precise pathogenesis of anophthalmia/microphthalmia remains unknown. Prenatal observation the optic chiasm in fetuses with this malformation would assist understanding embryonic development condition. present study aimed to establish normal fetal size ranges decussation chiasm, nerves, and tracts axial plane using two-dimensional transabdominal ultrasound throughout gestation compare these corresponding values anophthalmia/microphthalmia.In total, 310 16 were included study. widths at...
Abstract Stimulator of interferon genes (STING) plays a pivotal role in regulating immune microenvironment for cancer immunotherapy. However, the use most STING agonists has been hindered by necessity intra-tumoral or intravenous administration, underscoring challenge developing an orally bioavailable agonist with favorable pharmacokinetic (PK) properties. In this study, we discovered oral featuring novel tricyclic benzo[4,5]thieno[2,3-c]pyrrole-1,3-dione scaffold, thus achieving both...
Abstract Background: Stimulator of interferon genes (STING), a dimeric transmembrane adapter protein, plays pivotal role in regulating tumor immune microenvironment and has been explored as therapeutic strategy against tumors. Most STING agonists were tested clinical trials using intratumoral injection with limited systemic efficacy. Several systemically administered have progressed to trials, their efficacy yet be determined, while toxicity may limit application. Our study aimed develop...
To retrospectively analyze the effect of hyperthermic intraperitoneal chemotherapy (HIPEC) on progression free survival (PFS) advanced gastric cancer (GC) and colorectal (CRC).
To explore the value of HLA-DRB1 gene in predicting outcome unexplained recurrent spontaneous abortion (URSA) treated with paternal lymphocyte alloimmunization therapy (PLAT) Henan Hans.Three hundred URSA patients were recruited. Following PLAT treatment, they divided into two groups according to pregnancy. Polymerase chain reaction sequence specific primer (PCR-SSP) conducted analyze gene.For those who have received frequency HLA-DRB1*11 was significantly lower successfully cases than...
目的 探讨弥漫大B细胞淋巴瘤（DLBCL）合并血栓性血小板减少性紫癜（TTP）的临床表现与诊治要点。 方法 回顾分析联勤保障部队第九四○医院新诊断的1例DLBCL并发TTP患者的诊治过程，并进行文献复习。 结果 该患者首先确诊DLBCL，治疗缓解4年后血小板减少突然加剧，ADAMTS13活性严重缺乏，DLBCL合并TTP诊断成立，确诊后行输注新鲜冰冻血浆及激素治疗，治疗后病情明显好转。 结论 DLBCL并发TTP较为少见，可能是ADAMTS13活性严重缺乏导致血小板微血栓形成，一经确诊后进行血浆置换或输注冰冻血浆，可取得较好疗效。