A5082987446- Bone health and treatments
- Bone Tissue Engineering Materials
- Bone Metabolism and Diseases
- Chemical Synthesis and Analysis
- Supramolecular Self-Assembly in Materials
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Protein Hydrolysis and Bioactive Peptides
- Antimicrobial Peptides and Activities
- Bone and Dental Protein Studies
- Bone health and osteoporosis research
- 3D Printing in Biomedical Research
- Salivary Gland Disorders and Functions
- Osteoarthritis Treatment and Mechanisms
- Bone and Joint Diseases
- Polydiacetylene-based materials and applications
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- COVID-19 Impact on Reproduction
- Medical and Biological Sciences
- Hearing, Cochlea, Tinnitus, Genetics
- Cellular Mechanics and Interactions
- Dental Implant Techniques and Outcomes
- Dendrimers and Hyperbranched Polymers
- COVID-19 and Mental Health
Zhongnan Hospital of Wuhan University
2019-2025
Wuhan University
2019-2025
Osteoporosis is a systemic skeletal disease caused by an imbalance between bone resorption and formation. Current treatments primarily involve medication hormone therapy. However, these lack directionality are often ineffective for locally severe osteoporosis, with the potential complex adverse reactions. Consequently, treatment strategies using bioactive materials or external interventions have emerged as most promising approaches. This review proposes twelve microenvironmental targets...
Previous parathyroid hormone (PTH)-related peptides (PTHrPs) cannot be used to prevent implant loosening in osteoporosis patients due the catabolic effect of local sustained release. A novel PTHrP (PTHrP-2) that can locally promote osseointegration macroporous titanium alloy scaffold (mTAS) and counteract slippage is designed. In vitro, PTHrP-2 enhances proliferation, adhesion, osteogenic differentiation bone marrow-derived mesenchymal stem cells (BMSCs) within mTAS. Further, it promotes...
Noise-induced hearing loss (NIHL) is among the most poorly treated diseases due to irreversible damage hair cells. Reactive oxygen species contribute NIHL pathogenesis by injuring inner ear Teriparatide (PTH1-34) exerts antioxidant properties in context of osteoporosis. Thus, current study, a multifunctional thermosensitive nanodelivery system developed, based on unique anatomical structure ear, load and sustain release PTH1-34 alleviate cell damage. LR27-a fusion peptide-is assembled from...
Bone defects are one of the toughest challenges faced by orthopedic surgeons worldwide, especially at critical sizes, which caused severe trauma, malignancy, or congenital disease. The ideal bone tissue-engineered scaffold for regeneration is that has good osteoconductivity, osteoinductivity, pore structure, and antibacterial properties. Metal ions have been recognized in recent years to be essential regulators metabolism, they widely used tissue engineering. In particular, zinc interest...
Surgery combined with systemic chemotherapy is currently the main modality of cancer treatment. However, development multidrug resistance and inevitable surgical residual lesions lead to high rates recurrence mortality. Meanwhile, drug toxic side effects bleeding complications seriously reduce quality life patients. To avoid comprehensively optimize treatment, this work provides a novel injectable cell penetrating peptide octa-arginine (R8)-modified RADA16 (RR) self-assembling nanofiber...
Supramolecular peptide nanofiber hydrogels are emerging biomaterials for tissue engineering, but it is difficult to fabricate multi-functional systems by simply mixing several short-motif-modified supramolecular peptides because relatively abundant motifs generally hinder cross-linking or the formation of long nanofiber. Coupling bioactive factors assembling backbone an ideal strategy design in spite challenging synthesis and purification. Herein, a peptide, P1R16, developed coupling factor,...
Primary liver carcinoma is one of the most common malignant tumors with a poor prognosis. This study aims to uncover potential mechanisms and identify core biomarkers hepatocellular (HCC). The HCC gene expression profile GSE49515 was chosen analyze differentially expressed genes from purified RNA peripheral blood mononuclear cells, including 10 patients normal individuals. GO KEGG pathway analysis PPI network were used, enrichment out 15 hub evaluated using GEPIA GSEA, respectively. We...