A5034148530- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Ferroptosis and cancer prognosis
- Intraoperative Neuromonitoring and Anesthetic Effects
- RNA modifications and cancer
- Ophthalmology and Eye Disorders
- Cell death mechanisms and regulation
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Retinal Development and Disorders
- Mitochondrial Function and Pathology
- Pharmacogenetics and Drug Metabolism
- Organ Transplantation Techniques and Outcomes
- Diet and metabolism studies
- Intraocular Surgery and Lenses
- Cancer-related molecular mechanisms research
- Retinal and Macular Surgery
Wuhan University
2019-2025
Renmin Hospital of Wuhan University
2021-2025
Zhongnan Hospital of Wuhan University
2019
This study investigates the impact of choroidal blood flow on pigment epithelial detachment (PED) and subretinal fluid (SRF) in central serous chorioretinopathy (CSC). We categorized CSC patients into groups with without PED, alongside healthy controls. Using SS-OCT, we measured three-dimensional vascular index (CVI), volume (CVV), SRF PED area volume, subfoveal thickness (SFCT), choroid beneath highest point (PED-ct). Image-J was utilized to analyze void (FVa) percentage (FV%)...
To compare the choroidal vascularity of large- and middle-sized vessels choriocapillaris (CC) perfusion in patients with different degrees myopia using swept-source optical coherence tomography angiography (SS-OCTA).One hundred thirteen people were enrolled. SS-OCTA was performed to analyze CC perfusion. Three-dimensional (3D) index (CVI) luminal volumes (LV) obtained by artificial intelligence segmentation lumen Volume OCT images. assessed flow signal voids (FSVs).In macular, multiple...
To design and evaluate a deep learning model based on ultra-widefield images (UWFIs) that can detect several common fundus diseases. Based 4574 UWFIs, was trained validated identify normal eight diseases, namely referable diabetic retinopathy, retinal vein occlusion, pathologic myopia, detachment, retinitis pigmentosa, age-related macular degeneration, vitreous opacity, optic neuropathy. The tested three test sets with data volumes of 465, 979, 525. performance the networks, EfficientNet-B7,...
Macrophage-like cells (MLCs) located at the ILM were observed in live human retinas using adaptive optics optical coherence tomography (OCT) as well clinically-used OCT. The study aimed to quantitatively analyzing MLCs vitreoretinal interface (VRI) diabetic retinopathy (DR) en face OCT and swept-source angiography (SS-OCTA).190 DR eyes included study, with 70 proliferative (PDR) 120 non- (NPDR) eyes. Sixty-three from normal subjects controls. visualized a 5 μm slab above VRI centered on...
Inaccurate, untimely diagnoses of fundus diseases leads to vision-threatening complications and even blindness. We built a deep learning platform (DLP) for automatic detection 30 using ultra-widefield fluorescein angiography (UWFFA) with experts aggregation. This retrospective cross-sectional database study included total 61,609 UWFFA images dating from 2016 2021, involving more than 3364 subjects in multiple centers across China. All were divided into different groups. The state-of-the-art...
To determine the relationship between large-sized and medium-sized choroidal vessels choriocapillaris using three-dimensional vascularity index (3D CVI) percentage of flow deficits (FD%).Prospective observational study. The main outcome measures included volume parameters CVI, mean thickness, total volume, luminal stromal volume), (FD%, average area FD, FD count), age axial length.A 63 healthy individuals with an 40.60 ± 12.32 years were in this Univariate analysis showed that FD% (R =...
To investigate the distribution of macrophage-like cells (MLCs) across different stages posterior vitreous detachment (PVD).
Objectives: to quantitatively analyze macrophage-like cells (MLCs) at the vitreoretinal interface in retinal vein occlusion (RVO) using swept-source optical coherence tomography angiography (SS-OCTA) and en face (OCT). Methods: The study included 72 RVO patients, with 43 acute patients 29 chronic patients. For a normal control, 64 fellow eyes were included. MLCs visualized 5 μm OCT slab above centered on fovea. After semi-automatic binarization quantification, we evaluated MLC count density...
Purpose: To explore the relationships of region-specific properties ultra-widefield fluorescence angiography (UWFFA) images with two adverse outcomes, diabetic macular edema (DME) and proliferative retinopathy (PDR), also severity (DR). Methods: A cross-sectional observational study was performed to retrospectively analyze UWFFA patients DR. All underwent optical coherence tomography examination. Leakage index microaneurysm (MA) count were measured using Trainable Weka Segmentation, a...
Primary liver carcinoma is one of the most common malignant tumors with a poor prognosis. This study aims to uncover potential mechanisms and identify core biomarkers hepatocellular (HCC). The HCC gene expression profile GSE49515 was chosen analyze differentially expressed genes from purified RNA peripheral blood mononuclear cells, including 10 patients normal individuals. GO KEGG pathway analysis PPI network were used, enrichment out 15 hub evaluated using GEPIA GSEA, respectively. We...
Purpose: To compare peripapillary choroidal vascularity among Leber's Hereditary Optic Neuropathy (LHON) patients at different stages of natural course and healthy controls using optical coherence tomography (OCT), to evaluate changes in LHON before after gene therapy. Methods: 57 15 were enrolled this prospective clinical study. divided into three duration groups based on stage disease progression. Both underwent OCT scans focused the optic disc baseline with Heidelberg Spectralis, 1, 3, 6...
To describe the characteristics of peripapillary hyperreflective ovoid mass-like structure (PHOMS) in myopic children and to investigate factors associated with PHOMS.
<title>Abstract</title> Purpose Investigate how choroidal blood flow affacts pigment epithelial detachment (PED) and subretinal fluid (SRF) in central serous chorioretinopathy (CSC) . Methods We collected CSC patients, dividing into group with PED without PED, as well healthy individuals. Using SS-OCT to measure three-dimensional vascular index (CVI), volume (CVV), SRF area volume, subfoveal thickness (SFCT), the choroid beneath highest point of PED(PED-ct). Image-J was used analyze...
Abstract Objectives: To quantitatively analyze macrophage-like cells (MLCs) at the vitreoretinal interface in retinal vein occlusion (RVO) using swept-source optical coherence tomography angiography (SS-OCTA). Methods: The study included 72 RVO patients, with 43 acute patients and 29 chronic patients. For a normal control, 64 fellow eyes were included. MLCs visualized 5μm en face OCT slab above centered on fovea. After semi-automatic binarization quantification, we evaluated MLC count...
AIM: To quantify the area and density of retinal vascularity by ultra-widefield fluorescein angiography (UWFA). METHODS: In a retrospective study, UWFA images were obtained using an imaging device in 42 normal eyes patients. Central peripheral steered used to define edge vasculature certified grader. The length from center optic disc (RVL) each quadrant total vascular perfusion (RVPA) determined grader OptosAdvance software. (RVD) was quantified different zones central-steered Image J...
Purpose: To explore the relationship between retinal hemorrhage in green and red channels on ultra-widefield fundus images (UWFIs) nonperfusion area (NPA) fluorescein angiography patients with acute branch vein occlusion (BRVO). Methods: This was a retrospective cross-sectional study 96 patients, including 46 ischemic BRVO 50 nonischemic BRVO. Correlation analysis channel (GCH), (RCH), NPA performed. Panretina divided into posterior peripheral areas. Results: Ischemic showed significantly...
Liver ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver transplantation, and other surgeries. It’s important to study the targets towards IRI for preventing mitigating clinical renal injury. It has been reported that peroxisome proliferator activated receptor gamma (PPARγ) protects against by targeting family with sequence similarity 3 member A (FAM3A). At meantime, noncoding RNAs, including lncRNAs miRNAs, have also play roles on process hepatic IRI. This...