A5102008205- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- RNA modifications and cancer
- Peroxisome Proliferator-Activated Receptors
- Acute Ischemic Stroke Management
- Epigenetics and DNA Methylation
- Traumatic Brain Injury and Neurovascular Disturbances
- Nitric Oxide and Endothelin Effects
- Cancer, Hypoxia, and Metabolism
- Methane Hydrates and Related Phenomena
- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Protist diversity and phylogeny
- Microbial Community Ecology and Physiology
- Eicosanoids and Hypertension Pharmacology
- Cholesterol and Lipid Metabolism
- Ovarian cancer diagnosis and treatment
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Phytase and its Applications
- AI in cancer detection
Nankai University
2022-2025
Beijing Tian Tan Hospital
2024-2025
Capital Medical University
2024-2025
Tianjin First Center Hospital
2025
Tianjin Medical University
2025
Renmin Hospital of Wuhan University
2022-2024
China Agricultural University
2021-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Northwestern Polytechnical University
2022-2024
Summary Melatonin, a natural phytohormone in plants, plays multiple critical roles plant growth and stress responses. Although melatonin biosynthesis‐related genes have been suggested to possess diverse biological functions, their functional mechanisms regulating rice grain yield remain largely unexplored. Here, we uncovered the of caffeic acid O ‐methyltransferase ( OsCOMT ) gene mediating through dual regulation leaf senescence vascular development. In vitro vivo evidence revealed that is...
The exploration of drugs derived from natural sources holds significant promise in addressing current limitations ovarian cancer (OC) treatments. While previous studies have highlighted the remarkable anti-cancer properties compound β-sitosterol (SIT) across various tumors, its specific role OC treatment remains unexplored. This study aims to investigate anti-tumor activity SIT using vitro and vivo models, delineate potential mechanisms, establish a preclinical theoretical foundation for...
Endometrial cancer (EC) is a prevalent gynecological malignancy, and metabolic disorders are among its most significant risk factors.Abnormal iron metabolism associated with the progression of malignancy.Nevertheless, involvement in EC remains uncertain.Ceruloplasmin (CP) functions as multicopper oxidase ferroxidase, playing crucial role maintaining balance between copper iron.Prior research has demonstrated that dysregulated expression CP important clinical implications EC.However, specific...
Peroxisome proliferator–activated receptor γ (PPARγ) is a member of the nuclear superfamily and polarizes macrophages into an anti-inflammatory M2 state. Integrins are transmembrane receptors that drive various cellular functions, including monocyte adhesion foam cell formation. In this study, we first reported expression integrins αV β5 was up-regulated by PPARγ activation in RAW264.7 cells human peripheral blood monocytes. Luciferase reporter ChIP assay revealed directly bound to potential...
Excessive activation of the NLRP3 inflammasome is implicated in cardiovascular diseases. Statins exert an anti-inflammatory effect independent their cholesterol-lowering effect. This study investigated potential role statins endothelial cells (ECs). Western blotting and quantitative reverse-transcription polymerase chain reaction showed that oxidized low-density lipoprotein (ox-LDL) or tumor necrosis factor α (TNF<i>α</i>) activated ECs. Simvastatin mevastatin significantly suppressed...
Tumor mutational burden (TMB) has been reported to determine the response immunotherapy, thus affecting patient's prognosis in many cancers. However, it is unclear whether TMB or TMB-related signature could be used as prognostic indicators for ovarian cancer (OC), its potential association with immune infiltration remains poorly understood. Therefore, this study aimed develop a novel risk model (TMBrisk) predict of OC patients on basis exploring genes, and explore between TMB/TMBrisk...
Ovarian cancer (OC) is one of the major diseases threatening women's health and life. Estimating burden trends risk factors OC can help develop effective management prevention measures. However, there a lack comprehensive analysis concerning in China. In this study, we aimed to assess predict China from 1990 2030, make comparison with global level.We extracted prevalence, incidence, mortality, disability-adjusted life years (DALYs), lost (YLLs), lived disability (YLDs) data Global Burden...
As a hallmark for cancer, aerobic glycolysis, also known as the Warburg effect contributes to tumor progression. However, roles of glycolysis on cervical cancer remain elusive. In this work, we identified transcription factor HOXA1 novel regulator glycolysis. High expression is closely associated with poor outcome patients. And, altered enhance or reduce and progression in cancer. Mechanistically, directly regulates transcriptional activity ENO1 PGK1, thus induce promote Moreover,...
Abstract DExD/H-box helicases are crucial regulators of RNA metabolism and antiviral innate immune responses; however, their role in bacteria-induced inflammation remains unclear. Here, we report that DDX5 interacts with METTL3 METTL14 to form an m6A writing complex, which adds N6-methyladenosine transcripts toll-like receptor (TLR) 2 TLR4, promoting decay via YTHDF2-mediated degradation, resulting reduced expression TLR2/4. Upon bacterial infection, is recruited Hrd1 at the endoplasmic...
Zoonotic poxviruses such as mpox virus (MPXV) continue to threaten public health safety since the eradication of smallpox. Vaccinia (VACV), prototypic poxvirus used vaccine strain for smallpox eradication, is best-characterized member family. VACV encodes a serine protease inhibitor 1 (SPI-1) conserved in all orthopoxviruses, which has been recognized host range factor modified Ankara (MVA), an approved and promising vector. FAM111A (family with sequence similarity 111 A), nuclear protein...
Introduction Bioactive peptides based on foodstuffs are of particular interest as carriers for calcium delivery due to their safety and high activity. The phosphorylated peptide has been shown enhance absorption bone formation. Method A novel complex phosphorylation modification derived from soybean protein was introduced, the mechanism, stability, osteogenic differentiation bioactivity with or without were studied. Result calcium-binding capacity soy (SPP) reached 50.24 ± 0.20 mg/g. result...
Introduction Preclinical studies have shown that oxygen therapy can improve ischaemic brain tissue tension, reduce reperfusion injury after revascularisation, promote neuroregeneration and inhibit inflammatory responses potentially exerting a beneficial effect endovascular treatment (EVT) in patients with acute stroke (AIS). However, the optimal fraction of inspired (FiO 2 ) during EVT under general anaesthesia is currently unknown. Therefore, we are conducting randomised controlled trial...
ABSTRACT Background Our study aimed to explore the specific functions and potential mechanisms of miR‐224‐5p in non‐small cell lung cancer (NSCLC). Methods We first analyzed expression NSCLC patients lines through GEO database qRT‐PCR analysis. Then, we used MTT assays, wound healing Transwell western blotting evaluate effects on proliferation, migration, invasion, epithelial–mesenchymal transition (EMT). Furthermore, a xenograft tumor model effect growth. Potential binding targets were...
Hyperglycemia-induced endothelial endoplasmic reticulum (ER) stress is implicated in the pathophysiology of diabetes and its vascular complications. Procyanidins are enriched many plant foods have been demonstrated to exert several beneficial effects on diabetes, cardiovascular other metabolic diseases. In present study, we investigated effect procyanidin B2 (PCB2), most widely distributed natural procyanidin, ER evoked by high glucose cells (ECs) underlying mechanisms. We showed that PCB2...