A5103102863- interferon and immune responses
- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- Viral Infections and Vectors
- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Hormonal and reproductive studies
- Sexual function and dysfunction studies
- Prostate Cancer Treatment and Research
- Viral Infectious Diseases and Gene Expression in Insects
- Mosquito-borne diseases and control
- Cancer Mechanisms and Therapy
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Entomopathogenic Microorganisms in Pest Control
- Urinary Bladder and Prostate Research
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Tuberculosis Research and Epidemiology
- Insect Resistance and Genetics
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- NF-κB Signaling Pathways
- Mycobacterium research and diagnosis
Qingdao University of Science and Technology
2022-2025
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
Biotechnology Research Institute
2019-2025
Chinese Academy of Agricultural Sciences
2014-2025
Sir Run Run Shaw Hospital
2023-2025
Zhejiang University
2023-2025
Institute of Animal Sciences
2015-2023
Huazhong University of Science and Technology
2018-2022
Tongji Hospital
2018-2022
Background Erectile dysfunction (ED) occurs more frequently and causes a worse response to the first-line therapies in diabetics compared with non-diabetic men. Corpus cavernosum vascular plays pivotal role occurrence of diabetes mellitus ED (DMED). The aim this study was investigate protective effects glucagon-like peptide-1 (GLP-1) analog liraglutide on explore underlying mechanisms vivo vitro. Methods Type 1 induced rats by streptozotocin, apomorphine test for screening DMED model...
African swine fever (ASF) is a devastating infectious disease caused by virus (ASFV). The ASFV genome encodes multiple structural and non-structural proteins that contribute to evasion of host immunity. In this study, we determined the viral protein MGF360-14L inhibits interferon-β (IFN-β) promoter activity induced cGAS-STING signaling. was also found downregulate expression IRF3 promote its degradation through ubiquitin-meditated proteolysis. Moreover, shown interact with destabilize...
Burn injuries are one of the most devastating traumas. The development polymer-based hydrogel dressings to prevent bacterial infection and accelerate burn wound healing is continuously desired. Mechanical strong hydrogels that encapsulated antibacterial drugs have gained increasing attention. Herein, aramid nanofibers (ANFs)-reinforced rhein fibrous (ANFs/Rhein) were fabricated through a one-pot procedure serve as possible treatment for Staphylococcus aureus-infected wound. ANFs preserved...
Androgen receptor (AR) is the principal molecule in prostate cancer (PCa) etiology and therapy. AR re‐activation still remains a major challenge during treatment of castration‐resistant (CRPC) tumors that relapse after castration therapies. Recent reports have indicated enrichment Ser81‐phosphorylated (pS81) nucleus CRPC cells, CDK1 CDK9 as kinases phosphorylating at S81. In current study we showed pS81 preferentially localized both rapid biopsy metastatic samples PCa xenografts, nuclear...
Cyclic GMP-AMP synthase (cGAS) is a major DNA sensor. The recognition of cytosolic by cGAS triggers robust innate immune response that restricts the replication diverse viral pathogens through type I interferon (IFN) and nuclear factor-κB (NF-κB) pathways. African swine fever virus (ASFV) large complex reported to strongly inhibit cGAS-STING signaling pathway. Herein, 12 ASFV structural proteins were screened determine their effects on Ectopic expression caspid protein M1249L significantly...
Excessive acetaminophen (APAP) induces excess reactive oxygen species (ROS), leading to liver damage. Pterostilbene (PTE) has excellent antioxidant and anti-inflammatory activities, but poor solubility limits its biological activity. In this study, we prepared PTE-loaded Soluplus/poloxamer 188 mixed micelles (PTE-MMs), the protective mechanism against APAP-induced injury was investigated. vitro results showed that PTE-MMs protected H2O2-induced HepG2 cell proliferation inhibition, ROS...
Zoonotic poxviruses such as mpox virus (MPXV) continue to threaten public health safety since the eradication of smallpox. Vaccinia (VACV), prototypic poxvirus used vaccine strain for smallpox eradication, is best-characterized member family. VACV encodes a serine protease inhibitor 1 (SPI-1) conserved in all orthopoxviruses, which has been recognized host range factor modified Ankara (MVA), an approved and promising vector. FAM111A (family with sequence similarity 111 A), nuclear protein...
Introduction: Cystic echinococcosis (CE), a chronic disabling parasitic zoonosis, poses great threat to public health and livestock production causes huge economic losses globally. The commercial Quil-A-adjuvanted Eg95 vaccine was empirically effective for CE control; however, it is expensive has side effects insufficient immunity. Purpose: This study aimed employ novel adjuvant consisting of delivery system an immune potentiator assess its adjuvanticity antigen, thereby developing safe...
Acute kidney injury (AKI) is the most common side effect of anti-cancer drug cisplatin, and currently, no effective preventive measures are available in clinical practice. Oxidative stress DNA damage mechanisms may be involved cisplatin-induced AKI. In this study, we prepared Kolliphor HS15-based myricetin-loaded (HS15-Myr) nanomicelles explored mechanism protection against vitro results showed that HS15-Myr enhanced antioxidant activity myricetin (Myr) inhibited proliferation inhibition...
Diabetes mellitus (DM) induces impairment of male reproductive system and is considered as a key factor that could partially provide an explanation for infertility. Thus, understanding the mechanism underlying DM-induced infertility will aid in identification novel therapeutic stratagems.To delineate role ROS/JAK2/NFκB pathway low function impaired spermatogenesis. Additionally, to investigate protective effect monomeric Berberine (BB) inhibits pathway, pathogenesis infertility.12-week-old...
Fifty-five samples (15.62%) collected from dogs and cats were identified as canine parvovirus (CPV) infection in Beijing during 2010–2013. The nucleotide identities aa similarities 98.2–100% 97.7–100%, respectively, when compared with the reference isolates. Also, several synonymous non-synonymous mutations also recorded for first time. New CPV-2a was dominant, accounting 90.90% of samples. Two 16 new (12.5%), showing 100% those dogs. Twelve (15.78%) completely immunized found to be CPV-2a,...