A5020417557- Seaweed-derived Bioactive Compounds
- Protein Tyrosine Phosphatases
- Marine Sponges and Natural Products
- Galectins and Cancer Biology
- Fluorine in Organic Chemistry
- Catalytic C–H Functionalization Methods
- Bioactive Compounds and Antitumor Agents
- Microbial Natural Products and Biosynthesis
- Sulfur-Based Synthesis Techniques
- Carbohydrate Chemistry and Synthesis
- Synthesis and biological activity
- Radical Photochemical Reactions
- Cancer, Hypoxia, and Metabolism
- Molecular Junctions and Nanostructures
- Inorganic Fluorides and Related Compounds
- Cancer Mechanisms and Therapy
- Surface and Thin Film Phenomena
- Synthesis of Organic Compounds
- Steroid Chemistry and Biochemistry
- PARP inhibition in cancer therapy
- Echinoderm biology and ecology
- Algal biology and biofuel production
- Traditional Chinese Medicine Studies
- Click Chemistry and Applications
- Macrophage Migration Inhibitory Factor
Qingdao National Laboratory for Marine Science and Technology
2016-2025
Shandong University
2019-2025
Qingdao Binhai University
2019-2025
Marine Biology Institute of Shandong Province
2025
State Key Laboratory of Microbial Technology
2019-2024
Qingdao Center of Resource Chemistry and New Materials
2021
Institute of Marine Biotechnology
2021
Institute of Oceanology
2009-2020
Chinese Academy of Sciences
2010-2020
University of Chinese Academy of Sciences
2009-2020
Abstract Phenolic compounds are industrially versatile chemicals, also the most ubiquitous pollutants. Recently, biosynthesis and biodegradation of phenols has attracted increasing attention, while phenols’ toxicity is a major issue. Here, we evolved phloroglucinol-tolerant Escherichia coli strains via adaptive evolution, three mutations (Δ sodB , Δ clpX fetAB overexpression) prove great assistance in tolerance improvement. We discover that phloroglucinol complexes with iron promotes...
Natural products offered more opportunities to develop new drugs and leading compounds as potent PTP1B inhibitors for treating T2DM.
Poly(ADP-ribose) polymerase-1 (PARP-1) is a new potential target for anticancer drug discovery. A series of bromophenol–thiosemicarbazone hybrids as PARP-1 inhibitors were designed, synthesized, and evaluated their antitumor activities. Among them, the most promising compound, 11, showed excellent selective inhibitory activity (IC50 = 29.5 nM) over PARP-2 > 1000 potent activities toward SK-OV-3, Bel-7402 HepG2 cancer cell lines 2.39, 5.45, 4.60 μM), along with inhibition tumor growth in an...
Pancreatic cancer is a highly malignant and lacks effective therapeutic targets. Protein-tyrosine phosphatase 1B (PTP1B), validated target for diabetes obesity, also plays critical positive or negative role in tumorigenesis. However, the of PTP1B pancreatic remains elusive. Here, we initially demonstrated that was expressed tumors, positively correlated with distant metastasis tumor staging, indicated poor survival. Then, inhibition either by shRNA specific small-molecule inhibitor...
Bromophenol is a type of natural marine product. It has excellent biological activities, especially anticancer activities. In our study searching for potent drugs, novel bromophenol derivative containing indolin-2-one moiety, 3-(4-(3-([1,4'-bipiperidin]-1'-yl)propoxy)-3-bromo-5-methoxybenzylidene)-N-(4-bromophenyl)-2-oxoindoline-5-sulfonamide (BOS-102) was synthesized, which showed activities on human lung cancer cell lines. A the mechanisms indicated that BOS-102 could significantly block...
Designing selective PARP-1 inhibitors has become a new strategy for anticancer drug development. By sequence comparison of and PARP-2, we identified possible site (S site) consisting several different amino acid residues α-5 helix D-loop. Targeting this S site, 140 compounds were designed, synthesized, characterized their activities mechanisms. Compound
A novel cobalt-catalyzed radical 1,3-diphosphination of alkenes was developed, which enables straightforward access to 1,3-diphosphine skeleton compounds under mild conditions.
The synthesis of medicinally interesting aryldifluoromethylated compounds has drawn significant research attention in recent years. Herein, we report an unprecedented iron-mediated process for the selective defluorination trifluoromethylarenes to achieve 1,2-difluoroalkylthiolation alkenes. Preliminary mechanistic studies revealed that thiolate anion, trifluoromethylarene, and iron cation could form electron donor-acceptor (EDA) complex, which induced then difunctionalization alkenes obtain...
Oseltamivir is a drug that has been widely used to prevent and treat influenza A B. In this work, an ultrasensitive, simple, novel electrochemiluminescence (ECL) sensor combined with molecularly imprinted polymers (MIP-ECL) based on graphene-like two-dimensional material, Mxene quantum dots (MQDs) was constructed selectively detect oseltamivir. polymer membrane containing oseltamivir template by electropolymerization elution of modified MQDs glassy carbon electrode. Under optimized...
An anaerobic 1,2-/1,3-hydroxytrifluoromethylation of unactivated alkenes is described. This reaction proceeds in mild and environmentally friendly conditions without photocatalyst metal catalyst, allowing access to a wide range β- γ-trifluoromethyl alcohols. Preliminary mechanistic investigations indicate that the accomplishment this protocol relies on dual functionality photoexcited triplet nitroarenes, which serve as oxygen atom source enable single-electron transfer (SET) process with CF
The formation of C–C and C–S bonds is fundamentally important for the production pharmaceuticals, biologically active molecules, organic natural products. Herein, we report an unprecedented iron-catalyzed process bond coupling to achieve 1,2-arylthiolation alkenes. This proceeds efficiently without use organometallic reagents features readily available starting materials, a broad substrate scope, simple reaction conditions
Structural evolution of pentacene thin films on Ag(110) crystal, during molecular deposition and a subsequent change substrate temperature, was investigated in situ by beam epitaxy low-energy electron diffraction technique. The molecules exhibit high mobility the surface at room temperature adsorbate shows structural from disorder submonolayer to an ordered structure when it reaches one monolayer. Heating $145\ifmmode^\circ\else\textdegree\fi{}\mathrm{C}$ results no further transition....
Glioblastoma stem cells (GSCs) are the initiating in glioblastoma multiforme (GBM) and contribute to resistance of GBM chemotherapy radiation. In present study, we investigated effects cardamonin (3,4,2,4-tetrahydroxychalcone) on self-renewal apoptosis GSCs, if its action is associated with signal transducer activator transcription 3 (STAT3) pathway. CD133(+) a kind GSCs line, was established from human tissues. Cardamonin inhibited proliferation induced CD133+ GSCs. The proapoptotic...
3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-(isopropoxymethyl)benzyl)benzene-1,2-diol (HPN) is a synthetic analogue of 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(ethoxymethyl)benzyl)benzene-1,2-diol (BPN), which isolated from marine red alga Rhodomela confervoides with potent protein tyrosine phosphatase 1B (PTP1B) inhibition (IC(50) = 0.84 μmol/L). The in vitro assay showed that HPN exhibited enhanced inhibitory activity against PTP1B IC(50) 0.63 μmol/L and high selectivity other PTPs (T cell...
Radical-mediated 1,2-difunctionalization of olefins is a well-established synthetic technique widely used in the rapid construction structurally diverse molecular entities. However, radical-mediated 1,3-difunctionalization reactions are rare, and substrates generally limited to strained skeletons. Here, we report practical approach for available β,γ-unsaturated ketones via radical cascade process including visible light-irradiated addition, thermodynamic stability-driven 1,2-carbonyl...