A5079382842- Protein Tyrosine Phosphatases
- Seaweed-derived Bioactive Compounds
- Galectins and Cancer Biology
- Bioactive Compounds and Antitumor Agents
- Marine Sponges and Natural Products
- Carbohydrate Chemistry and Synthesis
- Echinoderm biology and ecology
- Synthesis and biological activity
- Synthesis of Organic Compounds
- Sulfur Compounds in Biology
- Antioxidant Activity and Oxidative Stress
- Spectroscopy and Quantum Chemical Studies
- Cancer Mechanisms and Therapy
- Advanced biosensing and bioanalysis techniques
- Vanadium and Halogenation Chemistry
- Glycosylation and Glycoproteins Research
- Macrophage Migration Inhibitory Factor
- Microbial Natural Products and Biosynthesis
- Neuropeptides and Animal Physiology
- Photosynthetic Processes and Mechanisms
- Molecular Sensors and Ion Detection
- Peptidase Inhibition and Analysis
- Diabetes Treatment and Management
- Click Chemistry and Applications
- Vitamin K Research Studies
Chinese Academy of Sciences
2011-2022
Institute of Oceanology
2011-2022
Qingdao National Laboratory for Marine Science and Technology
2017-2021
University of Chinese Academy of Sciences
2011-2020
Institute of Botany
2006
Bromophenol is a type of natural marine product. It has excellent biological activities, especially anticancer activities. In our study searching for potent drugs, novel bromophenol derivative containing indolin-2-one moiety, 3-(4-(3-([1,4'-bipiperidin]-1'-yl)propoxy)-3-bromo-5-methoxybenzylidene)-N-(4-bromophenyl)-2-oxoindoline-5-sulfonamide (BOS-102) was synthesized, which showed activities on human lung cancer cell lines. A the mechanisms indicated that BOS-102 could significantly block...
3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-(isopropoxymethyl)benzyl)benzene-1,2-diol (HPN) is a synthetic analogue of 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(ethoxymethyl)benzyl)benzene-1,2-diol (BPN), which isolated from marine red alga Rhodomela confervoides with potent protein tyrosine phosphatase 1B (PTP1B) inhibition (IC(50) = 0.84 μmol/L). The in vitro assay showed that HPN exhibited enhanced inhibitory activity against PTP1B IC(50) 0.63 μmol/L and high selectivity other PTPs (T cell...
Abstract 3‐Bromo‐4,5‐ bis (2,3‐dibromo‐4,5‐dihydroxybenzyl)‐1,2‐benzenediol (BDB) is a bromophenol purified from the marine red alga Rhodomela confervoides and exhibits potent protein tyrosine phosphatase 1B (PTP1B) inhibition (IC 50 = 1.7 µmol/L). In an effort to improve PTP1B inhibitory activity, series of derivatives were designed, synthesized, evaluated in vitro . The preliminary structure–activity relationship indicated that tricyclic scaffold multi‐bromine atoms (four five) attached...
One new sesquiterpene, (4E)-1-bromo-5-[(1'S*,3'R*)-3'-bromo-2',2'-dimethyl-6'-methylenecyclohexyl]-3-methylpent-4-ene-2,3-diol (1), and fifteen known sesquiterpenes, isopalisol (2), luzonensol (3), palisadin B (4), aplysistatin (5), A (6), 4-hydroxyl-palisudin C (7), 5-acetoxypalisadin (8), 10-hydroxyaristolan-9-one (9), aristol-8-en-1-one (10), aristolan-9-en-1-one (11), aristolan-1(10)-en-9-one (12), aristolan-1(10)-en-9-ol (13), aristolan-1(10),8-diene (14), aristolan-1,9-diene (15)...
The close relationship between the consumption of sea cucumber and health status stems from nutritional functional substances found in that play a key role prevention different diseases. processing methods have great effect upon cucumber. A superior product should not only be abundant substances, but also require an easy cost effective method. This study compared influence on stability macronutrients micronutrients present order to recommend products could provide high quality. five...
A series of bromophenol hybrids with N-containing heterocyclic moieties were designed, and their anticancer activities against a panel five human cancer cell lines (A549, Bel7402, HepG2, HCT116 Caco2) using MTT assay in vitro explored. Among them, thirteen compounds (17a, 17b, 18a, 19a, 19b, 20a, 20b, 21a, 21b, 22a, 22b, 23a, 23b) exhibited significant inhibitory activity the tested lines. The structure-activity relationships (SARs) derivatives discussed. promising candidate compound 17a...
Abstract Together with five known sesquiterpenes, EtOH extraction of Laurencia saitoi yielded four new compounds, including three sesquiterpenes and one norsesquiterpene derivative. Their structures relative configurations were elucidated by spectroscopic methods, 1D‐ 2D‐NMR ( 1 H, H‐COSY, HMQC, HMBC, NOESY), as well low‐ high‐resolution mass‐spectrometric analyses.
A study on the secondary metabolites of
Astaxanthin (AST) characteristics and pigment productivity of Adonis amurensis, one the few AST-producing higher plants, have not yet been studied extensively. In this study, geometrical optical isomers AST in different parts A. amurensis flower were determined detail, followed by a separation all-trans using HPLC chromatography. extracted from accounted for 1.31% dry weight (dw) mainly existed di-esterified form (>86.5%). The highest concentration was found upper red part petal (3.31%...
Protein tyrosine phosphatase (PTP) 1B (PTP1B) plays a critical role in the regulation of obesity, Type 2 diabetes mellitus and other metabolic diseases. However, drug candidates exhibiting PTP1B selectivity oral bioavailability are currently lacking. Here, enzyme inhibitory characteristics pharmacological benefits 3-bromo-4,5-bis(2,3-dibromo-4,5-dihydroxybenzyl)-1,2-benzenediol (BDB) were investigated vitro vivo.Surface plasmon resonance (SPR) assay was performed to validate direct binding...