A5100333043- Algal biology and biofuel production
- Marine and coastal plant biology
- Marine and coastal ecosystems
- Photosynthetic Processes and Mechanisms
- Aquatic Ecosystems and Phytoplankton Dynamics
- Antioxidant Activity and Oxidative Stress
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Aquaculture Nutrition and Growth
- Microbial Community Ecology and Physiology
- T-cell and B-cell Immunology
- Geology and Paleoclimatology Research
- Marine Biology and Ecology Research
- Geological formations and processes
- Psoriasis: Treatment and Pathogenesis
- Microbial Metabolic Engineering and Bioproduction
- Geological and Geophysical Studies
- Seaweed-derived Bioactive Compounds
- Biocrusts and Microbial Ecology
- Coral and Marine Ecosystems Studies
- RNA Interference and Gene Delivery
- Phagocytosis and Immune Regulation
- Marine Bivalve and Aquaculture Studies
- Aquaculture disease management and microbiota
Institute of Oceanology
2016-2025
Chinese Academy of Sciences
2016-2025
Chinese PLA General Hospital
2025
Qingdao National Laboratory for Marine Science and Technology
2016-2024
Northwest A&F University
2017-2023
South China Sea Institute Of Oceanology
2018-2023
Shandong Provincial QianFoShan Hospital
2022
Shandong First Medical University
2022
Haier Group (China)
2021-2022
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2022
Interleukin (IL)-27 is the newest member of IL-12 family heterodimeric cytokines composed Epstein-Barr virus–induced gene 3 and p28 chains. IL-27 not only plays an important role in regulation differentiation naive T helper cells but also possesses antiinflammatory properties. early product activated monocytes/macrophages dendritic cells. However, mechanisms whereby inflammatory signals stimulate production have been explored. In this study, we investigated transcriptional mouse macrophages...
TH17 cells are recognized as a unique subset of T helper that have critical roles in the pathogenesis autoimmunity and tissue inflammation. Although RORγt is necessary for generation cells, molecular mechanisms underlying functional diversity not fully understood. Here we show member interferon regulatory factor (IRF) family transcription factors, IRF8, has role silencing TH17-cell differentiation. Mice with conventional knockout, well cell-specific deletion, Irf8 gene exhibited more...
Interleukin (IL)-12 is a heterodimeric cytokine consisting of the p40 and p35 chains encoded on separate chromosomes. Coordinated expression two constituent genes crucial for appropriate immune responses in timing, location, magnitude. Interferon (IFN)-γ priming IL-12 production by macrophages represents an important physiological process vivo escalated cellular response to microbial infections. We provide evidence that IFN regulatory factor (IRF)-1–deficient have selective impairment mRNA...
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of the p35 and p40 subunits. It produced by antigen-presenting cells plays critical role in host defense against intracellular microbial infection control malignancy via its ability to stimulate both innate adaptive immune effector cells. The potency IL-12 renders itself stringent regulation timing, locality magnitude production during an response. Subversion delicate balance frequently leads immunologic disorders. In this article,...
Interleukin (IL)-23, a new member of the IL-12 family, plays central role in Th17 immune response and autoimmune diseases. It is clear that activated macrophages dendritic cells produce IL-23, but molecular mechanisms whereby inflammatory signals stimulate IL-23 expression are not fully understood. We demonstrate induction p19 gene by LPS depends on TLR4 MyD88 pathways. All three MAPK pathways (ERK, JNK, p38) lipopolysaccharide (LPS) stimulation were shown to exert positive effect...
Abstract Tumor cell–derived molecules such as cytokines and lipid mediators play a critical role in inducing chronic inflammation the tumor microenvironment. We found that Th17 cells were increased peripheral blood, spleen, tissues of mammary gland tumor-bearing mice. The cell survival factor, IL-23, was also overexpressed isolated from mice human breast cancer patients. Soluble secreted cells, but not normal epithelial induced IL-23 protein secretion dendritic via induction p19 mRNA...
Previously it has been shown that green microalga Chlamydomonas reinhardtii is capable of prolonged H2 photoproduction when deprived sulfur. In addition to sulfur deprivation (-S), sustained in C. cultures can be achieved under phosphorus-deprived (-P) conditions. Similar deprivation, phosphorus limits O2 evolving activity algal cells and causes other metabolic changes are favorable for photoproduction. Although significant advances have recently realized fresh water microalgae, relatively...
The cell transformation from green motile cells to non-motile and astaxanthin accumulation can be induced in the alga Haematococcus pluvialis cultured outdoors. In initial 3 d of incubation (cell phase), light absorption photosynthetic electron transport became more efficient. After five days (astaxanthin per active reaction center (ABS/RC) increased, but efficiency (ψo) quantum yield (φEo) decreased with increased time, indicating that capacity energy utilization significantly during...
Abstract IL-12 is a principal activator of both innate and adaptive immunity against infectious agents malignancies. Regulation proinflammatory gene expression in phagocytes by the anti-inflammatory cytokine IL-10 represents major homeostatic process underlying host-pathogen host-self interactions. Delineation signaling pathway crucial to understanding immunological regulatory networks. In this study, we report that c-musculoaponeurotic fibrosarcoma (Maf) induce their mutual inflammatory...
The Nod-like receptor proteins Nod1 and Nod2 participate in innate immune responses against bacteria through intracellular detection of peptidoglycan, a component bacterial cell wall. Recent evidence has demonstrated that stimulates the release chemokines attract neutrophils at site infection, such as CXCL8/IL-8 humans, CXCL1/keratinocyte-derived chemokine CXCL2/MIP-2 mice. We aimed to determine whether Nod could trigger CCL5/RANTES, known number cells, but not neutrophils. Our results...
We compared the carotenoids in tissues of various organs from four shrimps cultured China, Penaeus monodon Fabricius, 1978, Fenneropenaeus chinensis Osbeck, 1765, Litopenaeus vannamei Boone, 1931, and Exopalaemon carinicauda Holthuis, 1950. The carotenoid levels vary greatly depending on species sampled, with highest found cephalothorax L. (295.20 mg kg(-1)), lowest abdominal muscle (2.12 kg(-1)). Astaxanthin, mainly esterified (47.69-95.56%), but also unesterified (4.445-2.31%), was...
Interferon regulatory factor 1 (IRF-1) is an important transcription in interferon γ (IFNγ)-mediated signaling the development and function of NK cells cytotoxic T lymphocytes. RANTES (regulated on activation normal cell expressed secreted; CCL5) a member CC chemokine family proteins, which strongly chemoattractant for several immune types host defense against infectious agents cancer. However, role IFNγ IRF-1 regulation gene expression their operative mechanisms macrophages have not been...
Interferon regulatory factor (IRF) family members, especially interferon factor-1 (IRF-1) and factor-8 (IRF-8 or ICSBP), play important roles in signaling a wide range of host responses to infection tumor growth. Interleukin-27 (IL-27), as member the IL-12 cytokine family, not only acts proinflammatory that regulates differentiation naive T helper cells but also possesses anti-inflammatory properties. IL-27 consists EBI3 (Epstein-Barr virus-induced gene 3) p28 subunits. Our previous work has...
IL-23 plays an essential role in maintenance of IL-17-producing Th17 cells that are involved the pathogenesis several autoimmune diseases. Regulation is tightly controlled by multiple factors such as IL-27 and IFN-γ. However, detailed mechanisms responsible for IFN-γ-mediated cell inhibition still largely unknown. In this study, we demonstrate IFN-γ differentially regulates IL-12 production both dendritic macrophages. suppresses expression selectively targeting p19 mRNA stability through its...
The differentially co-expressed proteins in N-deprived and N-enriched I. galbana were comparatively analyzed by using two dimensional electrophoresis (2-DE) matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight-mass spectrometry (MALDI-TOF/TOF-MS) with the aim of better understanding lipid metabolism this oleaginous microalga. Forty-five 900 protein spots showed dramatic changes compared cells. Of these, 36 27 successfully identified. identified classified into seven...