A5006625650- Aquatic Ecosystems and Phytoplankton Dynamics
- Marine and coastal ecosystems
- Environmental Toxicology and Ecotoxicology
- Biocrusts and Microbial Ecology
- Autophagy in Disease and Therapy
- Aquatic Ecosystems and Biodiversity
- Algal biology and biofuel production
- Mycotoxins in Agriculture and Food
- Mitochondrial Function and Pathology
- Effects and risks of endocrine disrupting chemicals
- Pharmaceutical and Antibiotic Environmental Impacts
- Heavy metals in environment
- Marine Toxins and Detection Methods
- Receptor Mechanisms and Signaling
- Toxic Organic Pollutants Impact
- bioluminescence and chemiluminescence research
- Microplastics and Plastic Pollution
- Calcium signaling and nucleotide metabolism
- Cardiovascular Function and Risk Factors
- Neurofibromatosis and Schwannoma Cases
- Evolution and Genetic Dynamics
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Cardiac electrophysiology and arrhythmias
- Coccidia and coccidiosis research
New York Institute of Technology
2014-2025
Technical University of Denmark
2023-2024
Nanjing Normal University
2015-2024
Institute of Quality Standards and Testing Technology for Agro Products
2020-2024
Chinese Academy of Agricultural Sciences
2020-2024
National Engineering Research Center for Wheat
2019-2024
Henan Agricultural University
2020-2024
Guangxi University
2024
Yanbian University
2024
Institute of Apiculture Research
2024
Heart failure (HF) is the end-stage of cardiovascular diseases, which associated with a high mortality rate and readmission rate. Household early diagnosis real-time prognosis HF at bedside are significant importance. Here, we developed highly sensitive quantitative household platform (termed as UC-LFS platform), integrating smartphone-based reader multiplexed upconversion fluorescent lateral flow strip (LFS). Dual-color core–shell nanoparticles (UCNPs) were synthesized probes for...
Cardiac autophagy is inhibited in type 1 diabetes. However, it remains unknown if the reduced contributes to pathogenesis of diabetic cardiomyopathy. We addressed this question using mouse models with gain- and loss-of-autophagy. Autophagic flux was hearts when measured at multiple time points after diabetes induction by streptozotocin as assessed protein levels microtubule-associated light chain 3 form 2 (LC3-II) or GFP-LC3 puncta absence presence lysosome inhibitor bafilomycin A1....
Doxorubicin (Dox) is a widely used antineoplastic agent that can cause heart failure. Dox cardiotoxicity closely associated with mitochondrial damage. Mitochondrial fission and mitophagy are quality control mechanisms normally help maintain pool of healthy mitochondria. However, unchecked may compromise the viability cardiomyocytes, predisposing them to cell death. Here, we tested this possibility by using Dox-treated H9c2 cardiac myoblast cells expressing either mitochondria-targeted...
Most coastal waters are at risk from microplastics, which vary in concentration and size. Rotifers, as important primary consumers linking producers higher trophic consumers, usually coexist with the harmful alga Phaeocystis microplastics waters; this coexistence may interfere rotifer life-history traits ingestion of Phaeocystis. To evaluate effects on rotifers, we designed a series experiments concerning Brachionus plicatilis rotifer-Phaeocystis (predator-prey) population dynamics under...
Background— In α1-AR knockout (α1ABKO) mice that lacked cardiac myocyte α1-adrenergic receptor (α1-AR) binding, aortic constriction induced apoptosis, dilated cardiomyopathy, and death. However, it was unclear whether these effects were attributable to a lack of α1-ARs the α1A, α1B, or both subtypes mediated protection. Therefore, we investigated α1A α1B subtype–specific survival signaling in cultured myocytes test for direct protective effect myocytes. Methods Results— We α1ABKO...
The c-Jun NH2-terminal kinase (JNK) branch of the mitogen-activated protein signaling cascade has been implicated in regulation apoptosis a variety mammalian cell types. In heart, disagreement persists concerning role that JNKs may play regulating apoptosis, since both pro- and antiapoptotic regulatory functions have reported cultured cardiomyocytes. Here we report first analysis cardiomyocyte death due to JNK inhibition or activation vivo using genetically modified mice. Three separate...
We previously identified an α1-AR-ERK (α1A-adrenergic receptor–extracellular signal-regulated kinase) survival signaling pathway in adult cardiac myocytes. Here, we investigated localization of α1-AR subtypes (α1A and α1B) how their influences Using binding assays on myocyte subcellular fractions or a fluorescent antagonist, localized endogenous α1-ARs to the nucleus wild-type To clarify α1 subtype localization, reconstituted cultured α1A- α1B-AR double knockout myocytes using α1-AR–green...
The transcription factor GATA-4 protects cardiomyocytes against doxorubicin-induced cardiotoxicity. Here, we report the identification of Bcl2 as a direct target gene GATA4 that may mediate prosurvival function in cardiomyocytes. transcript and protein levels were reduced by doxorubicin neonatal rat ventricular (NRVC) mouse heart determined RT-PCR Western blot analysis. reduction was prevented overexpression NRVC transgenic heart. Also, expression increased baseline 30% 2.7-fold heart,...
Global warming and increased nutrient fluxes cause cyanobacterial blooms in freshwater ecosystems. These phenomena have the concern for human health ecosystem services. The mass occurrences of toxic cyanobacteria strongly affect zooplankton communities, especially unselective filter feeder Daphnia. However, molecular mechanisms toxicity remain poorly understood. This study is first to combine established body growth rate (BGR), which an indicator life-history fitness, with differential...
Hawthorn ( Crataegus pinnatifida Bunge. var. major ) is an edible and medicinal fruit that very common in food traditional Chinese medicine. Corosolic acid (CA), a pentacyclic triterpenoid, which active component of hawthorn ), has been exhibiting various pharmacological activities such as antidiabetic, antibacterial, anticancer, antiinflammatory, antioxidant effects. The study aimed to evaluate the effect CA on non‐alcoholic steatohepatitis (NASH) mice induced by 60 kcal% high‐fat diet...
Abstract The green alga Scenedesmus obliquus can form inducible defensive morphs under grazing threat. Costs and trade-offs of defense are expected to accompany the benefits morphs, but hard detect nutrient-sufficient experimental conditions. To test existence costs associated with defense, we cultured S. along resource availability gradients in presence or absence infochemical cues from Daphnia , measured strength colony formation fitness characters. Under lowest phosphorous concentration,...
Hyperglycemia-induced mitochondrial dysfunction plays a key role in the pathogenesis of diabetic cardiomyopathy. Injured segments are separated by fission and eliminated autophagic sequestration subsequent degradation lysosome, process termed mitophagy. However, it remains poorly understood how high glucose affects activities of, relationship between, mitophagy cardiomyocytes. In this study, we determined functional roles hyperglycemia-induced cardiomyocyte injury. High (30 mM, HG) reduced...
Abstract Background Choroid plexus (CP) tumors are rare brain neoplasms that mainly affect the pediatric population. Unlike benign CP papilloma (CPP), carcinoma (CPC) is an aggressive cancer with a dismal survival rate. Despite chromosome-wide rearrangements, drivers of most remain elusive except recurrent alterations in TP53. Studies signaling dysregulation may bring biological understanding these malignancies. Previous studies implicated NOTCH tumors; we developed mouse models driven by...
Toxic Microcystis bloom is a tough environment problem worldwide. Microcystin highly toxic and an easily accumulated secondary metabolite of that threatens water safety. Biodegradation microcystin by protozoan grazing promising efficient biological method, but the mechanism in this process still unclear. The present study aimed to identify potential pathways involved resisting degrading flagellates through transcriptomic analyses. A total 999 unigenes were significantly differentially...
Abstract Cyanobacteria have become more prevalent than other phytoplankton in freshwater assemblages during summer. In such conditions, cyanobacterial traits may reduce zooplankton fitness and the energy flow efficiency from primary producers to aquatic herbivores. Cladocerans, as dominant grazers ecosystems, exhibit clonal variation their tolerance cyanobacteria with an increasing gradient eutrophication history. Hitherto, research on full modes of action (MoAs) Daphnia differences toxic...