A5103077333- Neurological Disease Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Autophagy in Disease and Therapy
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Calcium signaling and nucleotide metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Chemotherapy-induced cardiotoxicity and mitigation
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Aquatic Ecosystems and Phytoplankton Dynamics
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Tea Polyphenols and Effects
- Peroxisome Proliferator-Activated Receptors
- Sirtuins and Resveratrol in Medicine
- Alzheimer's disease research and treatments
- Cardiac Health and Mental Health
- Bioactive natural compounds
- Adenosine and Purinergic Signaling
- Ginkgo biloba and Cashew Applications
- Postharvest Quality and Shelf Life Management
- Polysaccharides and Plant Cell Walls
- Biomedical Research and Pathophysiology
Hubei University of Science and Technology
2013-2024
Hebei Medical University
2023-2024
Foshan University
2024
Langfang Normal University
2024
Hangzhou First People's Hospital
2022-2023
Xianning Central Hospital
2022
Feng Chia University
2022
Hangzhou Normal University
2018-2019
Icahn School of Medicine at Mount Sinai
2019
Renmin Hospital of Wuhan University
2017
Doxorubicin (Dox) is a widely used antineoplastic agent that can cause heart failure. Dox cardiotoxicity closely associated with mitochondrial damage. Mitochondrial fission and mitophagy are quality control mechanisms normally help maintain pool of healthy mitochondria. However, unchecked may compromise the viability cardiomyocytes, predisposing them to cell death. Here, we tested this possibility by using Dox-treated H9c2 cardiac myoblast cells expressing either mitochondria-targeted...
Cyanobacteria-derived microcystin-leucine-arginine (MCLR), commonly characterized as a hepatotoxin, has recently been found to show neurotoxicity, but the exact mechanism is still unknown. To further our understanding of neurotoxic effects MCLR and mechanisms behind it, we used two-dimensional gel electrophoresis mass spectrometry analysis identify global protein profiles associated with MCLR-induced neurotoxicity. MCLR-treated hippocampi showed alterations in proteins involved cytoskeleton,...
The function of curcumin on NADPH oxidase-related ROS production and cardiac apoptosis, together with the modulation protein signalling pathways, was investigated in cardiomyocytes. Primary cultures neonatal rat cardiomyocytes were exposed to 30 mmol/L high glucose or without curcumin. Cell viability, superoxide formation, expression oxidase subunits, potential regulatory molecules, Akt GSK-3 β , assessed Cardiomyocytes exposure led an increase both cell apoptosis intracellular levels, which...
Hepatocellular carcinoma (HCC) is one of the most common cancers and fourth leading cause death in men. YEATS domain containing 2 (YEATS2) gene encodes a scaffolding subunit ATAC complex. We found that YEATS2 was upregulated HCC tissues associated with poor prognosis. However, role remains unclear. The purpose this study to investigate effect on progression elucidate its related mechanisms. overexpression promoted tumor cell proliferation, migration, invasion through PI3K/AKT signaling...
Theaflavin, a major constituent of black tea, possesses biological functions such as the antioxidative, antiviral, and anti-inflammatory ones. The purpose this study was to verify whether theaflavin reduces focal cerebral ischemia injury in rat model middle artery occlusion (MCAO). Male Sprague-Dawley rats were anesthetized subjected 2 hours MCAO followed 24 reperfusion. Theaflavin administration (5, 10, 20 mg/kg, i.v.) ameliorated infarct edema volume. inhibited leukocyte infiltration...
Microcystin-LR (MCLR) is a commonly encountered blue–green algal hepatotoxin and known inhibitor of cellular protein phosphatase. However, little about its neurotoxicity. By using Morris water maze, histopathological biochemical analysis, we investigated MCLR-induced neurotoxicity on the hippocampus rat brain. After rats were intrahippocampally injected with MCLR (1 10 μg/L), their learning memory function was greatly impaired, suggesting neurotoxic potential MCLR. Meanwhile, obvious...
Background: Doxorubicin (DOX) is a potent chemotherapeutic agent with limited usage due to its cumulative cardiotoxicity. The Na + /H exchanger isoform 1 (NHE1) known regulator of oxidative stress, inflammation, and apoptosis. present study was designed investigate the possible protective effect cariporide (CAR), selective inhibitor NHE1, against DOX-induced cardiotoxicity in rats. Methods: Male Sprague-Dawley rats were intraperitoneally injected DOX induce cardiac toxicity CAR given orally...
Recent studies showed that cyanobacteria-derived microcystin-leucine-arginine (MCLR) can cause hippocampal pathological damage and trigger cognitive impairment; but the underlying mechanisms have not been well understood. The objective of present study was to investigate mechanism MCLR-induced deficit; with a focus on endoplasmic reticulum (ER) stress. Morris water maze test electrophysiological demonstrated MCLR caused spatial memory injury in male Wistar rats; which could be inhibited by...
To observe effect of sophora japonica total flavonoids on pancreas, kidney tissue morphology streptozotocin-induced diabetic mice model. Mice received tail vein injection streptozotocin (60 mg/kg) for diabetes modeling. The model were divided into five groups, to be respectively fed with high, middle and small doses solution, metformin solution saline the same volume. Another blank control group was set administered once a day 30 consecutive days, euthanatized after fasting blood glucose...
Green tea has been receiving considerable attention as a possible neuroprotective agent against neurodegenerative disease. Epigallocatechin-3-gallate (EGCG) is the major compound of green tea. Calcium signaling profound effects on almost all aspects neuronal function. Using digital calcium imaging and patch-clamp technique, we determined EGCG Ca2+ signals in hippocampal neurons. The results indicated that caused dose-dependent increase intracellular ([Ca2+]i). This [Ca2+]i was blocked by...
Diselenide-containing paclitaxel nanoparticles (SePTX NPs) indicated selectivity of cytotoxicity between cancerous and normal cells in our previous work.Herein, the mechanism is revealed by molecular biology detail.Cancer were treated with SePTX NPs cell proliferation was measured using 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide (MTT) assay morphology.Measurement reactive oxygen species (ROS) levels biochemical parameters employed to monitor oxidative stress...
Article Metformin Inhibits Autophagy, Mitophagy and Antagonizes Doxorubicin-Induced Cardiomyocyte Death Jennifer Van 1, Younghee Hahn Brett Silverstein Cairong Li 2, Fei Cai Jia Wei 3, Lokesh Katiki Puja Mehta Katherine Livatova Jaclyn DelPozzo Tamayo Kobayashi Yuan Huang Satoru Qiangrong Liang * 1 Department of Biomedical Sciences, New York Institute Technology, College Osteopathic Medicine, Old Westbury, 10001, United States 2 Clinical Medical College, Hubei University Science Xianning...
Intraplaque neovascularization is often associated with plaque formation, development and instability, clinical symptoms in atherosclerosis. The aim of the present study was to investigate a new strategy for treating athrosclerosis by ultrasound-targeted microbubble delivery (UTMD) targeting intraplaque an APOE-deficient mouse model atherosclerosis.A atherosclerosis induced feeding Apoe-/- mice hypercholesterolemic diet verified hematoxylin eosin staining intercellular adhesion molecule 1...
Neurotoxicity of microcystin-leucine-arginine (MCLR) has been widely reported. However, the mechanism is not fully understood. Using primary hippocampal neurons, we tested hypothesis that MCLR-triggered activation in intracellular free calcium concentration ([Ca 2+ ] i ) induces death neurons. Microcystin-leucine-arginine inhibited cell viability at a range 0.1 to 30 μmol/L and caused dose-dependent increase [Ca . This was observed Ca -free media blocked by an endoplasmic reticulum pump...
Ample clinical case reports suggest a high incidence of cardiomyopathy in diabetes mellitus (DM). Recent evidence supports an essential role trehalose (TLS) cardiomyocyte survival signaling. Our previous study found that prokineticin2 (PK2) was involved the process diabetic (DCM). The present examined protective effects and mechanisms TLS on DM‐induced injury mice H9c2 cardiomyocytes. C57BL/6J were intraperitoneally injected with 50 mg·kg -1 ·d streptozotocin for five consecutive days to...
Theaflavin, a major constituent of black tea, possesses biological functions such as the antioxidative, antiviral, and anti-inflammatory ones. The purpose this study was to verify whether theaflavin reduces focal cerebral ischemia injury in rat model middle artery occlusion (MCAO). Male Sprague-Dawley rats were anesthetized subjected 2 hours MCAO followed 24 reperfusion. Theaflavin administration (5, 10, 20 mg/kg, IV) ameliorated infarct edema volume. inhibited leukocyte infiltration...