A5100362876- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- biodegradable polymer synthesis and properties
- Advanced Polymer Synthesis and Characterization
- Genetic factors in colorectal cancer
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Bioactive natural compounds
- Lung Cancer Treatments and Mutations
- Supramolecular Self-Assembly in Materials
- Natural product bioactivities and synthesis
- Advanced Drug Delivery Systems
- Tea Polyphenols and Effects
- Hepatitis B Virus Studies
- Phytochemistry and Biological Activities
- Cholesterol and Lipid Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Biological and pharmacological studies of plants
- Medicinal plant effects and applications
- Prostate Cancer Treatment and Research
- Porphyrin and Phthalocyanine Chemistry
- Phytochemical compounds biological activities
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Second Xiangya Hospital of Central South University
2023-2024
Central South University
2023-2024
Shenyang Pharmaceutical University
2022-2024
Institute of Hematology & Blood Diseases Hospital
2020-2023
Southeast University
2023
Guang’anmen Hospital
2017-2023
China Academy of Chinese Medical Sciences
2015-2023
University of Science and Technology Beijing
2022
State Ethnic Affairs Commission
2022
Cancer-associated fibroblasts (CAFs), an important type of stromal cells in the tumor microenvironment (TME), are responsible for creating physical barriers to drug delivery and penetration tissues. Thus, effectively downregulating CAFs destroy barrier may allow enhanced accumulation therapeutic drugs, thereby improving outcomes. Herein, a matrix metalloproteinase (MMP)-triggered dual-targeting hybrid micelle-in-liposome system (RPM@NLQ) was constructed sequentially deliver quercetin (Que)...
Modulating the inflammatory microenvironment can inhibit process of diseases (IDs). A tri-cross-linked microenvironment-responsive hydrogel with ideal mechanical properties achieves triggerable and sustained drug delivery regulates microenvironment. Here, this study develops an (OD-PP@SeNPs) composed phenylboronic acid grafted polylysine (PP), oxidized dextran (OD), selenium nanoparticles (SeNPs). The introduction SeNPs as initiators nano-fillers into results in extra cross-linking polymer...
Seven new triterpenes, inonotusol A–G (1–7), one diterpene, inonotusic acid (8), and 22 known compounds were isolated from Inonotus obliquus. Their structures elucidated on the basis of spectroscopic analysis, including homonuclear heteronuclear correlation NMR (1H–1H COSY, ROESY, HSQC, HMBC) experiments. In in vitro assays, 6 8–16 showed hepatoprotective effects against d-galactosamine-induced WB-F344 cell damage, with inhibitory 34.4% to 81.2%. Compounds 7, 17, 18 exhibited selective...
ABSTRACT The purpose of this article is to investigate the effects nano‐tianium dioxide (nano‐TiO 2 ) on high‐amylose starch/polyvingl alcohol (PVA) blend films prepared by a solution casting method. results show that at concentration 0.6% nano‐TiO , film demonstrated best tensile strength 9.53 MPa, and elongation break was noted as 49.50%. optical transmittance decreased water resistance improved with further increase . Using techniques Fourier transform infrared spectroscopy (FTIR),...
The interactions between nanoparticles (NPs) and plasma proteins form a protein corona around NPs after entering the biological environment, which provides new properties to mediates their with cells barriers. Given inevitable interactions, we regard nanoparticle‒protein as tool for designing corona-mediated drug delivery systems. Herein, demonstrate successful application of brain-targeted nanomicelles in treatment glioma, loading them paclitaxel (PTX), decorating amyloid β-protein (Aβ)-CN...
Prostate cancer (PC) is one of the common malignant tumors male genitourinary system. Here, we constructed PTX@ZIF-8, which a metal-organic-framework-encapsulated drug delivery nanoparticle with paclitaxel (PTX) as model drug, and further modified synthesized peptide dimer (Di-PEG2000-COOH) onto surface PTX@ZIF-8 to prepare nanotargeted system (Di-PEG@PTX@ZIF-8) for treatment prostate cancer. This study investigated morphology, particle size distribution, zeta potential, loading,...
Theaflavin, a major constituent of black tea, possesses biological functions such as the antioxidative, antiviral, and anti-inflammatory ones. The purpose this study was to verify whether theaflavin reduces focal cerebral ischemia injury in rat model middle artery occlusion (MCAO). Male Sprague-Dawley rats were anesthetized subjected 2 hours MCAO followed 24 reperfusion. Theaflavin administration (5, 10, 20 mg/kg, i.v.) ameliorated infarct edema volume. inhibited leukocyte infiltration...
Four new 2-arylbenzofuran derivatives, moracins V—Y (1—4), together with two known compounds, moracin N (5) and P (6), were isolated from the leaves of Morus alba L. Their structures elucidated by spectroscopic analysis. Moracins X (3) Y (4) represent unusual substituted group compared which genus Morus. Compounds 2—5 evaluated for cytotoxicity against several human cancer cell lines.
Designing a smart nanotheranostic system has recently attracted tremendous attention and is highly desirable for realizing targeted cancer therapy early diagnosis. Herein we report the fabrication of using multiresponsive gatekeeping protocol mesoporous silica nanoparticles (MSN). Acid, oxidative stress redox sensitive manganese oxide (MnO x) coated superparamagnetic iron nanoparticle (SPION) were employed as nanolids to regulate camptothecin drug release from channels achieve responsive...
In this work, a sustainable method to prepare functional cellulose nanocrystals (CNCs) and nanofibrils (CNFs) using formic acid (FA) (a recoverable organic acid) was established. After FA hydrolysis, the obtained CNCs could be well dispersed in DMAC. Thus, CNC products fibrous cellulosic solid residue (FCSR) DMAC easily separated by conventional centrifugal process, collected FCSR further fibrillated CNFs with relatively low-intensity mechanical fibrillation process. The isolated showed high...
A new contact-killing and non-leaching antimicrobial polymer was prepared by a robust, efficient orthogonal click-chemistry.
Oral chemotherapy is preferred for patients with cancer owing to its multiple advantages, including convenience, better patient compliance, and improved safety. Nevertheless, various physical barriers exist in this route that hamper the development of oral chemotherapeutic formulations, destruction drugs gastrointestinal tract (GIT), low permeability enterocytes, short residence time intestine. To overcome these limitations, it necessary design an efficient drug delivery system high efficacy...
The extremely low bioavailability of oral paclitaxel (PTX) mainly due to the complicated gastrointestinal environment, obstruction intestinal mucus layer and epithelium barrier. Thus, it is great significance construct a coordinative delivery system which can overcome multiple physicochemical obstacles simultaneously. In this work, high-density PEGylation-based glycocholic acid-decorated micelles (PTX@GNPs) was constructed by novel polymer, 9-Fluorenylmethoxycarbonyl-polyethylene acid...
Star-shaped polymers provide more terminal groups, and are promising for application in drug-delivery systems.A new series of six-arm star-shaped poly(lactic-co-glycolic acid) (6-s-PLGA) was synthesized by ring-opening polymerization. The structure properties the 6-s-PLGA were characterized carbon-13 nuclear magnetic resonance spectroscopy, infrared gel permeation chromatography, differential scanning calorimetry. Then, paclitaxel-loaded nanoparticles (6-s-PLGA-PTX-NPs) prepared under...
Atherosclerosis is a chronic disease characterized by lipid deposition and inflammatory response. NOD-, LRR- pyrin domain-containing protein 3 (NLRP3) inflammasome-facilitated responses are crucial in the pathogenesis of atherosclerosis, thus new therapeutic approaches emerging that target NLRP3 inflammation. Here, we explored anti-atherosclerotic effect mechanisms rutaecarpine derivative, 5-deoxy-rutaecarpine (R3) vitro vivo. R3 treatment attenuated atherosclerosis development increased...
Docetaxel (DTX), a semisynthetic analogue of paclitaxel, is often used to treat cancers. Owing its poor aqueous solubility, the current formulation DTX for clinical applications involves using high surfactant and ethanol concentrations, causing hypersensitivity reactions. To overcome this issue, we developed reduction-responsive prodrug encapsulated within human serum albumin (HSA) nanoparticles (DTX–SS–COOH/HSA NPs). First, was conjugated undecanoic acid through disulfide bond (DTX–SS–COOH)...
A new 2-arylbenzofuran derivative, mornigrol D (1), along with two flavones, G (2) and H (3), six known compounds, norartocarpetin (4), dihydrokaempferol (5), albanin (6), E (7), moracin M (8), albafuran C (9), were isolated from the barks of Morus nigra. Their structures elucidated by spectroscopic analysis. Compounds 1 9 showed antioxidative activities in vitro inhibition ratios 98 99% at concentration 10− 4 mol/l, 74 75% 5 mol/l. In addition, compounds potent anti-inflammatory (inhibition...