A5102902623- Sepsis Diagnosis and Treatment
- Computational Drug Discovery Methods
- Plant-based Medicinal Research
- Atherosclerosis and Cardiovascular Diseases
- Folate and B Vitamins Research
- Inflammasome and immune disorders
- Dialysis and Renal Disease Management
- COVID-19 Clinical Research Studies
- Renal function and acid-base balance
- Cholesterol and Lipid Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Glutathione Transferases and Polymorphisms
- Pharmacological Effects of Natural Compounds
- Long-Term Effects of COVID-19
- Hemodynamic Monitoring and Therapy
Chongqing University
2024-2025
Huazhong University of Science and Technology
2024
Chongqing Emergency Medical Center
2024
Tongji Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
Aim The association between red cell distribution width—albumin ratio (RAR) and the risk of all-cause mortality in intensive care unit (ICU) patients with heart failure remains uncertain. This study aimed to investigate this association. Methods Clinical data from MIMIC-Ⅳ (version 2.2) database was utilized for analysis ICU failure. Patients were categorized into quartiles (Q1–Q4) based on RAR levels. Kaplan-Meier survival multivariate adjusted Cox regression models employed assess levels...
Abstract Background Sleep apnoea is recognized as a cardiovascular risk factor, especially in individuals with existing heart conditions. Understanding the direct causal relationship between sleep and arrhythmia, while accounting for confounding factors such coronary artery disease, hypertension, failure, myocardial infarction, essential effective management. Methods Utilizing data from FinnGEN study spanning 1998 to 2019, we conducted Mendelian randomization analysis on European cohort...
Atherosclerosis is a chronic disease characterized by lipid deposition and inflammatory response. NOD-, LRR- pyrin domain-containing protein 3 (NLRP3) inflammasome-facilitated responses are crucial in the pathogenesis of atherosclerosis, thus new therapeutic approaches emerging that target NLRP3 inflammation. Here, we explored anti-atherosclerotic effect mechanisms rutaecarpine derivative, 5-deoxy-rutaecarpine (R3) vitro vivo. R3 treatment attenuated atherosclerosis development increased...
Abstract Despite the progressive decline in virulence of novel coronavirus, there has been no corresponding reduction its associated hospital mortality. Our aim was to redefine an accurate predictor mortality risk COVID-19 patients, enabling effective management and resource allocation. We conducted a retrospective analysis 2917 adult Chinese patients diagnosed with who were admitted our during two waves epidemics, involving Beta Omicron variants. Upon admission, NT-proBNP levels measured,...
The associations between the albumin-corrected anion gap (ACAG) and all-cause mortality in patients with congestive heart failure intensive care unit remain uncertain. This study aimed to investigate this unknown. MIMIC-IV (version 3.0) database was used analyze critically ill failure. Patients were grouped into tertiles (T1-T3) on basis of ACAG. association ACAG levels 1-year assessed using Kaplan-Meier survival analyses, multivariate adjusted Cox regression models, restricted cubic spline...
Objectives Glutathione S-transferase alpha (GSTα) is an important antioxidant enzyme closely associated with the onset and progression of neurodegenerative diseases. The alterations in GSTα protein levels Alzheimer’s disease their impact on cognitive abilities remain unclear. Thus, investigating fluctuations mild impairment (MCI) (AD) essential. Methods DATA were enrolled from Disease Neuroimaging Initiative (ADNI) database, we studied healthy individuals (as controls, a total 54), patients...
SARS-CoV-2 main protease (Mpro) is responsible for polyprotein cleavage to release non-structural proteins (nsps) viral genomic RNA replication, and its homologues are absent in human cells. Therefore, Mpro has been regarded as one of the ideal drug targets treatment coronavirus disease 2019 (COVID-19). In this study, we first combined fluorescence polarization (FP) technique with biotin-avidin system (BAS) develop a novel sandwich-like FP screening assay quick discovery inhibitors from...