A5100649504- Cardiac, Anesthesia and Surgical Outcomes
- Glioma Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Hip and Femur Fractures
- Liver Disease Diagnosis and Treatment
- Anesthesia and Pain Management
- Neuroscience and Neuropharmacology Research
- RNA Interference and Gene Delivery
- Folate and B Vitamins Research
- Cardiac Ischemia and Reperfusion
- Anesthesia and Sedative Agents
- Acute Ischemic Stroke Management
- Pneumonia and Respiratory Infections
- Cancer-related molecular mechanisms research
- Cancer-related cognitive impairment studies
- Gut microbiota and health
- Respiratory viral infections research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Neurological Disease Mechanisms and Treatments
- Crystallography and molecular interactions
- Acute Kidney Injury Research
Chinese PLA General Hospital
2012-2025
Chinese Academy of Sciences
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Huashan Hospital
2023-2024
Fudan University
2007-2024
People's Liberation Army No. 150 Hospital
2024
Chinese People's Liberation Army
2023-2024
Creative Commons
2019-2024
Baylor College of Medicine
2014-2024
Beijing Institute of Technology
2005-2024
Abstract The gut microbiota (GM) is related to obesity and other metabolic diseases. To detect GM markers for in patients with different abnormalities investigate their relationships clinical indicators, 1,914 Chinese adults were enrolled 16S rRNA gene sequencing this retrospective study. Based on composition, Random forest classifiers constructed screen the (Group OA) or without diseases O) from healthy individuals H), high accuracies observed discrimination of Group O OA (areas under...
Abstract The outbreak of the new Coronavirus disease, COVID-19, has been involved in 77,262 cases China as well 27 other countries February 24, 2020. Because virus is novel to human beings, and there no vaccine yet available, every individual susceptible can become infected. Healthcare workers are at high risk, unfortunately, more than 3,000 healthcare have Anesthesiologists among who an even higher risk becoming infected because their close contact with patients potential exposure...
Abstract Background Ischemic stroke is the second leading cause of death globally. The narrow time window for administering effective thrombolytic therapy motivates search alternative prevention strategies. Microglia and astrocyte activation-mediated inflammation play a pivotal role in ischemic injury. Cottonseed oil (CSO) has been shown to exert anti-inflammatory effects against peripheral tissue injury, although CSO mostly used as solvent lipid-soluble drugs. However, neuroprotection not...
Human tumors harbor a plethora of microbiota. It has been shown that the composition and diversity intratumor microbiome are significantly associated with survival patients pancreatic ductal adenocarcinoma (PDAC). However, association in Chinese as well effect different microorganisms on inhibiting tumor growth unclear. In this study, we collected samples resected from long-term short-term PDAC survivors performed 16S rRNA amplicon sequencing. We found time were different, differential...
Modulating the inflammatory microenvironment can inhibit process of diseases (IDs). A tri-cross-linked microenvironment-responsive hydrogel with ideal mechanical properties achieves triggerable and sustained drug delivery regulates microenvironment. Here, this study develops an (OD-PP@SeNPs) composed phenylboronic acid grafted polylysine (PP), oxidized dextran (OD), selenium nanoparticles (SeNPs). The introduction SeNPs as initiators nano-fillers into results in extra cross-linking polymer...
Postoperative pain poses a significant challenge to the healthcare system and patient satisfaction is associated with chronic long-term narcotic use. However, systemic assessment of quality postoperative management in China remains unavailable.In this cross-sectional study, we analyzed data collected from nationwide registry, Acute Pain Study (CAPOPS), between September 2019 August 2021. Patients aged 18 years or above were required complete self-reported outcome questionnaire on first day...
Glioblastoma (GBM) is the most common and aggressive type of glioma has poorest survival. However, a small percentage patients with GBM survive well beyond established median. Therefore, identifying genetic variants that influence this number unusually long-term survivors may provide important insight into tumor biology treatment.Among 590 primary GBM, we evaluated associations survival 100 top-ranking susceptibility single nucleotide polymorphisms from our previous genome-wide association...
This study aimed to investigate the clinical prognostic values of preoperative systemic-immune-inflammation index (SII) in older patients undergoing non-cardiac surgery, using perioperative ischemic stroke as primary outcome.This retrospective cohort included who underwent surgery between January 2008 and August 2019. The were divided into SII < 583 ≥ group according optimal cut-off value. outcome interest was within 30 days after surgery. Primary, sensitivity, subgroup analyses performed...
Abstract Aims To compare the performance of logistic regression and machine learning methods in predicting postoperative delirium (POD) elderly patients. Method This was a retrospective study perioperative medical data from patients undergoing non‐cardiac non‐neurology surgery over 65 years old January 2014 to August 2019. Forty‐six variables were used predict POD. A traditional five models (Random Forest, GBM, AdaBoost, XGBoost, stacking ensemble model) compared by area under receiver...
Abstract Background Postoperative cognitive impairment are common neural complications in older surgical patients and exacerbate the burden of medical care on families society. Methods A total 140 who were scheduled for elective orthopaedic surgery or pancreatic with general anaesthesia randomly assigned to Group S I a 1:1 allocation. Patients received intranasal administration 400 μL normal saline 40 IU/400 insulin, respectively, once daily from 5 minutes before induction until 3 days...
Glioma is the most common type of adult brain tumor and glioblastoma, its aggressive form, has a dismal prognosis. Receptor tyrosine kinases such as epidermal growth factor receptor (EGFR, ERBB2, ERBB3, ERBB4) family, vascular endothelial (VEGFR), play central role in progression. We investigated genetic variants EGFR, VEGFR their ligands, EGF VEGF on glioma glioblastoma risk. In addition, we evaluated association newly discovered family genes known to interact with EGFR: LRIG2 LRIG3...
To investigate the impact of fecal microbiota transplantation (FMT) treatment on allergic colitis (AC) and gut (GM).We selected a total 19 AC infants, who suffered from severe diarrhea/hematochezia, did not relieve completely after routine therapy or cannot adhere to therapy, were free organ congenital malformations other contraindications for FMT. Qualified donor-derived stools collected injected infants via rectal tube. Clinical outcomes follow-up observations noted. Stools ten before FMT,...
Non-invasive dynamic tracking of lysosomes and their interactions with other organelles is important for the study lysosomal function related diseases. However, many fluorescent dyes developed so far to target cannot be used monitor these processes due high concentrations required imaging, long cell penetration times, non-ideal photostability. In this regard, we synthesized three targeting probes large Stokes shifts, good stability, brightness. The Q-P-ARh dye, by us first time, can stain at...
Alzheimer's disease (AD) is a progressive neurodegenerative with insidious onset, and the deposition of amyloid-β (Aβ) believed to be one main cause. Fluorescence imaging promising technique for this task, but Aβ gold standard probe ThT developed based on still has shortcomings. The development new fluorescent detect plaques thought essential. Herein, series red near-infrared emitting probes QNO-ADs newly quinoxalinone skeleton are designed plaques. They all demonstrate excellent optical...
Prostate cancer (PC) is one of the common malignant tumors male genitourinary system. Here, we constructed PTX@ZIF-8, which a metal-organic-framework-encapsulated drug delivery nanoparticle with paclitaxel (PTX) as model drug, and further modified synthesized peptide dimer (Di-PEG2000-COOH) onto surface PTX@ZIF-8 to prepare nanotargeted system (Di-PEG@PTX@ZIF-8) for treatment prostate cancer. This study investigated morphology, particle size distribution, zeta potential, loading,...