A5100351305- Neuroscience and Neuropharmacology Research
- Sphingolipid Metabolism and Signaling
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid Membrane Structure and Behavior
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Crystallization and Solubility Studies
- Protein Tyrosine Phosphatases
- Curcumin's Biomedical Applications
- Axon Guidance and Neuronal Signaling
- Anesthesia and Sedative Agents
- Autoimmune and Inflammatory Disorders Research
- Bioinformatics and Genomic Networks
- Acne and Rosacea Treatments and Effects
- Influenza Virus Research Studies
- Pharmacological Effects of Natural Compounds
- Advanced Drug Delivery Systems
- Genomics and Chromatin Dynamics
- Neuroblastoma Research and Treatments
- Caveolin-1 and cellular processes
- Multiple Sclerosis Research Studies
- Liver Disease Diagnosis and Treatment
Sichuan University
2016-2025
State Key Laboratory of Biotherapy
2016-2024
West China Hospital of Sichuan University
2018-2023
Binzhou University
2023
Binzhou Medical University
2023
Chengdu Center for Disease Control and Prevention
2021-2022
Beijing Polytechnic
2022
China Pharmaceutical University
2020
Washington University in St. Louis
2013
Tianjin University of Science and Technology
2011
Alzheimer's disease (AD) is a progressive neurodegenerative with insidious onset, and the deposition of amyloid-β (Aβ) believed to be one main cause. Fluorescence imaging promising technique for this task, but Aβ gold standard probe ThT developed based on still has shortcomings. The development new fluorescent detect plaques thought essential. Herein, series red near-infrared emitting probes QNO-ADs newly quinoxalinone skeleton are designed plaques. They all demonstrate excellent optical...
Favipiravir, the first RNA polymerase inhibitor approved to treat resistant influenza, has been reported be associated with central nervous system (CNS) side effects, particularly anxiety-like behavior; nevertheless, underlying mechanism remains largely unknown. In this study, we investigated effect of favipiravir on neurobehavior mice, and combined lipidomics transcriptomics analysis explore effect. behavioral tests, mice displayed behaviors after oral administration (200 mg/kg) for 7 days...
Herein we disclose the first example of transition-metal-catalyzed oxidative coupling/annulation simple benzoic acids with terminal alkynes via C–H activation. A range aromatic carboxylic and have been found to be viable substrates in this reaction, providing a efficient method for synthesis diverse 3-ylidenephthalides complete Z selectivity.
Fingolimod (FTY720) is an orally available sphingosine‐1‐phosphate (S1P) receptor modulator reducing relapse frequency in patients with relapsing–remitting multiple sclerosis (RRMS). In addition to immunosuppression, neuronal protection by FTY720 has also been suggested, but remains controversial. Axial and radial diffusivities derived from vivo diffusion tensor imaging (DTI) were employed as noninvasive biomarkers of axonal injury demyelination assess experimental autoimmune...
Biallelic genetic variants in N -acetylneuraminic acid synthase ( NANS ), a critical enzyme endogenous sialic biosynthesis, are clinically associated with neurodevelopmental disorders. However, the mechanism underlying neuropathological consequences has remained elusive. Here, we found that mutation resulted absence of both and protein polysialylation cortical organoids notably reduced proliferation expansion neural progenitors. dysregulated migration differentiation, disturbed synapse...
Neuronal activation is required for the formation of drug-associated memory, which critical development, persistence, and relapse drug addiction. Nevertheless, metabolic mechanisms underlying energy production neuronal remain poorly understood. In study, a large-scale proteomics analysis lysine crotonylation (Kcr), type protein posttranslational modification (PTM), reveals that cocaine promoted Kcr in hippocampal dorsal dentate gyrus (dDG). We find predominantly discovered few enzymes...
Sevoflurane exposure in the neonatal period causes long-term developmental neuropsychological dysfunction, including memory impairment and anxiety-like behaviors. However, molecular mechanisms underlying such effects have not been fully elucidated. In this study, we investigated effect of to sevoflurane on neurobehavioral profiles adolescent rats, applied an integrated approach lipidomics proteomics investigate network implicated dysfunction. We found that caused cognitive social behavior...
The expression of linear DNA sequence is precisely regulated by the three-dimensional (3D) architecture chromatin. Morphine-induced aberrant gene networks neurons have been extensively investigated; however, how morphine impacts 3D genomic still unknown. Here, we applied digestion-ligation-only high-throughput chromosome conformation capture (DLO Hi-C) technology to investigate effects on chromatin primate cortical neurons. After receiving continuous administration for 90 days rhesus...
Cefepime exhibits a broad spectrum of antimicrobial activity and thus is widely used treatment for severe bacterial infections. Adverse effects on the central nervous system (CNS) have been reported in patients treated with cefepime. Current explanation adverse neurobehavioral effect cefepime mainly attributed to its ability cross blood-brain barrier competitively bind GABAergic receptor; however, underlying mechanism largely unknown. In this study, mice were intraperitoneally administered...
The antitumor mechanism of curcumin is unclear, especially in hepatocellular carcinoma (HCC) cells. To clarify the action effective treatment HCC, targets were screened and validated. Candidate genes for HCC using traditional Chinese medicine systems pharmacology (TCMSP) database validated Cancer Genome Atlas (TCGA) database. correlation mRNA expression levels between key candidate was identified TCGA liver (LIHC) dataset. effects on prognosis analyzed to identify target gene curcumin, which...
The optimal prescription of tanshinone Ⅱ_A(TSN)-glycyrrhetinic acid(GA) solid lipid nanoparticles(GT-SLNs) was explored and evaluated in vivo vitro, its effect on acne after oral administration investigated. preparation processing were optimized verified by single factor response surface methodology. vitro release GA TSN GT-SLNs determined ultra-performance liquid chromatography(UPLC). investigated the levels sex hormones mice, ear swelling model, tissue changes sebaceous glands,...
Abstract The expression of linear DNA sequences is precisely regulated by the three–dimensional (3D) architecture chromatin. Morphine-induced aberrant gene networks neurons have been extensively investigated; however, how morphine impacts 3D genomic neuorns still unknown. Here, we applied digestion-ligation-only high-throughput chromosome conformation capture (DLO Hi-C) technology to investigate affection on chromatin primate cortical neurons. After receiving continuous administration for 90...
The expression of linear DNA sequences is precisely regulated by the three-dimensional (3D) architecture chromatin. Morphine-induced aberrant gene networks neurons have been extensively investigated; however, how morphine impacts 3D genomic still unknown. Here, digestion-ligation-only high-throughput chromosome conformation capture technology was applied to investigate chromatin brain cortical in non-human primates treated with for 90 days continuously. We discovered that dramatically...
Abstract Cefepime exhibits a broad spectrum of antimicrobial activity and thus is widely used for severe bacterial infection. Adverse effects on the central nervous system (CNS) have been reported in patients treated with cefepime. Current explanation neurobehavioral effect cefepime mainly attributes to its ability across blood-brain barrier competitively bind GABAergic receptor; however, underlying mechanism largely unknown. In this study, mice were intraperitoneally administered 80 mg/kg...
Background: Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are key regulators during the process of synaptic plasticity in major depression disorder (MDD). SynDIG1 functions as an atypical AMPAR auxiliary subunit and regulates AMPARcontent; however, role MDD remains elusive. Methods: We used a chronic social defeat stress model to investigate effects underlying mechanism. Findings: In present study, we found that expression was significantly increased neurons...