A5029780947- Microbial Natural Products and Biosynthesis
- Neuroscience and Neuropharmacology Research
- Heavy Metal Exposure and Toxicity
- Autophagy in Disease and Therapy
- Marine Sponges and Natural Products
- Trace Elements in Health
- Sphingolipid Metabolism and Signaling
- Lipid Membrane Structure and Behavior
- Hippo pathway signaling and YAP/TAZ
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Calcium signaling and nucleotide metabolism
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Curcumin's Biomedical Applications
- Stress Responses and Cortisol
- Cancer-related gene regulation
- Endoplasmic Reticulum Stress and Disease
- Synthetic Organic Chemistry Methods
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- ATP Synthase and ATPases Research
Oregon State University
2015-2024
Chengdu University of Traditional Chinese Medicine
2019-2024
Yanshan University
2024
Sichuan University
2017-2023
State Key Laboratory of Biotherapy
2019-2023
Huahai Pharmaceutical (China)
2023
First Affiliated Hospital of Nanchang University
2019-2021
Nanchang University
2019-2021
Chengdu Center for Disease Control and Prevention
2021
Qingdao Municipal Hospital
2020
Coibamide A (CbA) is a marine natural product with potent antiproliferative activity against human cancer cells and unique selectivity profile. Despite promising antitumor activity, the mechanism of cytotoxicity specific cellular target CbA remain unknown. Here, we develop an optimized synthetic photoaffinity probe (photo-CbA) use it to demonstrate that directly targets Sec61α subunit Sec61 protein translocon. binding results in broad substrate-nonselective inhibition ER import cell lines....
Cadmium (Cd) is a common heavy metal contamination that highly toxic to liver. Puerarin (PU), potent free radical scavenger, has been shown exert cytoprotective effect in numerous pathological processes. However, whether PU affords protection against Cd-induced hepatotoxicity remains unclear be known. Here, we aimed investigate the protective of on an immortalized mouse hepatocyte line, AML-12. First, cytotoxicity AML-12 cells was obviously ameliorated by treatment. Also, apoptotic cell...
Abstract Mitochondrial fusion and fission dynamic are critical to the myocardial protection against ischaemia‐reperfusion injury. Notch1 signalling plays an important role in heart development, maturation repair. However, of mitochondrial remains elusive. Here, we isolated cells from rats established injury (IRI) model. We modulated Notch1, MFN1 DRP1 expression levels via infection with recombinant adenoviruses. The results showed that improves cell viability myocardiocytes exposed IRI....
Abstract The abuse potential of ketamine limits its clinical application, but the precise mechanism remains largely unclear. Here we discovered that significantly remodels endocannabinoid-related lipidome and activates 2-arachidonoylglycerol (2-AG) signaling in dorsal striatum (caudate nucleus putamen, CPu) mice. Elevated 2-AG CPu is essential for psychostimulant reinforcing effects ketamine, whereas blockade cannabinoid CB1 receptor, a predominant attenuates ketamine-induced remodeling...
Mandelalides A–D (1–4) are macrocyclic polyketides known to have an unusual bioactivity profile influenced by compound glycosylation and growth phase of cultured cells. The isolation characterization additional natural congeners, mandelalides E–L (5–12), the supply synthetic compounds 1 12, as well seco-mandelalide A methyl ester (13), now facilitated mechanism action structure–activity relationship studies. Glycosylated effective inhibitors aerobic respiration in living Macrolides 2 inhibit...
Our understanding of autophagy and lysosomal function has been greatly enhanced by the discovery natural product structures that can serve as chemical probes to reveal new patterns signal transduction in cells. Coibamide A is a cytotoxic marine induces mTOR-independent an adaptive stress response precedes cell death. Autophagy-related (ATG) protein 5 (ATG5) required for coibamide-induced but not apoptosis. Using wild-type autophagy-deficient mouse embryonic fibroblasts (MEFs) we demonstrate...
The mandelalides comprise a family of structurally complex marine macrolides that display significant cytotoxicity against several human cancer cell lines. Presented here is full account on the development an Anion Relay Chemistry (ARC) strategy for total synthesis (-)-mandelalides A and L, two most potent members mandelalide family. design implementation three-component type II ARC/cross-coupling protocol four-component I ARC union permits rapid access respectively to key tetrahydrofuran...
Jizanpeptins A–E (1–5) are micropeptin depsipeptides isolated from a Red Sea specimen of Symploca sp. cyanobacterium. The planar structures the jizanpeptins were established using NMR spectroscopy and mass spectrometry contain 3-amino-6-hydroxy-2-piperidone (Ahp) as one eight residues in typical motif, well side chain terminal glyceric acid sulfate moiety. absolute configurations assigned combination Marfey's methodology chiral-phase HPLC analysis hydrolysis products compared to commercial...
The mandelalides are complex macrolactone natural products with distinct macrocycle motifs and a bioactivity profile that is heavily influenced by compound glycosylation. Mandelalides A B direct inhibitors of mitochondrial ATP synthase (complex V) therefore more toxic to mammalian cells an oxidative metabolic phenotype. To provide further insight into the pharmacology mandelalides, we studied AMP-activated protein kinase (AMPK) energy stress pathway report mandelalide indirect activator...
Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading chronic worldwide. Emerging evidence suggests a close crosstalk between iron status and metabolic syndrome. Therefore, this cohort study aimed to investigate relationship serum all-cause mortality in individuals with MASLD. Methods A total of 3393 subjects MASLD identified by ultrasound from Third National Health Nutrition Examination Survey (NHANES III) were included analysis. Iron indicators iron,...
Objective. To investigate the effect of cantharidin on DNA damage in hepatocellular carcinoma cells and its possible mechanism. Methods. Cell proliferation assay terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) were used to analyze effects cell apoptosis cells. The expression levels markers H2AX P21 analyzed by qRT-PCR. KDM4A H3K36me3 was observed western blot. regulated siRNA or plasmid transfection. induced liver cancer after overexpression addiction KDM4A....
Recent investigations have revealed that puerarin (PU) alleviates cadmium (Cd)-caused hepatic damage via inhibiting oxidative stress. Mitochondria are dynamic organelles and play a critical part in regulating the occurrence of stress, but role mitochondria protection PU against hepatocellular caused by Cd exposure remains unknown. Thus, this study was aimed to clarify issue using mouse hepatocyte AML-12 cell line. Transmission electron microscopy analysis firstly showed prevents Cd-induced...
Osteosarcoma is the most common type of bone cancer in dogs and humans, with significant numbers patients experiencing treatment failure disease progression. In our search for new approaches to treat osteosarcoma, we previously detected multiple chaperone proteins surface-exposed proteome canine osteosarcoma cells. present study, characterized expression representative chaperones find evidence stress adaptation cells relative osteogenic progenitors from normal bone. We compared cytotoxic...
The development, persistence and relapse of drug addiction require memory that generally develops with administration-paired contextual stimuli. Adult hippocampal neurogenesis (AHN) contributes to cocaine formation; however, the underlying mechanism remains unclear. Male mice expression Tau was significantly decreased during cocaine-associated formation. Genetic overexpression four microtubule-binding repeats (4R Tau) in hippocampus disrupted by suppressing AHN. Furthermore, 4R directly...
Cefepime exhibits a broad spectrum of antimicrobial activity and thus is widely used treatment for severe bacterial infections. Adverse effects on the central nervous system (CNS) have been reported in patients treated with cefepime. Current explanation adverse neurobehavioral effect cefepime mainly attributed to its ability cross blood-brain barrier competitively bind GABAergic receptor; however, underlying mechanism largely unknown. In this study, mice were intraperitoneally administered...