A5037524811- Neuropeptides and Animal Physiology
- Chemokine receptors and signaling
- Angiogenesis and VEGF in Cancer
- Receptor Mechanisms and Signaling
- Cell Adhesion Molecules Research
- Cancer, Stress, Anesthesia, and Immune Response
- Peptidase Inhibition and Analysis
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Nitric Oxide and Endothelin Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Signaling Pathways in Disease
- Lung Cancer Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroendocrine regulation and behavior
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Memory and Neural Mechanisms
- Lipid metabolism and biosynthesis
- HER2/EGFR in Cancer Research
- Macrophage Migration Inhibitory Factor
- Advanced Biosensing Techniques and Applications
- Nuclear Receptors and Signaling
Sichuan University
2015-2025
West China Hospital of Sichuan University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
West China Medical Center of Sichuan University
2024
Lu'an First People's Hospital
2023
State Key Laboratory of Biotherapy
2017-2022
South China Institute of Collaborative Innovation
2019
West China Second University Hospital of Sichuan University
2017
Pyroptosis is a newly identified form of cell death that closely correlated with many diseases. Recent studies have indicated the inflammation in pyroptosis would accelerate generation reactive oxygen species (ROS). In addition, intracellular viscosity another key microenvironmental parameter reflects physiological and pathological states early stage, hypochlorous acid (HOCl), as an important ROS, also plays significant roles variety pathologies. However, fluctuation HOCl process still...
Sepsis is a serious systemic inflammatory disease that frequently results in death. Early diagnosis and timely targeted interventions could improve the therapeutic effect. Recent work has revealed reactive oxygen species (ROS) endoplasmic reticulum (ER) hypoxia-induced endothelial injury play significant roles sepsis. However, relationship between levels of peroxynitrite (ONOO–) as well different states sepsis remain unexplored. Herein, we developed unique two-photon fluorescent probe...
Sepsis is a life-threatening condition caused by dysregulated host responses to infection. Widespread vascular hyperpermeability and "cytokine storm" are two pathophysiological hallmarks of sepsis. Here, we show that intermedin (IMD), member the calcitonin family, alleviates organ injury decreases mortality in septic mice concurrently alleviating leakage inflammatory responses. IMD promotes relocation endothelial cadherin through Rab11-dependent pathway dynamically repair disrupted junction....
Sunitinib, a receptor tyrosine kinase (RTK) inhibitor that targets multiple receptors such as vascular endothelial growth factor (VEGFRs), was approved for cancer treatment in 2006. However, it unsuccessful treating certain cancers, particularly metastatic breast (MBC), and the mechanism underlying this "sunitinib resistance" remains unclear. Herein, we investigated whether sunitinib-associated inferior survival benefit MBC due to sunitinib-induced cell (EC) injury or EC senescence. 4T1...
Objective— Intermedin plays an important role in vascular remodeling and significantly improves blood perfusion, but the precise mechanism remains unclear. Herein, we aimed to define whether lumen enlargement is responsible for intermedin-increased perfusion explore underlying cellular molecular mechanisms. Approach Results— To study of intermedin, generated IMD-KO ( Adm2 −/− ) mice using CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/clustered repeat–associated 9)...
Background and objectives Disease severity prognosis of coronavirus disease 2019 (COVID-19) with other viral infections can be affected by the oropharyngeal microbiome. However, limited research had been carried out to uncover how these diseases are differentially microbiome patient. Here, we aimed explore characteristics microbiota COVID-19 patients compare them those similar symptoms. Methods was diagnosed in through detection severe acute respiratory syndrome 2 (SARS-CoV-2) quantitative...
Abstract Background Chronic obstructive pulmonary disease (COPD) contributes to the incidence and prognosis of lung cancer. The presence COPD significantly increases risk squamous cell carcinoma (LSCC). may promote an immunosuppressive microenvironment in LSCC by regulating expression immune‐inhibitory factors T cells, although mechanisms remain unclear. In this study, we aimed decipher tumour signature for with at a single‐cell level. Methods We performed RNA sequencing on tissues from or...
Glioblastoma (GBM) is the most malignant tumor in human brain. High invasiveness of this main reason causing treatment failure and recurrence. Previous study has found that LACTB a novel suppressor breast cancer. Moreover, function other tumors mechanisms involving were also reported. However, role relevant GBM invasion remains to be revealed. Our aim investigate migration invasion. We was downregulated gliomas compared normal brain tissues. Overexpression suppressed LN229 U87 cell lines....
Abstract As one of the most malignant cancer types, hepatocellular carcinoma (HCC) is highly invasive and capable metastasizing to distant organs. Intermedin (IMD), an endogenous peptide belonging calcitonin family, has been suggested playing important roles in cell survival invasion, including HCC. However, how IMD affects behavior HCC cells underlying mechanisms have not fully elucidated. Here, we show that maintains homeostatic state by activating ERK1/2-EGR1 (early growth response 1)...
Metabolic reprogramming plays a critical role in tumorigenesis and tumor progression. The metabolism the proliferation of tumors are regulated by both intrinsic factors within availability metabolites microenvironment (TME). metabolic niche TME is primarily orchestrated at 3 levels: 1) regulation to tumors, 2) interaction between cells T cells, macrophages, stromal 3) heterogeneity tissue space. Herein, we provided concise overview various regulatory modes observed cells. Additionally,...
Glioblastoma multiforme (GBM; grade IV glioma) is the most malignant type of primary brain tumor and characterized by rapid proliferation invasive growth. Intermedin (IMD) an endogenous peptide belonging to calcitonin gene-related family has been reported play important role in cell survival invasiveness several types cancers. In this study, we found that expression level IMD was positively related malignancy gliomas. The highest GBM, indicating may glioma malignancy. increased ability cells...
The development, persistence and relapse of drug addiction require memory that generally develops with administration-paired contextual stimuli. Adult hippocampal neurogenesis (AHN) contributes to cocaine formation; however, the underlying mechanism remains unclear. Male mice expression Tau was significantly decreased during cocaine-associated formation. Genetic overexpression four microtubule-binding repeats (4R Tau) in hippocampus disrupted by suppressing AHN. Furthermore, 4R directly...
Although anti-angiogenic (AA) therapy is widely used in clinical practice, it often challenged by insufficient efficacy and intrinsic resistance. Some studies have reported that AA can even increase tumor metastasis. However, whether this due to a specific drug causing metastasize or because the theory has some "inherent vice" may inevitably lead dissemination remains mystery. Herein, we designed model completely blocks blood supply using physical barrier examine behavior such circumstances....
To create a closed vascular system, angiogenic sprouts must meet and connect in process called vessel fusion, which is prerequisite for establishment of proper blood flow nascent vessels. However, the molecular machinery underlying this remains largely unknown. Herein, we report that intermedin (IMD), calcitonin family member, promotes fusion by inducing endothelial cells (ECs) to enter "ready-to-anchor" state. IMD cadherin (VEC) accumulation at potential site facilitate anchoring...