A5100367624- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Respiratory viral infections research
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Gut microbiota and health
- Phytochemistry and Biological Activities
- SARS-CoV-2 and COVID-19 Research
- Calcium signaling and nucleotide metabolism
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Traumatic Brain Injury Research
- COVID-19 and healthcare impacts
- Multiple and Secondary Primary Cancers
- Hepatitis C virus research
- Retinal and Optic Conditions
- Acupuncture Treatment Research Studies
- COVID-19 diagnosis using AI
- Advanced Clustering Algorithms Research
- Head and Neck Cancer Studies
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Infectious Diseases and Mycology
- Liver Diseases and Immunity
Sichuan University
2015-2024
West China Hospital of Sichuan University
2015-2024
East China Normal University
2024
Xinjiang Normal University
2024
Moffitt Cancer Center
2015-2022
New Jersey Institute of Technology
2021
Xijing Hospital
2020
Air Force Medical University
2020
Suizhou Central Hospital
2020
First Affiliated Hospital of Kunming Medical University
2020
The regulated clearance of mitochondria is a well recognized but poorly understood aspect cellular homeostasis, and defects in this process have been linked to aging, degenerative diseases, cancer. Mitochondria are recycled through an autophagy-related process, reticulocytes, which completely eliminate their during maturation, provide physiological model study phenomenon. Here, we show that mitochondrial reticulocytes requires the BCL2-related protein NIX (BNIP3L). Mitochondrial does not...
Background and objectives Disease severity prognosis of coronavirus disease 2019 (COVID-19) with other viral infections can be affected by the oropharyngeal microbiome. However, limited research had been carried out to uncover how these diseases are differentially microbiome patient. Here, we aimed explore characteristics microbiota COVID-19 patients compare them those similar symptoms. Methods was diagnosed in through detection severe acute respiratory syndrome 2 (SARS-CoV-2) quantitative...
To overcome drug resistance caused by apoptosis deficiency in patients with non-small cell lung carcinoma (NSCLC), there is a need to identify other means of triggering apoptosis-independent cancer death. We are the first report that isogambogenic acid (iso-GNA) can induce autophagic death human NSCLC cells. Several features iso-GNA-treated cells indicated iso-GNA induced First, was no evidence or cleaved caspase 3 accumulation and activation. Second, treatment formation vacuoles, increased...
Thousands of results scientific publications on the topic COVID-19 have emerged within a short time, raising significant challenges for scholars to organize research, or even synthesize knowledge in timely comprehensive manner. To facilitate this, we developed geospatial and semantic mapping platform search these large unmapped digital collections. The map visualizes research topics based customized natural language processing algorithms, which helps users identify their content specific...
MYC family oncoproteins are regulators of metabolic reprogramming that sustains cancer cell anabolism. Normal cells adapt to nutrient-limiting conditions by activating autophagy, which is required for amino acid (AA) homeostasis. Here we report the autophagy pathway suppressed Myc in normal B cells, premalignant and neoplastic Eμ-Myc transgenic mice, human MYC-driven Burkitt lymphoma. suppresses antagonizing expression function transcription factor EB (TFEB), a master regulator autophagy....
Primary carcinoid tumor of the gallbladder is rare and comprises less than 1% all tumors. Preoperative diagnosis difficult. The imageology findings are similar to those in other cancers. A 46-year-old woman was hospitalized with a preoperative carcinoma, patient referred for surgical opinion laparotomy subsequently performed. 4 × 5 cm mass found within gallbladder, located on free surface body fundus gallbladder. Neither metastases nor direct invasion liver found. entire were excised intact....
Infection with non-tuberculous mycobacteria (NTM) is relatively rare in areas that are high-endemic for tuberculosis. We identified 126 strains of NTM respiratory specimens collected by the Chinese Nationwide Survey 2000, Beijing Tuberculosis and Thoracic Tumour Institution, Guangzhou Hospital. Species diagnosis was attained sequencing 16S-rDNA complemented phenotypic characterization when necessary. Mycobacterium avium-intracellulare-complex - well known as a potential pulmonary pathogen...
<title>Abstract</title> Purpose This study aims to compare the clinical outcomes and healthcare costs of COVID-19 patients treated in either conventional or remodeled respiratory departments at a large medical center China. Methods Using propensity score matching, we selected between December 2022 February 2023. We compared all-cause in-hospital mortality as primary outcome, along with secondary including length hospitalization, rates critical illness complications, related treatments,...
A new simple and efficient RP-HPLC-UV method was developed for the simultaneous analysis of nine isoflavonoids in Huangqi-Gegen herbal pair. Effective chromatographic separation these components achieved on a Kromasil C18 column (4.6×250 mm, i.d.; 5 μm) with gradient elution methanol 0.2% formic acid aqueous solution at flow rate 1.0 mL/min 60 min. Detection performed 250nm. The proved to be linear ranges 81.28-406.4, 670.4-3352, 136.96-684.8, 33.376-166.88, 22.848-114.24, 10.176- 50.88,...
This study was conducted to investigate oropharyngeal microbiota alterations during the progression of coronavirus disease 2019 (COVID-19) by analyzing these infection and clearance processes severe acute respiratory syndrome 2 (SARS-CoV-2). The diagnosis COVID-19 confirmed using positive SARS-CoV-2 quantitative reverse transcription polymerase chain reaction (RT-qPCR). in abundance, diversity, potential function microbiome were identified metatranscriptomic sequencing analyses swab...
<div>Abstract<p>MYC family oncoproteins are regulators of metabolic reprogramming that sustains cancer cell anabolism. Normal cells adapt to nutrient-limiting conditions by activating autophagy, which is required for amino acid (AA) homeostasis. Here we report the autophagy pathway suppressed Myc in normal B cells, premalignant and neoplastic Eμ-<i>Myc</i> transgenic mice, human MYC-driven Burkitt lymphoma. suppresses antagonizing expression function transcription...
Non-alcoholic fatty liver disease (NAFLD) is characterized by increased fat depositions in the while patients do not have drinking history. NAFLD has a prevalence of 10%~40% global, 25%~26% Western populations. From 2004 to 2013, numbers new on waitlist who had NASH 170% America. The China 20%. With decrease HBV and HCV increase diabetes mellitus type 2 obesity, will become most common chronic over next 20 years. related end-stage indication transplantation. In this paper, epidemiological...
Abstract Objective: Novel coronavirus (nCoV, SARS-CoV-2) infection becomes a world-wide epidemic which has complicated and diversified symptoms, but no special treatment. In this study, diagnosis treatment of family clustering nCoV were analyzed. Methods: The Sichuan Suining Central Hospital received 11 patients with confirmed virus from 4 families during January 23 rd , 2020 to February 20 th 2020. Their clinical conditions changes disease state reviewed in the present study. Results : all...