A5061363517- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Supramolecular Self-Assembly in Materials
- DNA and Nucleic Acid Chemistry
- Analytical Chemistry and Sensors
- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Lung Cancer Treatments and Mutations
- Chemical Synthesis and Analysis
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Heterocycles
- Cancer therapeutics and mechanisms
- Immunotherapy and Immune Responses
- Advanced Polymer Synthesis and Characterization
- Phytochemistry and biological activities of Ficus species
- Photochromic and Fluorescence Chemistry
- Supramolecular Chemistry and Complexes
- RNA Interference and Gene Delivery
- Bacteriophages and microbial interactions
- CAR-T cell therapy research
- Hydrogels: synthesis, properties, applications
Sichuan University
2014-2025
West China Hospital of Sichuan University
2021-2024
University of Münster
2019
CeNTech
2018-2019
Chengdu University
2018
Henan University of Science and Technology
2018
Shaanxi University of Technology
2017
Nankai University
2010-2014
West China Medical Center of Sichuan University
2013-2014
Abstract The precise, controllable, and safe application of pesticides can effectively reduce pesticide consumption minimize chemical pollution at the source. Here, a light‐responsive controlled‐release system with flexible control, precise release, easy recovery, suitability for future in aquatic environments is proposed. precisely controls release through composite nanochannel membrane (CTC@SNM/PET) reactive coumarin derivatives (CTC) as gating molecules. prepared has an ultrathin...
Abstract Interleukin (IL)-27, a newly discovered IL-12 family cytokine, is composed of p28 and EBI3. In this study, CD11c-p28 f/f conditional knockout mice were generated to delete specifically in dendritic cells (DCs). We demonstrated that the absence DC-derived p28, these highly susceptible both low higher concentrations concanavalin A (ConA) (5 mg/kg or 10 mg/kg), with extremely early steady high levels interferon-γ (IFN-γ) sera. Neutralizing IFN-γ prevented ConA-induced liver damage...
Abstract Critical roles of IL-27 in autoimmune diseases and infections have been reported; however, the contribution endogenous to tumor progression remains elusive. In this study, by using IL-27p28 conditional knockout mice, we demonstrate that is critical protective immune response against methyl-cholanthrene–induced fibrosarcoma transplanted B16 melanoma, dendritic cells (DCs) are primary source. DC-derived required for shaping microenvironment inducing CXCL-10 expression myeloid-derived...
Real-time quantitative detection of ultraviolet (UV) radiation dose is vitally important in life and industry. Herein, we report a novel system for real-time monitoring UV based on photochromic hydrogel photo-resistance. The probe composed UV-responsive poly(N,N-dimethylacrylamide)-ammonium molybdate tetrahydrate that rapidly significantly changes color responding to dose, red filter instantaneously amplifies the UV-radiation-induced change signal, photo-resistance transforms signal into...
Determining mutations in the kinase domain of epidermal growth factor receptor (EGFR) is critical for effectiveness EGFR tyrosine inhibitors (TKIs) lung cancer. Yet, DNA-based sequencing analysis tumor samples time-consuming and only provides gene mutation information on EGFR, making it challenging to design effective EGFR-TKI therapeutic strategies. Here, we present a new image-based method involving rational quenched probe based identify mutant proteins, which permits specific "no-wash"...
Supramolecular self-assembly is not only one of the chemical roots biological structure but also drawing attention in different industrial fields. Here we study mechanism formation a complex flower-shaped supramolecular pyrimido[4,5-d]pyrimidine nucleosides by dynamic light scattering, scanning electron microscopy, differential calorimetry, nuclear magnetic resonance and X-ray analysis. Upon removing hydroxyl group sugars, superstructures can be produced. These works demonstrate that indeed...
ABSTRACT The effects of aflatoxin B 1 (AFB ) were studied using the HepG2 cell line. Cytotoxicity, apoptosis and p53 expression assessed after exposure to different concentrations AFB (0–100 μ m its two types degradation products, namely mixtures photodegradation products in water (Pw) peanut oil (Po) for time periods (0, 24, 48 h). After cells these compounds times concentrations, cytotoxicity Pw Po decreased approximately 40 100% compared with , respectively. protein significantly ‐exposed...
ABSTRACT Tregs (Foxp3+CD4+) are enriched in tumors to foster a tolerant microenvironment that inhibits antitumor immune response. IL-27 is reported regulate the development and function of vitro vivo; however, effects endogenous on tumor remain elusive. We demonstrated absence DC-derived IL-27, were decreased significantly transplanted B16 melanoma, EL-4 lymphoma, MCA-induced fibrosarcoma by using IL-27p28 conditional KO mice. Further studies revealed promoted expression CCL22, which...
Herein, we report the crystal structure and characterization of mono-6-(l-aminopropanol)-deoxy-β-cyclodextrin (L n @β-CD). A highly efficient, in situ generated catalyst, PdCl2(L @β-CD), was synthesized for palladium-catalyzed cross-coupling reactions under mild reaction conditions, use this catalyst Suzuki cross-couplings investigated. Low palladium loadings 0.01 mol % @β-CD) (Pd accounted approximately 8.4% by mass) were found to be efficient water afforded corresponding biaryl compounds...
Abstract Pigmentary coloration can produce viewing angle-independent uniform colors via light absorption by chromophores. However, due to the limited diversity in changes of molecular configuration chromophores undergo color change, existing materials cannot a wide range visible with tunable saturation and transmittance. Herein, we propose novel strategy create highly We fabricated hydrogel poly (acrylamide- co -dopamine acrylamide) networks swollen Fe 3+ -containing glycerol/water which...
ABSTRACT CD8+ T cells play an important role in immune regulation and effective responses against tumor cells, viral infection, intracellular pathogens. In this report, using tiger or 10BiT mice, we defined a population of IL-10-producing that were induced by IL-4. These IL-10+CD8+ possessed strong inhibitory effect on the CD4+ cell proliferation IL-10-dependent contact-dependent fashion. comparison with IL-10−CD8+ expressed array Th2-like cytokines (IL-4, IL-5), perforin, granzymes, as well...
Abstract Nucleoside configuration (α‐ d vs. β‐ ), nucleobase substituents, and the helical DNA environment of silver‐mediated 5‐aza‐7‐deazaguanine‐cytosine base pairs have a strong impact on stability. This has been demonstrated by investigations oligonucleotide duplexes with α‐ anomeric 5‐aza‐7‐deaza‐2′‐deoxyguanosines 2′‐deoxycytidines incorporated in 12‐mer duplexes. To this end, new synthetic protocol developed to access pure anomers 5‐aza‐7‐deaza‐2′‐deoxyguanosine glycosylation either...
Silver-mediated α-dC-Ag+ -β-dC hybrid base pairs decorated with 5-iodo- or 5-octadiynyl residues are well accommodated in duplex DNA. A strong Tm increase and favorable thermodynamic data for DNA were observed after addition of silver ions. The phenomenon is particularly obvious when both nucleobases the functionalized. Neither position pair, nor type 5-substituent had a negative influence. On contrary, functionalization conventional silver-mediated β-dC-Ag+ homo showed impact induced by...
Abstract A novel tylophorine analog W-8 enhanced Foxp3 expression through both transcriptional and epigenetic programs, its ameliorated TNBS induced colitis. Tylophorine analogs are phenanthroindolizidine alkaloids, several of which have been reported to anticancer, antiviral, anti-inflammatory properties. However, their function in the immune system remains widely unknown. Transcription factor is critical for development Treg, down-regulates maintains tolerance self-antigens. In present...
Abstract Structurally modified nucleosides are central players in the field of nucleic acid chemistry. Adenine–thymine (AT) pyrimido[4,5‐d]pyrimidine furanosyl and pyranosyl arabinonucleosides have been synthesized for first time. Single‐crystal X‐ray diffraction analysis reveals novel base pairs that, synergy with sugar residues, direct emergence distinct networks containing channels cavities. The microscopic noncovalent connections can be translated into macroscopic levels which robust...
The title compound, 3-amino-4-morpholino- N-[2-(trifuoromethoxy)phenyl]-1 H-indazole-1-carboxamide has been synthesised by condensation of 1-isocyanato-2-(trifluoromethoxy)benzene with 4-morpholino-1 H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile amination morpholine and then cyclisation hydrazine hydrate. crystal the compound belongs to monoclinic system, space group P2 1 /n a = 11.0292(7) Å, b 11.4332(8) c 15.6690(8) α 90°, β 102.481(6)°, γ 90°. In addition, possesses...