A5101957490- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- Gut microbiota and health
- Hepatitis C virus research
- IL-33, ST2, and ILC Pathways
- Viral gastroenteritis research and epidemiology
- Phagocytosis and Immune Regulation
- Drug-Induced Hepatotoxicity and Protection
- Inflammasome and immune disorders
- Pediatric health and respiratory diseases
- Liver physiology and pathology
- Cancer-related molecular mechanisms research
- Endoplasmic Reticulum Stress and Disease
- Virus-based gene therapy research
- Eosinophilic Esophagitis
- Reproductive System and Pregnancy
University of Science and Technology of China
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking University
2024
Hefei National Center for Physical Sciences at Nanoscale
2007-2023
Ruijin Hospital
2020-2023
Shanghai Jiao Tong University
2020-2023
Hainan Medical University
2021
Henan Normal University
2020
Chinese Academy of Sciences
2015-2017
Zhejiang University
2017
The microbiota control regional immunity using mechanisms such as inducing IL-17A-producing γδ T (γδT-17) cells in various tissues. However, little is known regarding hepatic γδT that are constantly stimulated by gut commensal microbes. Here we show liver-resident and predominant producers of IL-17A. sustain γδT-17 cell homeostasis, including activation, survival proliferation. global quantity affects the number cells; indeed, E. coli alone can generate a dose-dependent manner....
Abstract Hepatitis B virus (HBV) persistence is a fundamental process in chronic HBV infection and key factor all related liver diseases; however, the mechanisms have yet to be elucidated. We studied role of TLR2 using well-established HBV-carrier mouse model generated by hydrodynamically injecting phospho–adeno-associated virus/HBV1.2 plasmid into mice. found that genetic deficiency improves elimination, whereas activating led more stable persistence, suggesting activation critical...
Abstract The mechanisms of liver hepatitis B virus (HBV)–induced systemic immune tolerance are still elusive, and the role γδT cells has not yet been described. We examined function in HBV-carrier mice––immunocompetent mice with plasmid-mediated persistent HBV expression liver. In this study, we found that cell deficiency led to a break HBV-induced subsequent recovery hepatic HBV-specific CD8+ T cells. Of interest, IL-17−/− phenocopied TCRδ−/− terms losing persistence, adoptive transfer...
The innate immunopathogenesis responsible for the susceptibility to hepatocyte injury in chronic hepatitis B surface antigen carriers is not well defined. In this study, virus (HBV) transgenic mice (named HBs-Tg) were oversensitive liver after immunologic [polyinosinic:polycytidylic acid or concanavalin A (ConA)] chemical (CCl4) triggering. It was then found that nonhepatotoxic low dose of ConA wild-type induced severe HBs-Tg mice, which dependent on accumulated intraheptic natural killer...
Abstract Purpose: Non–small cell lung carcinoma (NSCLC) is one of most common malignant diseases and usually resistant against apoptosis-inducing chemotherapy. This study to explore the antiapoptotic mechanisms interleukin (IL)-22 in human cancer. Experimental Design: Nineteen cases with stage I III NSCLC were collected determine expression IL-22. Stable transfection IL-22 cDNA into A549 PG cells IL-22-RNA interference (RNAi) these cancer lines done reveal molecular Results: It was found...
Abstract Interleukin (IL)-27, a newly discovered IL-12 family cytokine, is composed of p28 and EBI3. In this study, CD11c-p28 f/f conditional knockout mice were generated to delete specifically in dendritic cells (DCs). We demonstrated that the absence DC-derived p28, these highly susceptible both low higher concentrations concanavalin A (ConA) (5 mg/kg or 10 mg/kg), with extremely early steady high levels interferon-γ (IFN-γ) sera. Neutralizing IFN-γ prevented ConA-induced liver damage...
Overactivation of innate immunity, particularly natural killer (NK) cells, is harmful to liver regeneration; however, the molecular mechanisms that limit NK cell overactivation during regeneration are still elusive. Here we show a coinhibitory receptor, T Ig and ITIM domain (TIGIT), was selectively up-regulated on along with high expression its ligand, poliovirus receptor (PVR/CD155), hepatocytes regeneration. The absence TIGIT impaired in vivo , cells higher NK-derived interferon-gamma...
Hepatitis B virus (HBV) can induce chronic inflammation, cirrhosis, and eventually hepatocellular carcinoma (HCC). Despite evidence suggesting a link between adaptive immunity HBV-related diseases in humans, the immunopathogenic mechanisms involved are seldom described. Here we show that expression of TIGIT, promising immune checkpoint tumor immunotherapy, increases with age on hepatic CD8+ T cells HBsAg-transgenic (HBs-tg) mice whose system is tolerant to HBsAg. TIGIT blockade or deficiency...
Objective Hepatitis B virus (HBV) can integrate into the chromosomes of infected hepatocytes, contributing to production hepatitis surface antigen (HBsAg) and hepatocarcinogenesis. In this study, we aimed explore whether transcriptionally active HBV integration events spread throughout liver tissue in different phases chronic infection, especially patients with HBsAg loss. Design We constructed high-resolution spatial transcriptomes biopsies containing 13 059 spots from 18 infection analyse...
Commensal bacteria have been proposed to play a role in liver repair after partial (67%) hepatectomy. However, the underlying immune mechanisms remain elusive. Here, we show that regeneration was impaired antibiotic (Atb) water‐treated mice and this impairment strongly correlated with commensal bacterial load. Among various Atbs used our cocktail, ampicillin‐sensitive associated normal regeneration. The number of CD1d‐dependent natural killer T (NKT) cells Atb‐treated hepatectomized markedly...
Abstract Immune mechanisms underlying hepatocellular carcinoma (HCC) are not well understood. Here, we show that the Toll-like receptor TLR2 inhibits production of proinflammatory cytokine IL18 and protects mice from DEN-induced liver carcinogenesis. On this protocol, Tlr2−/− exhibited more aggressive HCC development associated with impaired CD8+ T-cell function. Furthermore, Ly6ChighIL18Rα+ myeloid-derived suppressor cells (MDSC) were increased in number livers before tumor onset. MDSC...
Abstract Although NK cells are classified as innate immune cells, recent studies have demonstrated the transformation of into long-lived memory that contribute to secondary responses in certain mouse models. However, whether mount an Ag-specific response acute influenza virus infection has not yet been examined. Here, we show that, consistent with previous studies, lung play important role controlling viral proliferation after primary infection. although display a phenotype at late stage...
Hepatitis B virus (HBV) is a major risk factor for development of hepatocellular carcinoma (HCC), at least partially due to dysfunctional anti-HBV adaptive immunity; however, the role innate immune response HBV in this process not well understood. In study, low-dose polyinosinic:polycytidylic acid (poly [I:C]), natural killer (NK) cell activator (3 μg/g body weight, twice/week 8 weeks), induced HCC transgenic (HBs-Tg) mice, with an incidence 100% after 6 months, while HBs-Tg mice without...
The effects of the oral administration Rehmannia glutinosa polysaccharide (RGP-1) on immunoregulatory properties, antioxidant activity and resistance against Aeromonas hydrophila in Cyprinus carpio L. were investigated. purified RGP-1 (250, 500 1000 μg/mL) was co-cultured with head kidney cells common carp. proliferation phagocytosis activities cells, concentration nitric oxide (NO) cytokines culture medium determined. Next, 300 carps (47.66 ± 0.43 g) randomly divided into five groups; two...
Since the first report of coronavirus disease (COVID-19) in late December 2019, pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has now widely spread to more than 187 countries and regions. However, it is unclear whether there been cryptic transmission before these early officially confirmed cases, we therefore retrospectively screened for SARS-CoV-2 RNA 1271 nasopharyngeal swab samples, as well prevalence IgM, IgG, total antibodies against 357 matched serum samples...
Background and Aims: Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic under inflammation, play crucial role in liver fibrosis progression. The spleen serves as an extra monocyte reservoir inflammatory conditions; however, the precise mechanisms involvement pathogenesis remain unclear. Approach Results: By splenectomy splenocyte transfusion, it was observed that splenic CD11b + cells accumulated intrahepatically Ly6C lo MoMFs to exacerbate CCl 4 ‐induced fibrosis....