A5016044318- Immune Cell Function and Interaction
- Pregnancy and preeclampsia studies
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Advanced Cellulose Research Studies
- Cancer, Lipids, and Metabolism
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Tryptophan and brain disorders
- Estrogen and related hormone effects
- Lipoproteins and Cardiovascular Health
- Endometriosis Research and Treatment
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- biodegradable polymer synthesis and properties
- Polysaccharides and Plant Cell Walls
- Melanoma and MAPK Pathways
- Circular RNAs in diseases
- Genetics and Neurodevelopmental Disorders
Anhui Medical University
2020-2025
First Affiliated Hospital of Anhui Medical University
2020-2025
University of Science and Technology of China
2018-2024
First Affiliated Hospital of Xi'an Jiaotong University
2011-2024
Qingdao University of Science and Technology
2022-2023
Chinese Academy of Sciences
2022
University of Chinese Academy of Sciences
2022
Institute of Applied Ecology
2022
Beijing University of Chemical Technology
2022
Southern Medical University
2016-2021
Hepatitis B virus (HBV) can induce chronic inflammation, cirrhosis, and eventually hepatocellular carcinoma (HCC). Despite evidence suggesting a link between adaptive immunity HBV-related diseases in humans, the immunopathogenic mechanisms involved are seldom described. Here we show that expression of TIGIT, promising immune checkpoint tumor immunotherapy, increases with age on hepatic CD8+ T cells HBsAg-transgenic (HBs-tg) mice whose system is tolerant to HBsAg. TIGIT blockade or deficiency...
MicroRNAs (miRNAs/miRs) are non-coding RNAs that post-transcriptionally control target genes, and involved in tumorigenesis, apoptosis, proliferation, invasion, metastasis chemoresistance. However, data concerning miRNAs ovarian cancer remain incomplete. The present study aimed to identify affected the malignant phenotype of cancer, analyze their potential mechanisms. demonstrated miR-205 promoted cell proliferation invasion cells via suppressing Phosphatase tensin homolog (PTEN)/mothers...
In the realm of computer graphics, ability to learn continuously from non-stationary data streams while adapting new visual patterns and mitigating catastrophic forgetting is paramount importance. Existing approaches often struggle capture represent essential characteristics evolving concepts, hindering their applicability dynamic graphics tasks. this paper, we propose Ancestral Mamba, a novel approach that integrates online prototype learning into selective discriminant space model for...
CD3+CD56+ NKT-like cells play pivotal roles in the anti-tumor immune defense response. However, little is known regarding circulating patients with primary hepatocellular carcinoma (HCC). In present study, we demonstrate that HCC are functionally impaired and anti-PD-1 blockade improves their potency. Circulating NKT were mainly comprised of CD8+ T cells. The frequencies absolute counts comparable between patents compared to healthy donors. production TNF-α IFN-γ as well cytotoxicity. level...
Although the thin endometrium (TE) has been widely recognized as a critical factor in implantation failure, contribution of miRNA–mRNA regulatory network to development disease etiology remains be further elucidated. This study performed an integrative analysis expression profiles and adjacent normal eight patients with intrauterine adhesion construct transcriptomic networks. A total 1,093 differentially expressed genes (DEGs) 72 miRNAs (DEMs) were identified adhesive TE group compared...
The antiviral response of natural killer (NK) cells and CD8+ T is weak in patients with chronic hepatitis B (CHB) infection. However, the specific characteristics these association between NK cell dysfunction not well known. In this study, higher galectin-9 (Gal-9) expression was observed circulating from CHB than healthy controls found to contribute dysfunction. addition, showed obvious overexpressed TIM-3, receptor Gal-9, during active Gal-9+ Gal-9- were sorted cocultured autologous cells....
Thin endometrium (TE) is a significant factor contributing to fertility challenges, and addressing this condition remains central challenge in reproductive medicine. Menstrual blood–derived mesenchymal stem cells (MenSCs) play crucial role tissue repair regeneration, including that of TE. The Wnt signaling pathway, which highly conserved prevalent eukaryotes, essential for cell proliferation, development, functions. MALAT1 implicated various transcriptional molecular functions, proliferation...
Although persistent hepatitis B virus (HBV) infection is associated with natural killer (NK) cell dysfunction, it remains obscure whether HBV viral antigens are responsible for NK dysfunction in patients chronic (CHB) infection. In this study, we found that the percentage of cells expressing inhibitory receptor, NKG2A, was increased CHB patients, and NKG2A blockade restored function. Furthermore, frequency positively correlated number regulatory T (Tregs) production interleukin-10 (IL-10)...
Alcohol consumption has commonly been associated with semen parameters. However, the association between alcohol intake and parameters in primary secondary infertile men remains unclear. In this study, 776 from China were grouped according to intake: abstainers, moderate drinkers (<9 units/week, up approximately 100 g of ethanol) heavy (≥9 units/week). Semen parameters, including volume, sperm concentration, total count, progressive motility normal morphology investigated. other lifestyle...
The ongoing coronavirus disease 2019 (COVID-19) pandemic represents one of the most exigent threats our lifetime to global public health and economy. As part pandemic, from January 10 March 10, 2020, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) began spread in Hefei (Anhui Province, China) with a total 174 confirmed cases COVID-19. During this period, we were able gather critical information on transmission evolution pathogens through genomic surveillance. Particularly,...
Fetal growth restriction (FGR) is a well-known risk factor for cognitive dysfunction, especially learning and memory abilities. However, knowledge about prevention treatment methods of abilities fetal are limit. Here, Morris water maze passive avoidance tests showed zinc supplementation could protect the impairment caused by FGR. As accumulating evidence suggested that insufficiency placental trophoblast cell invasion was closely related to FGR neurodevelopmental dysplasia, we further...
Objectives Single nucleotide polymorphisms (SNPs) in putative microRNA binding sites (miRSNPs) modulate cancer susceptibility via affecting miRNA binding. Here, we sought to investigate the association between miRSNPs and cervical risk. Methods We first genotyped 41 of 37 cancer-related genes 338 patients 334 controls (Study 1), replicated significant associations 502 600 2). tested effects on microRNA-mRNA interaction by luciferase reporter assay. Results Five SNPs displayed notable with...
The aim of this study is to investigate the effect vitamin D (VD) on learning and memory ability fetal growth restriction (FGR) rat expression NMDA receptor in hippocampus. FGR models were established through passive smoking, divided into two groups randomly, i.e. control group observation group. Rats fed regular diet with addition VD serum level 25(OH)-D3 was assayed both rats at different time points using ELISA, aged 30 days evaluated Morris water maze avoidance test. In addition, we also...
I In nt tr ro od du uc ct ti io on n: : Pre-eclampsia (PE) is the most serious syndrome of human pregnancy and it potentially life-threatening for both mother fetus.The aim study was to identify role high temperature requirement A1 (HtrA1) in pre-eclampsia.M Ma at te er ri ia al l a an nd d m me et th ho ds s: One hundred consecutive pregnancies complicated by PE 100 normal controls were included our study.The changes serum HtrA1 fetal growth restriction recorded.The placentae after delivery...