A5071025916- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- GABA and Rice Research
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- RNA Research and Splicing
- Hemoglobinopathies and Related Disorders
- Cancer-related gene regulation
- Biochemical Analysis and Sensing Techniques
- Bipolar Disorder and Treatment
- Influenza Virus Research Studies
- Genetic Syndromes and Imprinting
- Autism Spectrum Disorder Research
- Birth, Development, and Health
- RNA and protein synthesis mechanisms
- Design Education and Practice
- Manufacturing Process and Optimization
- Liver Disease Diagnosis and Treatment
- Nicotinic Acetylcholine Receptors Study
- Respiratory viral infections research
- Plant nutrient uptake and metabolism
- Biochemical effects in animals
Southern Medical University
2016-2025
Guangdong Provincial People's Hospital
2023-2025
University of California, Irvine
1996-2024
Key Laboratory of Guangdong Province
2016-2024
Guangdong Academy of Medical Sciences
2023
Zhujiang Hospital
2022
China Guangzhou Analysis and Testing Center
2021
Cell Technology (China)
2019
GTx (United States)
2019
University of Hong Kong
2006-2016
Major depressive disorder is a common and devastating psychiatric disease, the prevalence burden are substantially increasing worldwide. Multiple studies of depression patients have implicated glucose metabolic dysfunction in pathophysiology depression. However, molecular mechanisms by which related pathways modulate depressive-like behaviors largely uncharacterized. Uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) metabolite with pivotal functions as donor molecule for O-GlcNAcylation....
The irrational use of nitrogen (N) fertilizer has become a major threat to soil quality and food security, resulting in serious ecological environmental problems. Holistic approaches N application are required maintain high utilization efficiency (NUE) sustainable agriculture development. Biochar is an efficient carbon-rich material for amending promoting crop uptake, but knowledge pertaining the effects biochar on fertilizers still limited. In this study, field plot experiment was designed...
Schizophrenia is a polygenetic disease, the heterogeneity of which likely complicated by epigenetic modifications yet to be elucidated. Here, we performed transcriptomic analysis peripheral blood RNA from monozygotic twins discordant for schizophrenia and identified schizophrenia-associated down-regulated microRNA, miR-501-3p. We showed that loss miR-501-3p in germline knockout (KO) male mice resulted dendritic structure defects, glutamatergic transmission enhancement, sociability, memory,...
Maternal antenatal corticosteroid treatment is standard care to accelerate fetal maturation. However, there are growing concerns that administration may harm neurodevelopment. Quantitative assessments of the effects on neonates have not been performed and poorly understood about their complex biology. We collected Methylation BeadChips-generated DNA methylation data from Gene Expression Omnibus (GEO) database then employed "multi-tissue predictor" quantify DNAm age saliva 36 preterm...
Abstract Schizophrenia is a serious neuropsychiatric disorder with abnormal age-related neurodevelopmental (or neurodegenerative) trajectories. Although an accelerated aging hypothesis of schizophrenia has been proposed, the quantitative study disruption physiological trajectory caused by inconclusive. In this study, we employed 3 “epigenetic clock” methods to quantify epigenetic age large sample size whole blood (1069 samples from patients vs 1264 unaffected controls) and brain tissues (500...
Background Non-coding single nucleotide polymorphisms (SNPs) in GABRB2, the gene for β2-subunit of gamma-aminobutyric acid type A (GABAA) receptor, have been associated with schizophrenia (SCZ) and quantitatively correlated to mRNA expression alternative splicing. Methods Findings Expression Exon 10 region GABRB2 from minigene constructs revealed this be an “alternative splicing hotspot” that readily gave rise differently spliced isoforms depending on intron sequences. This led a search...
The SCZ (schizophrenia)-associated GABAA receptor (γ-aminobutyric acid type A receptor) β2 subunit gene GABRB2 was recently associated with BPD (bipolar disorder). Although weaker than its association SCZ, significant of found in both German and Chinese, especially for the haplotypes rs1816071–rs187269 rs1816072–rs187269 which M–M variants showed higher frequency disease control. Significant genotype-dependent reduction expression shown BPD, but to a lesser extent that SCZ. Temporal effects...
The occurrence of positive selection in schizophrenia-associated GABRB2 suggests a broader impact the gene product on population fitness. present study considered possibility cognition-related involvement by examining association with psychosis and altruism, respectively representing psychiatric psychological facets social cognition. Four single nucleotide polymorphisms (SNPs) were genotyped for quantitative trait analyses population-based studies. Psychosis was measured either Positive...
Single nucleotide polymorphisms (SNPs) in the human type A gamma-aminobutyric acid (GABA) receptor β2 subunit gene (GABRB2) have been associated with schizophrenia and quantitatively correlated mRNA expression postmortem brain tissue of patients schizophrenia. l-Methionine (MET) administration has reported to cause a recrudescence psychotic symptoms schizophrenia, similar generated MET-induced mice. In this study, zebrafish animal model was used evaluate relationship between gabrb2 its...
The gamma-aminobutyric acid type-A (GABA(A)) receptor plays a major role in inhibitory neurotransmissions. Intronic SNPs and haplotypes GABRB2, the gene for GABA(A) beta(2) subunit, are associated with schizophrenia correlated expression of two alternatively spliced isoforms. In present study, using chimpanzee as an ancestral reference, high frequencies were observed derived (D) alleles four rs6556547, rs187269, rs1816071 rs1816072 suggesting occurrence positive selection these alleles....
Background Schizophrenia is a major disorder with complex genetic mechanisms. Earlier, population studies revealed the occurrence of strong positive selection in GABRB2 gene encoding β2 subunit GABAA receptors, within segment 3,551 bp harboring twenty-nine single nucleotide polymorphisms (SNPs) and containing schizophrenia-associated SNPs haplotypes. Methodology/Principal Findings In present study, possible recombination this ‘S1–S29’ was assessed. The hotspot indicated by high resolution...