A5101408340- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Birth, Development, and Health
- Stress Responses and Cortisol
- Advancements in Transdermal Drug Delivery
- Regulation of Appetite and Obesity
- Berberine and alkaloids research
- Adipokines, Inflammation, and Metabolic Diseases
- Alkaloids: synthesis and pharmacology
- Ginseng Biological Effects and Applications
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Dermatology and Skin Diseases
- Cardiovascular Health and Risk Factors
- Receptor Mechanisms and Signaling
- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
- Anesthesia and Neurotoxicity Research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Neuroendocrine regulation and behavior
- Cancer Immunotherapy and Biomarkers
- Advanced Drug Delivery Systems
- Cancer, Stress, Anesthesia, and Immune Response
- Gastrointestinal disorders and treatments
- Heart Rate Variability and Autonomic Control
- Pregnancy and preeclampsia studies
Zhongda Hospital Southeast University
2025
Shanxi University
2025
Southern Medical University
2021-2024
University of Hong Kong
2021-2024
Weifang University
2024
University of Iowa
2009-2022
Hubei University
2022
Obstetrics and Gynecology Hospital of Fudan University
2021
Xi'an Jiaotong University
2021
Guangzhou Medical University
2011-2020
Major depressive disorder is a common and devastating psychiatric disease, the prevalence burden are substantially increasing worldwide. Multiple studies of depression patients have implicated glucose metabolic dysfunction in pathophysiology depression. However, molecular mechanisms by which related pathways modulate depressive-like behaviors largely uncharacterized. Uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) metabolite with pivotal functions as donor molecule for O-GlcNAcylation....
Nitroreductases (NRs) are bacterial enzymes that reduce nitro-containing compounds.We have previously reported NR of intestinal bacteria is a key factor promoting berberine (BBR) absorption.We show here feeding hamsters with high fat diet (HFD) caused an increase in blood lipids and activity the intestine.The elevation fecal by HFD was due to either fraction NR-producing or their intestine.When given orally, BBR bioavailability HFD-fed higher than those fed normal chow (by +72%, *P<0.05).BBR...
Obesity is characterized by increased circulating levels of the adipocyte-derived hormone leptin, which can increase sympathetic nerve activity and raise blood pressure. A previous study revealed that rats fed a high-fat diet (HFD) have an enhanced hypertensive response to subsequent angiotensin II administration mediated at least, in part, brain renin-angiotensin system proinflammatory cytokines. This tested whether leptin mediates this HFD-induced sensitization II-elicited hypertension...
Abstract Epigenetic mechanisms bridge genetic and environmental factors that contribute to the pathogenesis of major depression disorder (MDD). However, cellular specificity sensitivity stress on brain epitranscriptomics its impact remain unclear. Here, we found ALKBH5, an RNA demethylase N6-methyladenosine (m6A), was increased in MDD patients’ blood models. ALKBH5 astrocytes more sensitive than neurons endothelial cells. Selective deletion astrocytes, but not cells, produced...
Many studies have implicated both angiotensin II (ANG II) and aldosterone (Aldo) in the pathogenesis of hypertension, progression renal injury, cardiac remodeling after myocardial infarction. In several cases, ANG Aldo been shown to synergistic interactions periphery. present studies, we tested hypothesis that interact centrally Aldo- II-induced hypertension male rats. rats with blood pressure (BP) heart rate (HR) measured by DSI telemetry, intracerebroventricular (icv) infusions...
Berberine (BBR), as a new medicine for hyperlipidemia, can reduce the blood lipids in patients. Mechanistic studies have shown that BBR activates extracellular-signal regulated kinase pathway by stabilizing low-density-lipoprotein receptor mRNA. However, aside from inhibiting intestinal absorption of cholesterol, effects on other metabolic pathways cholesterol not been reported. This study aimed to investigate action excretion high-fat diet-induced hyperlipidemic hamsters. Golden hamsters...
Obesity has been shown to promote renin–angiotensin system activity and inflammation in the brain be accompanied by increased sympathetic blood pressure. Our previous studies demonstrated that administration of a subpressor dose angiotensin (Ang) II sensitizes subsequent Ang II–elicited hypertension. The present study tested whether high-fat diet (HFD) feeding also hypertensive response HFD-induced sensitization is mediated an increase inflammatory mechanisms brain. HFD did not baseline...
Berberine (BBR) is considered a multi-target drug that has significant advantages. In contrast to its pharmacological effects in clinic, the plasma level of BBR very low. Our previous work revealed dihydroberberine (dhBBR) could be an absorbable form intestine, and butyrate active metabolite generated by gut bacteria rats. this study, for first time we describe microbiota-regulated pharmacokinetics beagle dogs after oral administration single (50 mg/kg) or multiple doses mg/kg/d) 7 days....
Short-term exposure to fine particulate matter (PM2.5) and its specific constituents might exacerbate allergic rhinitis (AR) conditions. However, the evidence is still inconclusive.We conducted a panel study of 49 patients diagnosed with AR > 1 year prior in Taiyuan, China, investigate associations individual PM2.5 oxidative parameters, symptoms, quality life among patients. All participants underwent repeated assessments health PM at 4 time points both heating nonheating seasons from June...
Abstract Under long-standing threat of seasonal influenza outbreaks, it remains imperative to understand the drivers dynamics which can guide mitigation measures. While role absolute humidity and temperature is extensively studied, possibility ambient ozone (O 3 ) as an environmental driver has received scant attention. Here, using state-level data in USA during 2010–2015, we examined such research hypothesis. For rigorous causal inference by evidence triangulation, applied distinct methods...
Background The programmed cell death 1 (PD-1) is an immune checkpoint that mediates evasion of tumors. Alternative splicing (AS) such as intron retention (IR) plays a crucial role in the immune-related gene processing and its function. However, it not clear whether PDCD1 encoding PD-1 exists IR isoform what underlying function tumor evasion. Methods An AS human , characterized by second named IR2 was identified reverse transcription-PCR (RT-PCR) Sanger sequencing. expression profile PD1...
The present study tested the hypotheses that male and female rats respond differently to subcutaneous infusions of aldosterone (Aldo; 1.8 μg·kg −1 ·h , 1% NaCl drink; 28 days) central estrogen plays a protective role against development hypertension. In with blood pressure (BP) heart rate (HR) measured by Data Sciences International telemetry, chronic Aldo/NaCl treatment induced greater increase in BP males (Δ25.4 ± 2.4 mmHg) than females (Δ7.1 2.2 mmHg). Gonadectomy augmented...
Key points Central hypercapnic hypoventilation is highly prevalent in children suffering from congenital central syndrome (CCHS). Mutations of the gene for paired‐like homeobox 2b (Phox2b) are aetiologically associated with CCHS and Phox2b present components respiratory chemoreflex, such as nucleus tractus solitarius (NTS). Injection neurotoxin substance P‐saporin into NTS destroys Phox2b‐expressing neurons. Impaired ventilatory response caused by this attributable to a loss CO 2 ‐sensitive...
The present study tested the hypotheses that 1) nitric oxide (NO) is involved in attenuated responses to ANG II female mice, and 2) there differential expression of neuronal NO synthase (nNOS) subfornical organ (SFO) paraventricular nucleus (PVN) response systemic infusions males vs. females. Aortic blood pressure (BP) was measured conscious mice with telemetry implants. N(G)-nitro-l-arginine methyl ester (l-NAME; 100 microg x kg(.-1)day(-1)), an inhibitor NOS, administrated into lateral...
Mineralocorticoid excess increases superoxide production by activating NADPH oxidase (NOX), and intracerebroventricular infusions of inhibitors attenuate aldosterone (Aldo)/salt-induced hypertension. It has been hypothesized that increased reactive oxygen species (ROS) in the brain may be a key mechanism development The present study investigated regional specificity role NOX2 NOX4 subunits hypothalamic paraventricular nucleus (PVN) Aldo/salt-induced PVN injections adenoviral vectors...
Inflammation and renin–angiotensin system activity in the brain contribute to hypertension through effects on fluid intake, vasopressin release, sympathetic nerve activity. We recently reported that activation of peroxisome proliferator–activated receptor (PPAR)-γ heart failure rats reduced inflammation hypothalamic paraventricular nucleus ameliorated peripheral manifestations failure. hypothesized PPAR-γ might have beneficial angiotensin II–induced hypertension. Sprague–Dawley received a...
In comparison to male rodents, females are protected against angiotensin (ANG) II- and aldosterone (Aldo)-induced hypertension. However, the mechanisms underlying this protective effect not well understood. ANG-(1-7) is formed from ANG II by angiotensin-converting enzyme 2 (ACE2) has an antihypertensive in central nervous system (CNS). The present study tested hypothesis that plays important role attenuating development of Aldo/NaCl-hypertension female rats. Systemic infusion Aldo into...
Anxiety disorders are debilitating psychiatric diseases that affect ∼16% of the world's population. Although it has been proposed central nucleus amygdala (CeA) plays a role in anxiety, molecular and circuit mechanisms through which CeA neurons modulate anxiety-related behaviors largely uncharacterized. Soluble epoxide hydrolase (sEH) is key enzyme metabolism polyunsaturated fatty acids (PUFAs), shown to play disorders. Here, we reported sEH was enriched regulated adult male mice. Deletion...
Abstract Lysosomes are important cellular structures for human health as centers recycling, signaling, metabolism and stress adaptation. However, the potential role of lysosomes in stress‐related emotions has long been overlooked. Here, it is found that lysosomal morphology astrocytes altered medial prefrontal cortex (mPFC) susceptible mice after chronic social defeat stress. A screen lysosome‐related genes revealed expression mucolipin 1 gene ( Mcoln1 ; protein: TRP channel 1) decreased...