A5055756006- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Regulation of Appetite and Obesity
- Heart Rate Variability and Autonomic Control
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Electrolyte and hormonal disorders
- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Neuropeptides and Animal Physiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Sodium Intake and Health
- Diet and metabolism studies
- Apelin-related biomedical research
- Neuroscience and Neuropharmacology Research
- Thermoregulation and physiological responses
- Circadian rhythm and melatonin
- Biochemical Analysis and Sensing Techniques
- Cardiac Health and Mental Health
- Estrogen and related hormone effects
- Sleep and Wakefulness Research
University of Iowa
2016-2025
Fraternal Order of Eagles
2025
Northwell Health
2023-2024
Long Island Jewish Medical Center
2024
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2024
University of Notre Dame
2023
Tongji University
2017
Hebei North University
2017
Second Affiliated Hospital of Zhejiang University
2017
Public Health England
2016
The connections of the subfornical organ (SFO) were investigated by using HRP technique. Injections into SFO labeled neurons in medial septum, but not lateral septum nor diagonal band nucleus. Labeled cells observed median preoptic nucleus, below ependyma third ventricle, dorsal region near anterior commissure, and diffusely throughout hypothalamic areas. Fibers followed from ventral stalk SFO. Precommissural fibers enter nucleus where many them appear to terminate. Others continue on OVLT,...
To determine whether: a) plasma osmolarity (Posm) is sensitive to small incremental changes in hydration status, b) urine specific gravity (Usg) can accurately identify a state of euhydration, c) Usg indicator change and d) correlates with Posm.Euhydrated (Posm = 288 +/- 4 mOsm.L-1) subjects (N 12) were dehydrated by 5% their body weight via exercise the heat (40 degrees C, 20% RH). Posm, (Uosm), measured at 1%, 3%, dehydration, 30 60 min recovery (rec). Subjects consumed water equal loss...
Depressed patients with and without a history of cardiovascular pathology display signs, such as elevated heart rate, decreased rate variability, increased physiological reactivity to environmental stressors, which may indicate predisposition disease. The specific mechanisms associating depression altered parameters are presently unclear. current study investigated regulation in the chronic mild stress rodent model examined autonomic nervous system underlying responses. Sprague-Dawley rats...
This study compares the effect of arginine-vasopressin with phenylephrine on arterial pressure, heart rate, and renal sympathetic nerve activity in conscious rabbits without functional baroreflexes lesions area postrema. In intact rabbits, progressive infusions result large decreases rate for a given increase blood pressure as compared to phenylephrine. sinoaortic-denervated responses both are markedly attenuated, indicating necessity afferent baroreceptor this response. observation...
Obesity is characterized by increased circulating levels of the adipocyte-derived hormone leptin, which can increase sympathetic nerve activity and raise blood pressure. A previous study revealed that rats fed a high-fat diet (HFD) have an enhanced hypertensive response to subsequent angiotensin II administration mediated at least, in part, brain renin-angiotensin system proinflammatory cytokines. This tested whether leptin mediates this HFD-induced sensitization II-elicited hypertension...
This study examined the early neurohumoral events in progression of congestive heart failure (CHF) after myocardial infarction (MI) rats. Immediately MI was induced by coronary artery ligation, rats had severely depressed left ventricular systolic function and increased end-diastolic volume (LVEDV). Both indicators CHF underwent dynamic changes over next 6 wk. LVEDV continuously interval, whereas stroke but reached a plateau at 4 Plasma renin activity (PRA), arginine vasopressin, atrial...
SUMMARY 1. Cardiovascular and body fluid homeostasis depends upon the activation co‐ordination of reflexes behavioural responses. In order to accomplish this, brain receives processes both neural chemical input. Once in brain, information from sources signalling status cardiovascular system balance travels, is integrated, throughout a widely distributed network. Recent studies using neuroanatomical functional techniques have identified several key areas within this One major processing node...
The inflammatory milieu of acute myocardial infarction (MI) is theoretically conducive to enhanced cytokine synthesis within the brain. We tested hypothesis that tumor necrosis factor-alpha (TNF-alpha), an indicator proinflammatory activity, increases in brain after MI. MI was induced rats by ligating left anterior descending coronary artery and confirmed echocardiography. Plasma tissue levels TNF-alpha were measured using ELISA; mRNA with real-time PCR. Heart, brain, plasma samples obtained...
Abstract —We have previously shown that mice transgenic for both the human renin and angiotensinogen genes (RA+) exhibit appropriate tissue- cell-specific expression of transgenes, 4-fold higher plasma angiotensin II (AII) levels, are chronically hypertensive. However, relative contribution circulating tissue-derived AII in causing hypertension these animals is not known. We hypothesized brain renin-angiotensin system contributes to elevated blood pressure this model. To address hypothesis,...
This study investigated the effects of bilateral injections serotonergic receptor agonist and antagonist into lateral parabrachial nucleus (LPBN) on ingestion water 0.3 M NaCl induced by intracerebroventricular angiotensin II (ANG II) or combined subcutaneous diuretic furosemide (Furo) angiotensin-converting enzyme inhibitor captopril (Cap). Rats had stainless steel cannulas implanted bilaterally LPBN left ventricle. Bilateral pretreatment with 5-HT1/5-HT2 methysergide (4 micrograms/200 nl...
Blocking brain mineralocorticoid receptors (MRs) reduces the high circulating levels of tumor necrosis factor (TNF)-α in heart failure (HF) rats. TNF-α and other proinflammatory cytokines activate neurons paraventricular nucleus (PVN) hypothalamus, including corticotropin-releasing hormone (CRH) neurons, by inducing cyclooxygenase (COX)-2 activity synthesis prostaglandin E 2 perivascular cells cerebral vasculature. We tested hypothesis that systemic treatment with a MR antagonist would...
The mineralocorticoid (MC) receptor antagonist spironolactone (SL) improves morbidity and mortality in patients with congestive heart failure (CHF). We tested the hypothesis that central nervous system actions of SL contribute to its beneficial effects. (100 ng/h for 28 days) or ethanol vehicle (VEH) was administered intracerebroventricularly intraperitoneally rats CHF induced by coronary artery ligation (CL) SHAM-operated controls. intracerebroventricular treatment prevented increase sodium...