A5101459243- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Cancer Mechanisms and Therapy
- Gallbladder and Bile Duct Disorders
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Metastasis and carcinoma case studies
- RNA Research and Splicing
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Esophageal and GI Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Circular RNAs in diseases
- CAR-T cell therapy research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
- Chronic Lymphocytic Leukemia Research
- Enhanced Recovery After Surgery
- MicroRNA in disease regulation
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Oral and gingival health research
Zhongda Hospital Southeast University
2021-2025
Affiliated Hospital of North Sichuan Medical College
2019-2023
Second Military Medical University
2023
Eastern Hepatobiliary Surgery Hospital
2023
North Sichuan Medical University
2019
China Pharmaceutical University
2018
Background The programmed cell death 1 (PD-1) is an immune checkpoint that mediates evasion of tumors. Alternative splicing (AS) such as intron retention (IR) plays a crucial role in the immune-related gene processing and its function. However, it not clear whether PDCD1 encoding PD-1 exists IR isoform what underlying function tumor evasion. Methods An AS human , characterized by second named IR2 was identified reverse transcription-PCR (RT-PCR) Sanger sequencing. expression profile PD1...
Overexpression of Ras, in addition to the oncogenic mutations, occurs various human cancers. However, mechanisms for epitranscriptic regulation RAS tumorigenesis remain unclear. Here, we report that widespread N 6 -methyladenosine (m A) modification HRAS , but not KRAS and NRAS is higher cancer tissues compared with adjacent tissues, which results increased expression H-Ras protein, thus promoting cell proliferation metastasis. Mechanistically, three m A sites 3′ UTR, regulated by FTO bound...
Summary Background Immune checkpoint inhibitor (ICI) combination therapy offers a new option for treatment of unresectable intrahepatic cholangiocarcinoma (uICC). Aim To compare the effect different anti‐PD‐1 therapies as first‐line treatments uICC. Methods This study included 318 patients who received chemotherapy alone (Chemo), plus (ICI‐chemo), targeted (ICI‐target) or and (ICI‐target‐chemo) first line uICC from 22 centres in China. The primary endpoint was progression‐free survival...
Abstract Background and Aims Sarcopenia is associated with poor prognosis, but its role in older patients intrahepatic cholangiocarcinoma (ICC) unclear. We aimed to evaluate the impact of sarcopenia on prognosis ICC undergoing hepatectomy. Methods A total 363 following hepatectomy from 2015 2021 were retrospectively reviewed at five institutions. was evaluated using skeletal muscle index by computed tomography images. Patients divided into four subgroups according age. Postoperative outcomes...
Background: Gallbladder cancer (GBC) is the most common of biliary tract, but molecularly targeted therapies are not available for GBC. Loss microRNA (miR)-335 expression may be a useful predictor clinical outcomes and reversal its loss treatment strategy In this study, we investigated whether long noncoding RNA, nuclear paraspeckle assembly transcript 1 ( NEAT1 ) sponges miR-335 in GBC cells. Materials Methods: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR), Western...
Abstract Immunotherapy, including ICIs, has emerged as an invaluable treatment option for advanced PLC. Nevertheless, the expression patterns of PD‐L1 and PD‐1 in PLC remain incompletely understood. In this study, pattern clinical correlation were analysed 5245 patients. The positivity rates very low patient PLCs, but higher ICC cHCC‐ICC than HCC. correlated with malignant phenotypes clinicopathological characteristics Interestingly, might serve independent prognostic factor. Based on a...
The aim of this study was to explore the clinical value lymph node dissection (LND) for intrahepatic cholangiocarcinoma (ICC).Clinical and pathological data were collected from 147 ICC patients who attended two tertiary centers over past 5 years. classified into groups: LND group (group A) no-performance (NLND) B). Clinical parameters compared between groups analyze impact on long-term survival time patients.Of patients, 54.4% (80) received 42.5% (34/80) these found have metastasis (LNM)....
Index cholecystectomy is insufficient for curing T3 incidental gallbladder cancer (IGC), and once residual (RC) found, the prognosis often poor. The purpose of this study was to investigate effect RC on optimal choice adjuvant therapy R0 reresection patients with IGC.We retrospectively reviewed data from IGC who underwent radical January 2013 December 2018. defined as histologically proven at reresection. Demographics tumour treatment-related variables were analysed in correlation survival....
Objective: To compare the efficacy of modified pancreaticojejunostomy with traditional following pancreaticoduodenectomy, and to investigate risk factors postoperative pancreatic fistula. Methods: Clinical data 68 patients who underwent pancreaticoduodenectomy between October 2017 2018 at Second Department Biliary Tract Surgery, Eastern Hepatobiliary Surgery Hospital was retrospectively collected analyzed.According method pancreaticojejunostomy, were divided into two groups: group (34...
Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver cancer with limited treatment options and poor prognosis. Although gemcitabine combined cisplatin (GEMCIS) or newly GEMCIS plus durvalumab the first-line systemic therapy for iCCA, several promising targets have been identified in past decade both first- subsequent-line settings, including neurotrophic tropomyosin-receptor tyrosine kinase (NTRK) fusions, RET high microsatellite instability (MSI-H), tumor mutation...
Objective: To discuss the rationality of stage pT3 in AJCC 8(th) TNM criteria gallbladder carcinoma. Methods: A retrospective study was performed to analyze clinical and pathological data 88 patients with carcinoma admitted Department Second Biliary Surgery Eastern Hepatobiliary Hospital, affiliated Naval Medical University from May 2013 September 2018.pT3 tumors were divided into two groups: (1) pT3a stage: had penetrated serosa but not directly invaded liver and/or an adjacent organ or...
Objective To investigate the effects of extent regional lymph node dissection on prognosis patients with T4 gallbladder carcinoma. Methods The retrospective cohort study was conducted. The clinicopathological data 64 carcinoma who underwent radical cholecystectomy in 4 medical centers between January 2013 and December 2016 were collected, including 31 Eastern Hepatobiliary Surgery Hospital Naval Medical University, 16 First Affiliated Xi′an Jiaotong 11 Xinhua to Shanghai University...
Abstract Objective: The aim of this study was to explore the clinical value lymph node dissection (LND) for intrahepatic cholangiocarcinoma (ICC). Methods: Clinical and pathological data were collected from 147 ICC patients who attended two tertiary centers over past 5 years. classified into groups: LND group (group A) no-performance (NLND) B). parameters compared between groups analyze impact on prognosis patients. Results: Of patients, 54.4% (80) received 42.5% (34/80) these found have...