A5015990766- Hormonal Regulation and Hypertension
- Neuroendocrine regulation and behavior
- Thyroid Disorders and Treatments
- Renin-Angiotensin System Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Neuroscience of respiration and sleep
- Pain Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Anesthesia and Sedative Agents
- Muscle metabolism and nutrition
- Intensive Care Unit Cognitive Disorders
- Stress Responses and Cortisol
- Heart Rate Variability and Autonomic Control
- Estrogen and related hormone effects
- Birth, Development, and Health
- Family and Patient Care in Intensive Care Units
- Biochemical Analysis and Sensing Techniques
- Eicosanoids and Hypertension Pharmacology
- Exercise and Physiological Responses
- Essential Oils and Antimicrobial Activity
- Biochemical effects in animals
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pharmacological Effects of Natural Compounds
Universidade Federal de Sergipe
2013-2024
University of Iowa
2007-2009
Universidade Federal Rural do Rio de Janeiro
2001-2009
Universidade de São Paulo
2005-2008
Universidade de Ribeirão Preto
2008
Abstract α‐Terpineol ( TPN ), a volatile monoterpene alcohol, is relatively non‐toxic and one of the major components essential oils various plant species. In this study, we tested for antihypernociceptive activity (25, 50 or 100 mg/kg, i.p.) in mice using mechanical models hypernociception induced by carrageenan CG , 300 μg/paw) involvement important mediators its cascade signalling, such as tumour necrosis factor‐α TNF ‐α, pg/paw), prostaglandin E 2 PGE ng/paw) dopamine DA 30 μg/paw). We...
The present study tested the hypotheses that male and female rats respond differently to subcutaneous infusions of aldosterone (Aldo; 1.8 μg·kg −1 ·h , 1% NaCl drink; 28 days) central estrogen plays a protective role against development hypertension. In with blood pressure (BP) heart rate (HR) measured by Data Sciences International telemetry, chronic Aldo/NaCl treatment induced greater increase in BP males (Δ25.4 ± 2.4 mmHg) than females (Δ7.1 2.2 mmHg). Gonadectomy augmented...
Although it is well established that fibromyalgia (FM) syndrome characterized by chronic diffuse musculoskeletal hyperalgesia, very little known about the effect of this pathology on muscle tissue plasticity. Therefore, present study aimed to characterize putative alterations in skeletal mass female rats subjected a FM model inducing hyperalgesia (CDH) through double injections acidic saline (pH 4.0) into left gastrocnemius at 5-day intervals. To determine protein turnover, total...
Abstract Background and Purpose Pain assessment in Intensive Care Units ( ICU ) can be performed based on validated instruments as the Behavioral Scale BPS ). Despite existence of this clinical score, there is no Brazilian version it to assess critically ill patients. This study aimed translate into Portuguese, verify its psychometric properties (reliability, validity, responsiveness) correlation between pain measured heart rate HR ), blood pressure BP Ramsay, RASS scores. Methods intensity...
We investigated the effects of chronic administration sertraline (SERT; ∼20 mg kg −1 day in drinking water), a selective serotonin reuptake inhibitor, on water and sodium intake plasma levels oxytocin (OT) vasopressin (AVP) basal stimulated conditions. Basal was reduced SERT‐treated rats. After 24 h deprivation, rats treated with SERT for 21 days ingested less than control (9.7 ± 0.5 versus 20.0 0.9 ml, respectively, at 300 min after presentation, P < 0.0001). Subcutaneous injection 2 m...
Background. Injections of acidic saline into the gastrocnemius muscle in rats produce a bilateral long-lasting hyperalgesia similar to fibromyalgia humans. No previous study investigated effect electroacupuncture (EA) on this model. This aimed identify effects EA produced by repeated intramuscular injections saline. Methods. Rats were divided four groups (n = 6, each group): control, acupuncture, 15 Hz, and 100 Hz. Left was injected with μ L pH 4.0 sterile twice five days apart. EA, or...
We determined if the dorsal raphe nucleus (DRN) exerts tonic control of basal and stimulated sodium water intake. Male Wistar rats weighing 300-350 g were microinjected with phosphate buffer (PB-DRN, N = 11) or 1 µg/0.2 µl, in a single dose, ibotenic acid (IBO-DRN, 9 to 10) through guide cannula into DRN observed for 21 days order measure appetite intake following situations: furosemide-induced depletion (20 mg/kg, sc, 24 h before experiment) low dose dietary captopril (1 mg/g chow). From...
We investigated the possible role of 5-HT(1A) somatodendritic autoreceptors in dorsal raphe nucleus (DRN) on salt intake response during basal conditions and following natriorexigenic challenge aroused by sodium depletion rats. Acute systemic administration (76-1520 nmol/kg s.c.) 8-OH-DPAT, a selective autoreceptor agonist, induced clear dose-dependent preference for through free choice between water 0.3 M NaCl simultaneously offered under conditions. intra-DRN microinjection (7.5 nmol/rat)...
Background and objectives: The Behavioral Pain Scale is a pain assessment tool for uncommunicative sedated Intensive Care Unit patients.The lack of Brazilian scale in adults mechanically ventilated justifies the relevance this study that aimed to validate version as well correlate its scores with records physiological parameters, sedation level severity disease.Methods: Twenty-five adult patients were included study.The (previously translated culturally adapted) recording parameters...
Abstract Background Thyroid hormones ( THs ) play a crucial role in the development of several organic systems. An adequate support maternal may be required to ensure normal nociceptive function offspring into adulthood. We investigated impact experimental gestational hypothyroidism EGH on threshold and motor performance at different post‐natal days PND both male female rats. Methods was induced by administration 0.02% methimazole MMI drinking water from ninth day gestation until birth. The...
The aim of the present work was to investigate role serotoninergic system in control sodium appetite hypothyroid rats (HTR) by administering drugs that affect activity, and compare same homeostatic behaviour euthyroid (ETR) also given these drugs. Fenfluramine (FEN; 5.0 mg kg −1 , I.P.), which releases serotonin brain, significantly reduced intake 1.8% NaCl HTR subjected water depletion (depleted) or water, food deprivation (deprived) 31 45%, respectively, 120 min after FEN injection,...
The Behavioral Pain Scale is a pain assessment tool for uncommunicative and sedated Intensive Care Unit patients. lack of Brazilian scale in adults mechanically ventilated justifies the relevance this study that aimed to validate version as well correlate its scores with records physiological parameters, sedation level severity disease.Twenty-five adult patients were included study. (previously translated culturally adapted) recording parameters performed by two investigators simultaneously...
We investigated the role of 5-HT2C receptors and serotonergic transmission in feeding behavior control quails. Administration serotonin releaser, fenfluramine (FEN) agonists, mCPP MK212, 1.0 3.3 mg/Kg induced significant inhibition food intake previously fasted fowls (0.71 +/- 0.18 g 0.47 0.2 g; 0.49 0.22 0.48 0.29 0.82 0.13 0.71 0.16 g, respectively). Control groups ranged from 2.89 0.21 to 2.97 60 min after reintroduction food, P < 0.0001). Similar results were obtained with normally fed...
Dehydration, characterized by the loss of total body water and/or electrolytes due to diseases or inadequate fluid intake, is prevalent globally but often underestimated. Its contribution long-term chronic and sarcopenia recognized, yet mechanisms involved in systemic muscle protein metabolism during dehydration remain unclear. This study investigated metabolic adaptations a 36-hour deprivation (WD) model mice. Male C57BL/6 mice underwent 36-h WD pair-feeding at rest, with assessments motor...
The involvement of angiotensin AT1 receptors in sodium appetite was studied hypothyroid rats treated with the II antagonist losartan. Losartan administered chronically by oral route or acutely subcutaneous after water and depletion water, food deprivation. Three days addition losartan to at dose 1.0 mg g −1 , significantly reduced (P < 0.02) their spontaneous intake 1.8% NaCl. Increasing 2.0 4.0 did not reduce NaCl intake; contrast, intensity gradually returned previous levels....