A5021153759- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Insect Pest Control Strategies
- Phytochemistry Medicinal Plant Applications
- Research on Leishmaniasis Studies
- Neuroscience and Neuropharmacology Research
- Phytochemicals and Antioxidant Activities
- Synthesis and biological activity
- Bee Products Chemical Analysis
- Piperaceae Chemical and Biological Studies
- Olfactory and Sensory Function Studies
- Medicinal Plant Extracts Effects
- Chemical synthesis and alkaloids
- Cholinesterase and Neurodegenerative Diseases
- Ginger and Zingiberaceae research
- Bioactive Compounds and Antitumor Agents
- Public Health in Brazil
- Insect and Pesticide Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Trypanosoma species research and implications
- Youth, Drugs, and Violence
Universidade Federal da Paraíba
2016-2025
Universidade Estadual do Piau
2025
Centro Universitário do Maranhão
2024
Universidad de Antioquia
2023
Ordem dos Médicos
2023
Centro Universitário Cesmac
2023
Universidade Federal de Campina Grande
2022
Universidade Federal de Sergipe
2007-2016
Universidade Federal do Piauí
2009-2016
Universidade Federal do Ceará
2016
The objective of the present study was to evaluate antinociceptive effects phytol using chemical and thermal models nociception in mice assess its antioxidant vitro. Phytol administered intraperitoneally (i.p.) at doses 25, 50, 100, 200 mg/kg. In acetic acid-induced writhing test, significantly reduced number contortions compared control group (P < 0.001). formalin amount time spent paw licking both phases (the neurogenic inflammatory phases), this effect being more pronounced second phase...
Abstract Studies have shown that diterpenes anti‐inflammatory and redox‐protective pharmacological activities. The present study aimed to investigate the properties of phytol, a diterpene alcohol, in mouse model acute inflammation, phytol effect on leukocyte recruitment, cytokines levels, oxidative stress. activities were assessed by measuring paw edema induced different inflammatory agents (e.g., λ‐carrageenan, compound 48/80, histamine, serotonin, bradykinin, prostaglandin E 2 [ PGE ]),...
Background Schistosomiasis is a major endemic disease that affects hundreds of millions worldwide. Since the treatment and control this parasitic rely on single drug, praziquantel, it imperative new effective drugs are developed. Here, we report phytol, diterpene alcohol from chlorophyll widely used as food additive in medicinal fields, possesses promising antischistosomal properties vitro mouse model schistosomiasis mansoni. Methods findings In vitro, phytol reduced motor activity worms,...
In the present study were studied antinociceptives properties of monoterpene R-(+)-limonene (LM) in chemical and thermal models nociception mice. The was administered, intraperitoneally (i.p.), at doses 25 50 mg/kg. results showed significant inhibition produced on induced by intraperitoneal acetic-acid second phase subplantar formalin test, but did not manifest a effect hot-plate test. R-(+)-limonene-induced antinociception test insensitive to naloxone (1 mg/kg, s.c.). It also demonstrated...
Linalool oxide is a monoterpene that found in some species of aromatic plants. The effects the inhalation linalool (0.65%, 1.25%, 2.5% and 5.0% w/w) elevated plus-maze light/dark box tests as animal models anxiety were investigated adult male mice compared with reference anxiolytic diazepam (0.5 2.0 mg/kg), administered intraperitoneally. Additionally, inhaled rotarod test. significantly increased number visits to open arms amount time spent there well total entries. In test, led an increase...
The traditional use of essential oils in aromatherapy has offered numerous health benefits. However, few scientific studies have been conducted with these to confirm their therapeutic efficacy. (+)-Limonene is a chemical constituent various bioactive oils. present study reports on the anxiolytic-like effects (+)-limonene an elevated maze model anxiety mice. At concentrations 0.5% and 1.0%, (+)-limonene, administered mice by inhalation, significantly modified all parameters evaluated plus...
Leishmaniasis is a group of infectious-parasitic diseases with high mortality rates, and endemic in many regions the globe. The currently available drugs present serious problems such as toxicity, costs, emergence drug resistance. This has stimulated research into new antileishmania based on natural products their derivatives. β-Ocimene monoterpene found naturally essential oils plant species which presents antileishmanial activity, not yet been evaluated for its potential to inhibit...