A5084711108- Research on Leishmaniasis Studies
- Computational Drug Discovery Methods
- Parasites and Host Interactions
- SARS-CoV-2 and COVID-19 Research
- Pulsars and Gravitational Waves Research
- Insect Pest Control Strategies
- Ethnobotanical and Medicinal Plants Studies
- Oral health in cancer treatment
- COVID-19 Clinical Research Studies
- Polysaccharides and Plant Cell Walls
- Phytochemicals and Antioxidant Activities
- Phytochemistry Medicinal Plant Applications
- Geophysics and Gravity Measurements
- Trypanosoma species research and implications
- Antimicrobial Peptides and Activities
- Diverse Scientific Research Studies
- Parasite Biology and Host Interactions
- Wastewater Treatment and Reuse
- Genetic diversity and population structure
- Helminth infection and control
- Moringa oleifera research and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Ginkgo biloba and Cashew Applications
- Iron Metabolism and Disorders
- Nanoparticles: synthesis and applications
Universidade Federal do Maranhão
2014-2024
Universidade Federal do Piauí
2014-2024
Universidade Federal do Delta do Parnaíba
2021-2024
Centro Universitário Maurício de Nassau
2024
Quanta Computer (China)
2024
Universidade Federal do Amazonas
2022-2023
Universidade Estadual do Piau
2018-2022
California State University, Fullerton
2020-2021
Leishmaniasis is a group of infectious-parasitic diseases with high mortality rates, and endemic in many regions the globe. The currently available drugs present serious problems such as toxicity, costs, emergence drug resistance. This has stimulated research into new antileishmania based on natural products their derivatives. β-Ocimene monoterpene found naturally essential oils plant species which presents antileishmanial activity, not yet been evaluated for its potential to inhibit...
BackgroundTreatment and control of schistosomiasis, one the most insidious serious parasitic diseases, depend almost entirely on a single drug, praziquantel. Since funding for drug development poverty-associated diseases is very limited, repurposing promising strategy. In this study, 73 nonsteroidal anti-inflammatory drugs (NSAIDs) commonly used in medical veterinary fields were evaluated their anti-schistosomal properties.MethodsThe efficacy NSAIDs was first tested against adult Schistosoma...
Schistosomiasis affects million people and its control is widely dependent on a single drug, praziquantel. Computational chemistry has led to the development of new tools that predict molecular properties related pharmacological potential. We conducted theoretical study imizadole alkaloids Pilocarpus microphyllus (Rutaceae) with schistosomicidal properties. The molecules epiisopiloturine, epiisopilosine, isopilosine, pilosine, macaubine were evaluated using theory models (B3lyp/SDD,...
Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU). Rutin (RUT), a natural flavonoid extracted from Dimorphandra gardneriana, exhibits antioxidant, anti-inflammatory, cytoprotective, gastroprotective properties. However, effect of RUT on intestine, especially mucositis promoted antineoplastic agents, has not yet been reported. In this study, we...
Bioactive compounds extracted from natural sources can benefit human health. The aim of this work was to determine total phenolic content and antioxidant activity in extracts Euphorbia tirucalli L. followed by identification quantification the compounds, as well their antibacterial activities. Antioxidant activities were determined DPPH ABTS(•+) assay. Identification performed using high-performance liquid chromatography (HPLC), antimicrobial verified agar dilution methods MIC values. Total...
Schistosomiasis is a parasitic flatworm disease that infects over 200 million people worldwide, especially in poor communities. Treatment and control of the rely on just one drug, praziquantel. Since funding for drug development poverty-associated diseases very limited, repurposing promising strategy. In this study, from screening 13 marketed diuretics, we identified spironolactone, potassium-sparing diuretic, had potent antischistosomal effects Schistosoma mansoniin vitro vivo murine model...
Pilocarpus microphyllus Stapf ex Wardlew (Rutaceae), popularly known as jaborandi, is a plant native to the northern and northeastern macroregions of Brazil. Several alkaloids from this species have been isolated. There are few reports antibacterial anthelmintic activities for these compounds. In work, we report activity five found in P. leaves, namely, pilosine, epiisopilosine, isopilosine, epiisopiloturine macaubine. Of these, only one compounds has previously reported. Nuclear magnetic...
Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), chemotherapeutic agent used for cancer treatment. Troxerutin (TRX), semi-synthetic flavonoid extracted from Dimorphandra gardneriana, has been reported as potent antioxidant and anti-inflammatory agent. In the present study, we aimed to evaluate effect of TRX on 5-FU-induced intestinal mucositis. Swiss mice were randomly divided into seven groups: Saline, 5-FU, TRX-50, TRX-100, TRX-150, Celecoxib (CLX), CLX...
RESUMO O uso de plantas medicinais no tratamento doenças é uma estratégia antiga utilizada por praticamente todas as populações do mundo, e, embora novos antibióticos tenham sido desenvolvidos para o controle micro-organismos infecciosos, às vezes são ineficazes. Diversos extratos têm efeitos antimicrobianos, principalmente quando associados à clínico, representando alternativa terapêutica infecciosas. Montrichardia linifera, conhecida popularmente como aninga, espécie macrófita, aquática...
Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), chemotherapeutic agent used for cancer treatment. Cashew gum (CG) has been reported as potent anti-inflammatory agent. In the present study, we aimed to evaluate effect of CG extracted from exudate Anacardium occidentale L. on experimental intestinal induced by 5-FU. Swiss mice were randomly divided into seven groups: Saline, 5-FU, 30, 60, 90, Celecoxib (CLX), and CLX + 90 groups. The weight was measured...
The potential emergence of zoonotic diseases has raised significant concerns, particularly in light the recent pandemic, emphasizing urgent need for scientific preparedness. bioprospection and characterization new molecules are strategically relevant to research development innovative drugs viral bacterial treatment disease management. Amphibian species possess a diverse array compounds, including antimicrobial peptides. This study identified first bioactive peptide from Salamandra...
With a broad ethnopharmacological tradition in Brazil, Montrichardia linifera has been reported as potent antirheumatic, antimicrobial, and antiprotozoan agent. However, there is lack of studies on its effect bacterial biofilm formation Schistosoma mansoni worms. This study reports the effects antibacterial, antibiofilm, antischistosomal properties leaf extracts M. linifera. Phytochemical screening identification main compounds were performed. All evaluated showed antibacterial activity at...
Schistosomiasis, caused by helminth flatworms of the genus Schistosoma, is an infectious disease mainly associated with poverty that affects millions people worldwide. Since treatment for this relies only on use praziquantel, there urgent need to identify new antischistosomal drugs. Piplartine amide alkaloid found in several Piper species (Piperaceae) exhibits properties. The aim study was evaluate structure–function relationship between piplartine and its five synthetic analogues (19A, 1G,...
Pilocarpus microphyllus Stapf ex Wardleworth (jaborandi, Rutaceae) is one of the most important Brazilian medicinal species owing to its content pilocarpine (PIL), an alkaloid used for treating glaucoma and xerostomia. This contains another alkaloid, epiisopiloturine (EPI), which has demonstrated effectiveness against schistosomiasis. The aim this work was assess seasonal changes PIL EPI in three populations cultivated P. from northeastern Brazil over year, including dry rainy seasons....
Pilocarpus microphyllus Stapf ex Wardlew. (jaborandi) is native to the North and Northeast regions of Brazil. Intensive exploitation for extraction pilocarpine, a valuable alkaloid pharmaceutical industry, has killed off or brought about loss vigor naturally occurring plant populations. As result, species officially listed as an endangered Brazilian flora. Genetic diversity required adaptation populations environmental changes, maintaining it central objective biological conservation. ISSRs...