A5024810271- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Essential Oils and Antimicrobial Activity
- Phytochemistry Medicinal Plant Applications
- Plant biochemistry and biosynthesis
- Marine Sponges and Natural Products
- Genomics, phytochemicals, and oxidative stress
- Research on Leishmaniasis Studies
- Ethnobotanical and Medicinal Plants Studies
- Polysaccharides and Plant Cell Walls
- Polysaccharides Composition and Applications
- Enzyme function and inhibition
- Trypanosoma species research and implications
- Phytochemistry and Bioactivity Studies
- Tannin, Tannase and Anticancer Activities
- Bioactive Natural Diterpenoids Research
- Hydrogels: synthesis, properties, applications
- Phytochemical compounds biological activities
- Pharmacological Effects of Medicinal Plants
- Phytochemistry and Bioactive Compounds
Universidade Federal do Delta do Parnaíba
2020-2024
Universidade Federal do Amazonas
2020-2024
Universidade Federal do Piauí
2015-2019
Universidade Federal do Ceará
2009-2017
Departamento de Ciência e Tecnologia
2012
Universidade Federal Fluminense
2010
Hospital Universitário Clementino Fraga Filho
2005
The cytotoxicities of five nor-²-lapachone-based 1,2,3-triazoles and the precursor azidonaphthoquinone were assayed against six neoplasic cancer cell lines: SF-295 (central nervous system), HCT-8 (colon), MDAMB-435 (melanoma), HL-60 (leukaemia), PC-3 (prostate) B-16 (murine melanoma). IC50 values ranging from 0.43 to 9.48 µM obtained. 3-(4-(1-hydroxycyclohexyl)-1H-1,2,3-triazol-1yl)-2,2-dimethylnaphtho[1,2-b]furan-4,5-dione proved highly cytotoxic MDAMB-435, with even lower than one...
The cytotoxicity of nine naphthoquinones (NQ) was assayed against HL-60 (leukaemia), MDA-MB-435 (melanoma), SF-295 (brain) and HCT-8 (colon), all human cancer cell lines, peripheral blood mononuclear cells (PBMC), as representatives normal cells, after 72h incubation. 5-Methoxy-1,4-naphthoquinone the most active compound, showing IC(50) values in range 0.31 (1.7microM) to 0.88microg/mL (4.7microM) 0.69microg/mL (3.7microM) PBMC. With introduction a bromo-substituent position 2 or 3 juglone,...
A Plumeria pudica produz um látex rico em proteínas (PLPp) com propriedades anti-inflamatórias, antinociceptivas e antidiarreicas, além de reduzir a periodontite atuar como protetor na colite ulcerativa. O presente estudo teve objetivo avaliar os efeitos das do mucosite intestinal induzida por 5-fluorouracil, forma contribuir informações significativas para solução desse problema e, se possível, tornar-se uma ferramenta terapêutica intestinal. Para tal, fêmeas camundongos da linhagem Balb/c...
Secondary metabolites such as flavonoids bring a range of biological properties to natural products, making them potential candidates for the pharmaceutical industry. Piptadenia stipulacea (Benth.) Ducke is well known in Brazil Jurema Branca, and yet few studies have investigated its phytochemical properties. This study aimed characterize evaluate ethanolic extract obtained from bark Branca. Characterization was performed by qualitative phytochemistry, HPLC, mass spectroscopy. The...
In this study, the cytotoxicity, genotoxicity and early ROS generation of 2,2-dimethyl-(3H)-3-(N-3'-nitrophenylamino)naphtho[1,2-b]furan-4,5-dione (QPhNO(2)) were investigated compared with those its precursor, nor-beta-lapachone (nor-beta), main goal proposing a mechanism antitumor action. The results correlated obtained from electrochemical experiments held in protic (acetate buffer pH 4.5) aprotic (DMF/TBABF(4)) media presence absence oxygen dsDNA biosensors ssDNA solution, which provided...
Previous studies have reported the anti-obesity effects of α, β-Amyrin in high fat-fed mice. This study aimed to evaluate whether has an anti-adipogenic effect 3T3-L1 murine adipocytes and explore possible underlying mechanisms. pre-adipocytes were differentiated a medium containing insulin, dexamethasone, 1-methyl-3-isobutylxanthine. Cytotoxicity was assessed by MTT assay. Lipid content determined Oil-Red O staining. In addition, protein expression levels peroxisome proliferator-activated...
The first examples of platinum(II) complexes 3-(aminomethyl)naphthoquinone Mannich bases have been synthesised and their crystal structures are described. Neutral charged obtained, fully characterised cytotoxic activities also investigated. 3-[(R1-amino)(pyridin-2-yl)methyl]-2-hydroxy-1,4-naphthoquinones (R1 = n-Bu, HL1; Bn, HL2; furfuryl, HL3; n-heptyl, HL4 n-decyl, HL5) coordinate to through the two nitrogen atoms. neutral cis-[Pt(HL)Cl2] 1a–5a analogous cisplatin with bidentate ligand HL...
(+)-Cordiaquinone J is a 1,4-naphthoquinone isolated from the roots of Cordia leucocephala that has antifungal and larvicidal effects. However, cytotoxic effects (+)-cordiaquinone have never being explored. In present study, effect on tumor cells viability was investigated, showing IC(50) values in range 2.7-6.6muM HL-60 SF-295 cells, respectively. Studies performed leukemia indicated (1.5 3.0muM) reduces cell 5-bromo-2-deoxyuridine incorporation after 24h incubation. showed rapid induction...
Herbal compounds rich in triterpenes are well known to regulate glucose and lipid metabolism have beneficial effects on metabolic disorders. The present study investigated the antiobesity properties of resin from Protium heptaphyllum (RPH) possible mechanisms mice fed a high-fat diet (HFD) for 15 weeks. Mice treated with RPH showed decreases body weight, net energy intake, abdominal fat accumulation, plasma glucose, amylase, lipase, triglycerides, total cholesterol relative their respective...
Biflorin, an ortho-naphthoquinone, is active compound found in the roots of Capraria biflora L. It has been reported that biflorin presents anticancer activity, inhibiting both tumor cell line growth culture and development mice. The aim this study was to examine effectiveness treatment using in-vitro in-vivo melanoma models. Biflorin displayed considerable cytotoxicity against all tested lines, with half maximal inhibitory concentration values ranging from 0.58 μg/ml NCI H23 (human lung...
A new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic (3), ent-trachyloban-19-ol (4), ent-kaur-16-en-19-oic (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic (7). submitted to derivatization reactions affording four compounds (8-11). Cytotoxic activity 1, 3, 4, 7-11 against three human cancer cell lines evaluated. No...
Salinaphthoquinones A–E (1–5) were isolated from a marine Salininispora arenicola strain, recovered sediments of the St. Peter and Paul Archipelago, Brazil. The structures compounds elucidated using combination spectroscopic (NMR, IR, HRESIMS) data, including single-crystal X-ray diffraction analysis. A plausible biosynthetic pathway for 1–5 is proposed. Compounds 1 to 4 displayed moderate activity against Staphylococcus aureus Enterococcus faecalis with MIC values 125 16 μg/mL.
Several studies have demonstrated the cytotoxic potential of nor-β-lapachone derivative against cancer cells. Considering as an important prototype, a set new 3-substituted nor-β-lapachones was synthesized by synthetic route that involves use intermediate generated for coupling with several nucleophiles containing carbohydrate and 2H-pyrazole substituent moieties. All compounds were screened four tumor cell lines. Two showed moderate cytotoxicity, while other strongly inhibit all tested