A5065701177- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Sesquiterpenes and Asteraceae Studies
- Pain Mechanisms and Treatments
- Ginger and Zingiberaceae research
- Plant Toxicity and Pharmacological Properties
- Psidium guajava Extracts and Applications
- Natural Antidiabetic Agents Studies
- Drug Transport and Resistance Mechanisms
- Phytochemicals and Antioxidant Activities
- Mangiferin and Mango Extracts
- Helicobacter pylori-related gastroenterology studies
- Bioactive Natural Diterpenoids Research
- Traditional and Medicinal Uses of Annonaceae
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Bioactive Compounds and Antitumor Agents
- Immune Cell Function and Interaction
- Diet, Metabolism, and Disease
- Neuroendocrine regulation and behavior
- Phytochemistry Medicinal Plant Applications
- Radiation Effects and Dosimetry
- Phytochemistry and Bioactive Compounds
Universidade Federal do Ceará
2010-2021
Pertamina (Indonesia)
2016
Instituto Nacional do Semiárido
2013
Government of Karnataka
2012
Brigham and Women's Hospital
2000
Universidade de Fortaleza
1991-2000
Bhabha Atomic Research Centre
1978-1994
Sri Venkateswara Veterinary University
1992
Yale University
1978
Post Graduate Institute of Medical Education and Research
1972-1974
1,8-Cineole (cineole), a terpenoid oxide present in many plant essential oils displays an inhibitory effect on some types of experimental inflammation rats, i.e. paw oedema induced by carrageenan and cotton pellet-induced granuloma. Cineole also inhibits mice, the acetic acid-induced increase peritoneal capillary permeability chemical nociception intraplantar formalin intraperitoneal acid. Activity was these tests, at oral dose range 100–400 mg/kg. In test, antinociceptive cineole not...
Dental caries and periodontal disease are associated with oral pathogens. Several plant derivatives have been evaluated respect to their antimicrobial effects against such pathogenic microorganisms. Lippia sidoides Cham (Verbenaceae), popularly known as "Alecrim-pimenta" is a typical shrub commonly found in the Northeast of Brazil. Many species belonging genus yield very fragrant essential oils potential economic value which used by industry for commercial production perfumes, creams,...
Pentacyclic triterpenes in general exert beneficial effects metabolic disorders. This study investigated the of α, β-amyrin, a pentacyclic triterpene mixture from resin Protium heptaphyllum on blood sugar level and lipid profile normal streptozotocin (STZ)-induced diabetic mice, mice fed high-fat diet (HFD). Mice treated with β-amyrin (10, 30 100 mg/kg, p.o.) or glibenclamide (10 had significantly reduced STZ-induced increases glucose (BG), total cholesterol (TC) serum triglycerides (TGs)....
In the search for potential antiobese agents from natural sources, this study investigated effects of betulinic acid (BA), a pentacyclic triterpene Clusia nemorosa L. (Clusiaceae), in mice on high-fat diet (HFD). Adult male Swiss (n = 8) treated or not with BA (50 mg/L, drinking water) were fed HFD during 15 weeks. Mice and showed significantly (P < 0.05) decreased body weights, abdominal fat accumulation, blood glucose, plasma triglycerides, total cholesterol relative to their respective...
Myrcene, a monoterpene isolated from lemon grass oil (Cymbopogon citratus) has been investigated for antinociception in mice by low temperature (51.5 +/- 0.5 degrees C) hot plate method and the acetic acid-induced writhing test. Significant inhibition of nociception was seen tests with myrcene at doses 10 20 mg kg-1 (i.p.) or 40 (s.c.), respectively. The antinociceptive effect significantly antagonized naloxone (1 kg-1) yohimbine (2 kg-1). results suggest that is capable inducing mice,...
Addition of normal C57BL/6 mouse bone marrow cells to an in vitro culture spleen and allogeneic P815-Y tumor inhibited the development cell-mediated immunity. Bacillus Calmette-Guérin (BCG) enhanced suppressive activity these as early 2 days after its intravenous administration donor mice elicited similar by 7 days. Concomitant with appearance suppressor there was a decrease cell number increase number. While failed inhibit immunization, from thymectomized, irradiated, marrow-reconstituted...
Acute pancreatitis (AP) is an inflammatory condition wherein pro-inflammatory mediators, oxidative stress, and NF-κB signaling play a key role. Currently, no specific therapy exists treatment mainly supportive targeted to prevent local pancreatic injury systemic complications. This study was aimed examine whether 1,8-cineole, plant monoterpene with antioxidant anti-inflammatory properties could ameliorate cerulein-induced acute pancreatitis.AP induced in Swiss mice by six one hourly...
Currently, there is renewed interest in plant-based medicines and functional foods for the prevention cure of obesity its associated risk cardiovascular disease metabolic syndrome. In search potential anti-obesity compounds from natural sources, effects ursolic acid (UA), a pentacyclic triterpenoid widely found medicinal herbs fruits, was evaluated on blood glucose, lipids, abdominal fat deposition mice fed high-fat diet (HFD). Adult male Swiss treated or not with UA (0.05%, 50 mg/L,...
The study was designed to verify the gastroprotective and antidiarrhoeal effects of ternatin, a tetramethoxyflavone isolated from Egletes viscosa Less. function ternatin evaluated in rats against gastric mucosal damage induced by hypothermic restraint stress, absolute ethanoi, indomethacin, whereas activity investigated studying its influence on gastrointestinal transit as measured charcoal marker castor oil-induced accumulation intestinal fluid mice also contractile responses evoked...
Abstract The wound healing activity of oleo‐resin from Copaifera langsdorffii Desf. (Leguminaceae) bark was evaluated in rats on experimental wounds. tested by monitoring contraction excised wounds and measuring tensile strength incision topical application at a concentration 4% accelerated open mean values treated day 9 84.05% ± 2.37% as against 51.29% 9.54% seen controls the difference statistically significant ( p < 0.05). No differences rates were observed days 12, 15, 18 21. Also,...
Corrected by: Gastroprotective Effect of Mangiferin, a Xanthonoid from Mangifera indica, against Gastric Injury Induced by Ethanol and Indomethacin in RodentsPlanta Med 2007; 73(14): 1522-1522DOI: 10.1055/s-2007-993751
Previous studies have reported on the glucose and lipid-lowering effects of ferulic acid (FA) but its anti-obesity potential has not yet been firmly established. This study investigated possible anti-obesitogenic FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess antiobesity FA, 32 male Swiss mice, weighing 20-25 g (n=6-8 per group) were normal (ND) or HFD, treated orally with either (10 mg/kg) sibutramine weeks at end this period, body weights animals, visceral fat accumulation,...