A5040209491- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Polysaccharides Composition and Applications
- Analytical Methods in Pharmaceuticals
- Layered Double Hydroxides Synthesis and Applications
- Crystallization and Solubility Studies
- Ginkgo biloba and Cashew Applications
- Analytical Chemistry and Chromatography
- Trypanosoma species research and implications
- biodegradable polymer synthesis and properties
- HIV/AIDS drug development and treatment
- Clay minerals and soil interactions
- Leprosy Research and Treatment
- Mesoporous Materials and Catalysis
- Magnesium Oxide Properties and Applications
- Polysaccharides and Plant Cell Walls
- Thermal and Kinetic Analysis
- Advancements in Transdermal Drug Delivery
- Healthcare during COVID-19 Pandemic
- Pharmacological Effects of Natural Compounds
- Antibiotics Pharmacokinetics and Efficacy
- Science and Education Research
- Nanocomposite Films for Food Packaging
- Protein purification and stability
- Therapeutic Uses of Natural Elements
Universidade Federal de Pernambuco
2016-2025
Centro Universitário da Cidade
2024
Escola Superior de Saúde Egas Moniz
2019
Escola Superior de Enfermagem de Lisboa
2019
Universidade Federal do Piauí
2010-2017
Sarah Network of Rehabilitation Hospitals
2015
Universidade Federal de Sergipe
2011
Instituto Adolfo Lutz
1973
Benznidazole (BNZ), the only commercialized antichagasic drug, and antifungal compound posaconazole (PCZ) have shown synergistic action in therapy of Chagas disease, however both active pharmaceutical ingredients (APIs) exhibit low aqueous solubility potentially limiting their bioavailability therapeutic efficacy. In this paper, we report for first time formation a eutectic mixture as well an amorphous solid solution PCZ BNZ (at same characteristic ratio 80:20 wt%), which provided enhanced...
This study addresses a new application for simultaneous quantification of clofazimine (CLZ) and dapsone (DAP) in combined fixed-dose formulation evaluation their vitro release profile using UV-Vis spectroscopy, with partial least squares regression (PLS) multivariate curve resolution (MCR-ALS). High-Performance Liquid Chromatography Photodiode Array Detector (HPLC-PDA) was the reference method comparing models. Both models underwent validation external sample sets were applied to analysis...
Abstract Poly(methyl methacrylate) (PMMA) is a polymer that can be used in applications requiring its exposition to gamma radiation, nevertheless, the radiation induces main chain scission backbone, leading modification some properties. Therefore, using materials such as layered double hydroxide (LDH), was evaluated new shielding agent. This work synthesized LDH and added PMMA by an in-situ polymerization method. Viscosimetric analysis showed at 0.25 wt% concentration promotes radiolytic...
A pandemia de COVID-19 revelou fragilidades significativas no sistema saúde brasileiro, destacando a dependência insumos importados e os desafios logísticos enfrentados pelo Sistema Único Saúde (SUS). Este estudo analisa resiliência do SUS, abordando as dificuldades enfrentamento da crise sanitária o papel das políticas públicas para fortalecer cadeia produtiva nacional medicamentos biotecnologias, manejo Covid-19 colocou em prova (SUS) por requerer estruturas hospitalares robustas que...
ABSTRACT Analysis of Cryptosporidium occurrence in six watersheds by method 1623 and the integrated cell culture-PCR (CC-PCR) technique provided an opportunity to evaluate these two methods. The average recovery efficiencies were 58.5% for CC-PCR 72% 1623, but values not significantly different ( P = 0.06). oocysts detected 60 593 samples (10.1%) 1623. Infectious 22 560 (3.9%) technique. There was 87% agreement between total numbers positive as determined four sites. other sites had 16.3 24%...
Benznidazole (BNZ) is the drug of choice for Chagas disease treatment, which affects about 9.8 million people worldwide. It has low solubility and high toxicity. The present study aimed to develop characterize inclusion complexes (IC) in binary systems (BS) with BNZ randomly methylated-β-cyclodextrin (RMβCD) ternary (TS) BNZ, RMβCD hydrophilic polymers. results showed that solid BS had a large increase dissolution rate (Q > 80%). For IC obtained, kneading method, ratio 1:0.17 (77.8% 60 min),...