A5024352337- Essential Oils and Antimicrobial Activity
- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Drug Solubulity and Delivery Systems
- Bee Products Chemical Analysis
- Phytochemistry and Biological Activities
- COVID-19 Clinical Research Studies
- Lichen and fungal ecology
- Natural product bioactivities and synthesis
- Hereditary Neurological Disorders
- Analytical Methods in Pharmaceuticals
- Botulinum Toxin and Related Neurological Disorders
- Analytical Chemistry and Chromatography
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 epidemiological studies
- Crystallization and Solubility Studies
- SARS-CoV-2 and COVID-19 Research
- Bioactive Compounds and Antitumor Agents
- Phytochemicals and Antioxidant Activities
- Morinda citrifolia extract uses
- Pharmacology and Obesity Treatment
- Plant-based Medicinal Research
- Medicinal plant effects and applications
Universidade Federal de Sergipe
2016-2025
Secretaria do Meio Ambiente
2022
Brazilian Institute of Environment and Renewable Natural Resources
2022
Instituto de Desenvolvimento Sustentável Mamirauá
2022
Instituto de Ciências Farmacêuticas
2016-2021
Research Institute of Human Morphology
2021
University Health Care System
2021
Physiotherapy New Zealand
2021
Weatherford College
2021
National Council for Scientific and Technological Development
2021
We examined the antioxidant properties in vitro and antinociceptive effect of carvacrol (CARV) several models pain mice. CARV presented a strong potential according to TRAP/TAR evaluation; it also scavenger activity against nitric oxide prevented lipid peroxidation vitro. In mice, when evaluated acetic acid-induced abdominal writhing, (25, 50 100 mg/kg, i.p.) reduced (p < 0.001) number writhing compared control group, without opioid participation. formalin test, significantly inhibited both...
Previously, we have demonstrated the analgesic-like property of p-cymene in rodents. Short half-life is a limitation for application and several approaches been used to improve pharmaceutical properties monoterpenes, including employment drug-delivery systems. Here, p-cymene/β-cyclodextrin (β-CD) complex (PC) isolated evaluated whether formulation able antinociceptive activity this monoterpene. Male mice (26-30g) were pretreated with PC/β-CD (20 or 40mg/kg, p.o.), PC p.o.) vehicle (distilled...
Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, geranyl acetate in vivo vitro experimental models. Methods. Evaluation antioxidant activity using different free radical-generating systems evaluation antinociceptive actions by acetic acid-induced writhing formalin-induced nociception tests mice. Results. p-Cymene has strongest effect, but (+)-camphene also present significant at high doses (200 mg/kg). (+)-Camphene had effect TBARS...
The aim of this study was assess the effect collagen‐based films containing usnic acid as a wound dressing for dermal burn healing. Second‐degree wounds were performed in forty‐five Wistar rats, assigned into nine groups: COL—animals treated with films; PHO—animals collagen empty liposomes; UAL—animals incorporated liposomes. After 7, 14, and 21 days animals euthanized. On 7th day there moderate infiltration neutrophils, UAL, distributed throughout wounds, whereas COL PHO, severity reaction...
Many plants produce (-)-linalool, a plant-derived monoterpene alcohol, including members of the Lamiaceae (mints) and Lauraceae family (laurels, cinnamon, rosewood). The anti-inflammatory analgesic effects (-)-linalool have been widely suggested for various studies. Poor chemical stability short half-life restrain clinical applications some essential oil monoterpenes, (-)-linalool. However, β-cyclodextrin (β-CD) has used to increase solubility lipophilic compounds also improve...