A5073188396- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Drug Solubulity and Delivery Systems
- Plant-based Medicinal Research
- Bee Products Chemical Analysis
- Phytochemistry Medicinal Plant Applications
- Pharmacology and Obesity Treatment
- Natural Antidiabetic Agents Studies
- Botulinum Toxin and Related Neurological Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuropeptides and Animal Physiology
- Computational Drug Discovery Methods
- Phytochemistry and Bioactive Compounds
- Muscle metabolism and nutrition
- Analytical Methods in Pharmaceuticals
- SARS-CoV-2 and COVID-19 Research
- Healthcare and Venom Research
- Plant Toxicity and Pharmacological Properties
- COVID-19 Clinical Research Studies
- Phytochemicals and Antioxidant Activities
- Herbal Medicine Research Studies
- Analytical Chemistry and Chromatography
Universidade Federal de Sergipe
2015-2024
Universidade Tiradentes
2021
Brazilian Network Information Center
2020
Faculdades Guarulhos
2020
Universidade Federal do Vale do São Francisco
2014-2017
Universidade São Francisco
2017
Universidade Federal do Rio Grande do Sul
2013
Universidade Federal de Ciências da Saúde de Porto Alegre
2013
Borneol, a bicyclic monoterpene, has been evaluated for antinociceptive and anti‐inflammatory activities. Antinociceptive activities were studied by measuring nociception acetic acid, formalin, hot plate, grip strength tests, while inflammation was prompted carrageenan‐induced peritonitis. The rotarod test used to evaluate motor coordination. Borneol produced significant ( P < 0.01) reduction of the nociceptive behavior at early late phases paw licking reduced writhing reflex in mice...
Previously, we have demonstrated the analgesic-like property of p-cymene in rodents. Short half-life is a limitation for application and several approaches been used to improve pharmaceutical properties monoterpenes, including employment drug-delivery systems. Here, p-cymene/β-cyclodextrin (β-CD) complex (PC) isolated evaluated whether formulation able antinociceptive activity this monoterpene. Male mice (26-30g) were pretreated with PC/β-CD (20 or 40mg/kg, p.o.), PC p.o.) vehicle (distilled...
Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, geranyl acetate in vivo vitro experimental models. Methods. Evaluation antioxidant activity using different free radical-generating systems evaluation antinociceptive actions by acetic acid-induced writhing formalin-induced nociception tests mice. Results. p-Cymene has strongest effect, but (+)-camphene also present significant at high doses (200 mg/kg). (+)-Camphene had effect TBARS...
Phytol is a diterpene constituent of chlorophyll and has been shown to have several pharmacological properties, particularly in relation the management painful inflammatory diseases. Arthritis one most common these diseases, mainly affecting synovial membrane, cartilage, bone joints. Proinflammatory cytokines, such as TNF-α IL-6, NFκB signaling pathway play pivotal role arthritis. However, mechanisms action phytol its ability reduce levels cytokines are poorly understood, we decided...