A5081571608- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Botulinum Toxin and Related Neurological Disorders
- Drug Solubulity and Delivery Systems
- Healthcare and Venom Research
- Essential Oils and Antimicrobial Activity
- Neonatal and Maternal Infections
- Migraine and Headache Studies
- Neuropeptides and Animal Physiology
- Drug-Induced Hepatotoxicity and Protection
- Ion channel regulation and function
- Nerve injury and regeneration
- Rheumatoid Arthritis Research and Therapies
- Biochemical effects in animals
- Ocular Surface and Contact Lens
- Phytochemistry and Bioactive Compounds
- Immune Response and Inflammation
- Nanoparticle-Based Drug Delivery
- Pediatric Pain Management Techniques
- Bee Products Chemical Analysis
- Pain Management and Opioid Use
- Neonatal and fetal brain pathology
- Phytochemistry Medicinal Plant Applications
Universidade Federal de Sergipe
2016-2024
Brazilian Network Information Center
2020
Phytol is a diterpene constituent of chlorophyll and has been shown to have several pharmacological properties, particularly in relation the management painful inflammatory diseases. Arthritis one most common these diseases, mainly affecting synovial membrane, cartilage, bone joints. Proinflammatory cytokines, such as TNF-α IL-6, NFκB signaling pathway play pivotal role arthritis. However, mechanisms action phytol its ability reduce levels cytokines are poorly understood, we decided...
Sepsis is an amplified systemic immune-inflammatory response produced by a microorganism, which involves activation of inflammatory cytokine signaling pathways and oxidative stress. A variety studies have shown that hydralazine (HDZ) has potent antioxidant anti-inflammatory proprieties. Therefore, we hypothesize HDZ can improve the clinical outcome sepsis. Thus, this work aimed to evaluate therapeutic value in reducing response, stress, mortality animal sepsis, investigate its possible...
Miconia albicans (Sw) Triana (Melastomataceae), a medicinal plant widely used by practitioners of folk medicine in the northeast Brazil, has been to treat chronic inflammatory disorders, such as rheumatoid arthritis (RA) and other joint conditions. Oddly, there is little research on species. We aimed evaluate anti-arthritic anti-inflammatory profile ethanolic leaf extract M. (EEMA), well perform dereplication quantification HPLC-DAD-ESI-/MS/MS. The compounds present extracts were identified...
To test for the possible antinociceptive effect of nifedipine in rodent models acute and chronic neuropathic orofacial pain involvement TRP- NMDA-related processes this effect.Acute nociceptive behavior was induced by administering formalin, cinnamaldehyde, glutamate, capsaicin, or acidified saline to upper lip hypertonic cornea Swiss mice. Acute also formalin injected into TMJ mustard oil masseter muscle Wistar rats. The model involved infraorbital nerve transection (IONX) rats induce...
Inflammatory arthritis is the most prevalent chronic inflammatory disease worldwide. The pathology of characterized by increased inflammation and oxidative stress, which leads to pain functional loss in joints. Conventional anti-arthritic drugs used relieve other arthritic symptoms often cause severe side effects. α-bisabolol (BIS) a sesquiterpene that exhibits high anti-inflammatory potential significant antinociceptive effect. This study evaluates anti-arthritic, antihyperalgesic effects...
Neuropathic pain (NP) is a difficult condition to treat because of the modest efficacy available drugs. New treatments are required. In study we aimed investigate effects essential oil from Lippia grata alone or complexed in β-cyclodextrin (LG LG-βCD) on persistent inflammatory and neuropathic mouse model. We also investigated Ca2+ currents rat dorsal root ganglion (DRG) neurons. Male Swiss mice were treated with LG LG/β-CD (24 mg/kg, i.g.) their effect was evaluated using an acute pleurisy...