A5085004030- Pain Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
- Zebrafish Biomedical Research Applications
- Phytochemistry Medicinal Plant Applications
- Neurobiology and Insect Physiology Research
- Biochemical Analysis and Sensing Techniques
- Ion Channels and Receptors
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Insect Pest Control Strategies
- Neuroscience and Neuropharmacology Research
- Bee Products Chemical Analysis
- Healthcare and Venom Research
- Poisoning and overdose treatments
- Sleep and Wakefulness Research
- Phytochemicals and Antioxidant Activities
- Biological and pharmacological studies of plants
- Botulinum Toxin and Related Neurological Disorders
- Stress Responses and Cortisol
- Polysaccharides and Plant Cell Walls
- Olfactory and Sensory Function Studies
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Plant Toxicity and Pharmacological Properties
- Alkaloids: synthesis and pharmacology
Universidade de Fortaleza
2016-2025
Universidade Federal do Ceará
1999-2024
Universidade Estadual do Ceará
2012-2024
Universidade Federal de Campina Grande
2024
University of South Florida
2023-2024
Poznan University of Medical Sciences
2023
Hospital Británico de Buenos Aires
2022
Florida College
2022
University of Florida
2022
Hospital Británico
2022
The zebrafish (Danio rerio) has been proposed as a low-cost and simple alternative to the use of higher vertebrates in laboratory research on novel compounds with antinociceptive potential. In this study, we tested adult an behavioral model formalin-induced nociception. We evaluated nociceptive effect 0.1% formalin (3 or 5 μL; intramuscularly [i.m.]), applied into tail lips, locomotor activity, using parameter number times fish crossed lines between quadrants glass Petri dish during...
Neem fruit (Azadirachta indica A. Juss.) are popularly used to treat infections, diarrhea, fever, bronchitis, skin diseases, infected burns and hypertension. Although the antinociceptive anti-inflammatory potential of has already been investigated in experimental models pain inflammation mice, current research is first report evaluation capacity ethanolic extract (EtFrNeem) acute attenuation using adult zebrafish (Danio rerio) as an alternative model use rodents. EtFrNeem was submitted...
The use of medicinal plants with therapeutics properties represents a secular tradition in different cultures, mainly underdeveloped countries. Lantana camara Linn and montevidensis Briq (Verbenaceae) found tropical subtropical areas around the world are popularly known as "camará" or "chumbinho." In popular medicines, both used antipyretic carminative treatment respiratory system infections. this study, antibacterial activity ethanolic extracts L. leaves roots against gram-positive...
Aedes aegypti and albopictus are important vectors that transmit arboviruses to human populations.Natural products were obtained tested against larvae collected from the field in Fortaleza, capital of Ceará state.The essential oils Syzygium aromaticum (Ae. LC50 = 32.7 ppm Ae. 138.1 ppm) Croton nepetaefolius 81.7 76.1 showed most intense larvicidal activity.The methyl esters greater activity than did ethanol extracts.
The effects of Matricaria recutita and alpha-bisabolol, a bioactive component from Chamomile species, were investigated against gastric damage induced by absolute ethanol (96%, 1 mL per animal) in rats. M. extract alpha-bisabolol on mucosal assessed determination changes mean lesion area. Mechanistic studies carried out at with 100 mg=kg alpha-bisabolol. We further examined the possible participation prostaglandins, nitric oxide, KATP+ channels its mechanism. reduced all doses tested....
This study aimed to evaluate the antinociceptive effect of oleanolic acid using adult zebrafish models orofacial pain. Acute nociception was induced by formalin, capsaicin, cinnamaldehyde, menthol, acidified saline or glutamate (cutaneous modes) and hypertonic (corneal model). In another set experiments, animals were pre-treated with naloxone, L-NAME, methylene blue, ketamine, camphor, HC-030031, mefenamic acid, ruthenium red amiloride investigate mechanism antinociception. The involvement...
Guarana, a herbal extract from the seeds of Paullinia cupana Mart. has been evaluated in comparison with caffeine on mouse behaviour forced swimming and open field tests. Guarana (25 50 mg/kg, p.o.) (10 20 each significantly reduced duration immobility test suggesting an antidepressant-like effect mice. At these doses, neither substance affected ambulation test. However, high dose guarana (100 mg/kg) (30 enhanced locomotor activity Caffeine, but not guarana, could effectively block adenosine...
Plectranthus is one of the most representative genera Lamiaceae family. In this study, essential oils from amboinicus , ornatus and barbatus were investigated for their chemical composition antimicrobial modulatory activities. The major components found carvacrol (54.4%— P. ) eugenol (22.9%— e 25.1%— ). vitro activity was conducted against Escherichia coli Proteus vulgaris Bacillus cereus Pseudomonas aeruginosa Staphylococcus aureus (multiresistant) using microdilution method. results...
Zebrafish is an excellent model that can be utilized as adjunct to current rodent models for studies of eye diseases because the anatomy and ultrastructural characterization its cornea show much similarity with human cornea. Therefore, we developed a behavioral corneal nociception using adult zebrafish (Danio rerio). We analyzed nociceptive effect hypertonic saline (0.15–5.0 M sodium chloride [NaCl]) applied surface right or left cornea, on animals' gender locomotor activity through...