A5034681854- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Carbon and Quantum Dots Applications
- Radiopharmaceutical Chemistry and Applications
- Nanoparticles: synthesis and applications
- Graphene research and applications
- Force Microscopy Techniques and Applications
- Nanoplatforms for cancer theranostics
- Cellular Mechanics and Interactions
- Bone Tissue Engineering Materials
- Boron Compounds in Chemistry
- RNA Interference and Gene Delivery
- Fungal Infections and Studies
- Blood properties and coagulation
- Titanium Alloys Microstructure and Properties
- Electrospun Nanofibers in Biomedical Applications
- Lipid Membrane Structure and Behavior
- Radiation Therapy and Dosimetry
- Erythrocyte Function and Pathophysiology
- Antimicrobial Peptides and Activities
- Lubricants and Their Additives
- Nanocluster Synthesis and Applications
- Coccidia and coccidiosis research
- Polysaccharides and Plant Cell Walls
- Monoclonal and Polyclonal Antibodies Research
Universidade Federal do Maranhão
2019-2025
Universidade Federal do Ceará
2005-2020
Altera (United States)
2019
Nuclear Engineering Institute
2019
Universidade Federal do Rio de Janeiro
2018
Instituto Federal de Educação, Ciência e Tecnologia do Ceará
2017
Centro Universitário Católica de Quixadá
2016
University of Lisbon
1996
Administração Regional de Saúde de Lisboa e Vale do Tejo
1992
University of the Witwatersrand
1991
The viscoelastic properties of human kidney cell lines from different tumor types (carcinoma (A-498) and adenocarcinoma (ACHN)) are compared to a non-tumorigenic line (RC-124). Our methodology is based on the mapping (elasticity modulus E apparent viscosity η) over surface tens individual cells with atomic force microscopy (AFM). averaged datasets as large 15000 data points per line. We also propose model estimate soft materials using hysteresis observed in conventional AFM...
Cutaneous leishmaniasis caused by Leishmania amazonensis is a significant public health issue. This study aimed to evaluate an ecofriendly, thermosensitive nanogel, developed using low-energy, solvent-free method, incorporating F127 and Carbopol 974P copolymers, enriched with Pectis brevipedunculata essential oil (EOPb) for its leishmanicidal anti-inflammatory properties. The nanogel was prepared characterized through FTIR, DLS, SEM, AFM confirm the incorporation of EOPb as well stability...
The deformation properties of submicrometric drug carriers can influence their tissue-penetration ability and thus the targeting. aim this study was to determine whether oily core composition (raw oils or a dispersion solid lipid) surrounded by polymeric wall [poly(ε-caprolactone), (PCL)] affect nanocapsules (NCs) lipid-core (LNCs). Formulations were prepared as aqueous suspensions using polymer either mixture caprylic/capric triglyceride (CCT) octyl methoxycinnamate (OMC) CCT, OMC sorbitan...
Nanoindentation of soft materials is a growing research field, demanding sophisticated models to extract accurate information from these materials. In this work we investigate the nanoindentation thin films by sharp conical indenters using Finite Elements Modeling. Based on Dimitriadis et al. [Biophys. J. 82, 2798 (2002)], propose that load-displacement (F × δ) curves for can be described F = FHertz(δ)g[χ(δ,h)], where FHertz(δ) regular Hertz model, and g[χ(δ,h)] correction function includes...
Infectious and Parasitic Diseases (IPD) remain a challenge for medicine due to several interconnected reasons, such as antimicrobial resistance (AMR). American tegumentary leishmaniasis (ATL) is an overlooked IPD causing persistent skin ulcers that are challenging heal, resulting in disfiguring scars. Moreover, it has the potential extend from mucous membranes of nose, mouth, throat both humans various animals. Given limited effectiveness AMR current drugs, exploration new substances emerged...
Spores of Bacillus subtilis LAMI008 were entrapped in 3-mm chitosan beads and cross-linked with 0.3% glutaraldehyde for n-hexadecane biodegradation biosurfactant recovery. When exposed to nutrients, the spores generated vegetative cells without morphological alterations as revealed by atomic force microscopy. The degraded almost 100% 1% medium supplemented glucose produce within 48 h, well free cells. number viable inside was maintained throughout degradation process released not used a...
Two-dimensional materials exhibit great potential for high-performance electronics applications and the knowledge of their thermal properties is extremely necessary, since they are closely related to efficient heat dissipation electron-phonon interactions. In this study we report temperature-dependence out-of-plane A1g Raman mode suspended supported CVD-grown single-crystalline tungsten diselenide (WSe2) monolayer. The phonon wavenumber linearly red-shifted temperature ranging from 98 513 K,...
Abstract: This study discusses the chemical perspectives of [18F]F-PSMA probe, a pivotal tool in prostate cancer imaging. [18F]Fluorine, positron emitter with half-life 109.8 minutes, is produced cyclotron by bombarding [18O]-enriched targets protons. The chemistry this isotope parallels that stable fluorine, facilitating its use emission tomography (PET). synthesis involves nucleophilic substitution (SN1) reaction, where [18F]fluoride ion replaces leaving group precursor molecule....
Penile cancer (PCa) is a disease that manifests predominantly as squamous cell carcinomas (SCCs), which, although rare, represents significant public health problem, especially in regions with less socioeconomic development. One of the biggest challenges managing this difficulty differentiating tumor subtypes, making accurate diagnosis and treatment challenging. In context, new characterization techniques are needed to investigate these tumors more completely. Atomic force microscopy (AFM)...
This study investigates the potential of arimoclomol-loaded nanomicelles for treatment neurodegenerative diseases like Alzheimer's and Parkinson's, as well their anti-inflammatory properties. Arimoclomol, a coinducer heat shock proteins (HSPs), has shown clinical promise in mitigating protein misfolding, hallmark these diseases. In this work, arimoclomol significantly reduced aggregation β-amyloid (Aβ1–42) α-synuclein (α-syn), key pathological Parkinson's. Additionally, demonstrated potent...
Background: The development of nanostructured materials for cancer therapy has garnered significant interest due to their unique physicochemical properties, including enhanced surface area and tunable electronic structures, which can facilitate targeted drug delivery oxidative stress modulation. This study investigates the anticancer potential monoclinic silver dimolybdate nanorods (m-Ag₂Mo₂O₇) against aggressive breast (MDA-MB-231) prostate (PC-3) cells explores in vivo pharmacokinetic...
Background/Objectives: Lipoxins, particularly Lipoxin A4 (LXA4), are endogenous lipid mediators with potent anti-inflammatory and pro-resolving properties, making them promising candidates for the treatment of inflammatory neurodegenerative disorders. However, their therapeutic application is limited by poor stability bioavailability. This study aimed to develop characterize nanomicelles encapsulating LXA4 (nano-lipoxin A4) improve its pharmacological efficacy against Alzheimer’s disease...