A5016036898- Immune Response and Inflammation
- Synthesis and biological activity
- Malaria Research and Control
- Tuberculosis Research and Epidemiology
- Natural product bioactivities and synthesis
- Nitric Oxide and Endothelin Effects
- Phytochemical compounds biological activities
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Mast cells and histamine
- Mosquito-borne diseases and control
- Inflammatory mediators and NSAID effects
- Essential Oils and Antimicrobial Activity
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Synthesis and Biological Evaluation
- Neuropeptides and Animal Physiology
- NF-κB Signaling Pathways
- Rheumatoid Arthritis Research and Therapies
- Receptor Mechanisms and Signaling
- Phenothiazines and Benzothiazines Synthesis and Activities
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer therapeutics and mechanisms
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
Universidade do Estado do Rio de Janeiro
1985-2025
Fundação Oswaldo Cruz
2015-2024
Universidade de São Paulo
2021
Universidade Federal do Rio de Janeiro
2021
Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais
2016-2018
Computational Physics (United States)
2015
Instituto de Tecnologia e Pesquisa
2005-2011
National Institute of Science and Technology of Drugs and Medicines
2008
Natura (Brazil)
2006
Institut Pasteur
1991
In the Mediterranean evergreen oak woodlands of southern Portugal, main tree species are Quercus ilex ssp. rotundifolia Lam. (holm oak) and suber L. (cork oak). We studied a savannah-type woodland where these coexist, with aim better understanding mechanisms adaptation to seasonal drought. both species, variations in transpiration predawn leaf water potential showed maximum spring followed by decline through rainless summer recovery autumn rainfall. Although observed decrease indicates soil...
Myrtaceae is a plant family widely used in folk medicine and Syzygium Eugenia are among the most important genera. We investigated anti-allergic properties of an aqueous leaf extract cumini (L.) Skeels (SC). HPLC analysis revealed that hydrolyzable tannins flavonoids major components extract. Oral administration SC (25-100 mg/kg) Swiss mice (20-25 g; N = 7/group) inhibited paw edema induced by compound 48/80 (50% inhibition, 100 mg/kg; P <= 0.05) and, to lesser extent, allergic (23% 0.05)....
Lipoxin A(4) (LXA(4)) is a lipid mediator involved in the resolution of inflammation. Increased levels LXA(4) synovial fluid and enhanced expression formyl peptide receptor 2/lipoxin (FPR2/ALX) tissues rheumatoid arthritis patients have been reported. Endothelins (ETs) play pivotal pro-inflammatory role acute articular inflammatory responses. Here, we evaluated anti-inflammatory LXA(4), during phase zymosan-induced arthritis, focusing on modulation ET-1 its effects.The effects BML-111...
Context: Despite the many biological activities reported for essential oils, their anti-inflammatory ability is relatively underexplored considering wide variation in plant sources and volatile composition. Oils from Syzygium cumini Skells (SC) Psidium guajava L. (PG) (Myrtaceae) have been described as having diverse pharmacological activities.Objective: The current study seeks to evaluate activity of oils leaves SC PG, well some terpene-enriched fractions (+V = more −V less volatile)...
Methyl gallate (MG) is a prevalent phenolic acid in the plant kingdom, and its presence herbal medicines might be related to remarkable biological effects, such as antioxidant, antitumor, antimicrobial activities. Although some indirect evidence suggests anti-inflammatory activity for MG, there are no studies demonstrating this effect animal models. Herein, we demonstrated that MG (0.7–70 mg/kg) inhibited zymosan-induced experimental arthritis dose-dependent manner. The oral administration...
Plasmodium falciparum causes the most serious complications of malaria and is a public health problem worldwide with over 2 million deaths each year. The erythrocyte invasion mechanisms by sp. have been well described, however physiological aspects involving host components in this process are still poorly understood. Here, we provide evidence for role renin-angiotensin system (RAS) reducing P. falciparum. Angiotensin II (Ang II) reduced an enriched schizont culture dose-dependent manner....
Ten new mefloquine-oxazolidine derivatives, 4-[(1S,8aR)-3-(aryl)hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinoline (1: aryl=substituted phenyl) and 4-[(1S,8aR)-3-(heteroaryl)hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinoline [2: heteroaryl=5-nitrothien-2-yl (2a); 5-nitrofuran-2-yl (2b) 4H-imidazol-2-yl) (2c)], have been synthesized evaluated against Mycobacterium tuberculosis. Compounds 1f (aryl=3-ethoxyphenyl), 1g...
The injection of 100 or 300 μg carrageenin into the mouse paw pleural cavity produced a delayed inflammatory reaction at 48 h while platelet activating factor (PAF)‐induced oedema and pleurisy were maximal 30 min after its injection. PAF antagonist, WEB 2086, failed to inhibit induced by PAF, but reduced first phase (1–4 h) without interfering with second one (48–72 h). In contrast, another structurally‐related 2170, inhibited dose‐dependently both (48 Repeated injections led significant...