Leonardo Noboru Seito

ORCID: 0000-0003-4027-0577
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Research Areas
  • Essential Oils and Antimicrobial Activity
  • Natural product bioactivities and synthesis
  • Phytochemicals and Antioxidant Activities
  • Immune Response and Inflammation
  • Phytochemistry Medicinal Plant Applications
  • Inflammatory Bowel Disease
  • NF-κB Signaling Pathways
  • Genomics, phytochemicals, and oxidative stress
  • Phytochemical compounds biological activities
  • Inflammatory mediators and NSAID effects
  • Mosquito-borne diseases and control
  • Pharmacological Effects of Medicinal Plants
  • Natural Compound Pharmacology Studies
  • Malaria Research and Control
  • Complement system in diseases
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Veterinary medicine and infectious diseases
  • Advanced Electron Microscopy Techniques and Applications
  • Bioactive natural compounds
  • Medical and Biological Ozone Research
  • Natural Compounds in Disease Treatment
  • melanin and skin pigmentation
  • Bioactive Natural Diterpenoids Research
  • Traditional and Medicinal Uses of Annonaceae

Fundação Oswaldo Cruz
2015-2024

Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais
2018

Universidade Estadual Paulista (Unesp)
2002-2014

Coumarins comprise a broad class of phenolic compounds that influences the formation and scavenging reactive oxygen species processes involving free radical-mediated injury. In light antioxidant anti-inflammatory properties esculetin 4-methylesculetin, aim this study was to investigate effects these in an experimental model rat colitis induced by trinitrobenzenesulphonic acid (TNBS). For purpose, macroscopic (diarrhoea, extension lesion, colonic weight/length ratio damage score) biochemical...

10.1016/j.cbi.2010.03.045 article EN publisher-specific-oa Chemico-Biological Interactions 2010-04-12

Coumarins represent an important class of phenolic compounds with multiple biological activities, including inhibition lipidic peroxidation and neutrophil-dependent anion superoxide generation, anti-inflammatory immunosuppressor actions. All these proprieties are essential for that a drug may be used in the treatment inflammatory bowel disease. The present study examined intestinal activity coumarin its derivative, 4-hydroxycoumarin on experimental ulcerative colitis rats. This was performed...

10.1248/bpb.31.1343 article EN Biological and Pharmaceutical Bulletin 2008-01-01

We aimed to establish a phytochemical analysis of the crude extracts and performed GC-MS essential oils (EOs) Eugenia uniflora L. (Myrtaceae) Asteraceae species Baccharis dracunculifolia DC, Matricaria chamomilla Vernonia polyanthes Less, as well determining their antimicrobial activity. Establishment minimal inhibitory concentrations EOs against 16 Staphylococcus aureus Escherichia coli strains from human specimens was carried out using dilution method in Mueller-Hinton agar. Some phenolic...

10.1080/14786419.2011.564582 article EN Natural Product Research 2011-10-19

Methyl gallate (MG) is a prevalent phenolic acid in the plant kingdom, and its presence herbal medicines might be related to remarkable biological effects, such as antioxidant, antitumor, antimicrobial activities. Although some indirect evidence suggests anti-inflammatory activity for MG, there are no studies demonstrating this effect animal models. Herein, we demonstrated that MG (0.7–70 mg/kg) inhibited zymosan-induced experimental arthritis dose-dependent manner. The oral administration...

10.1021/acs.jnatprod.5b01115 article EN Journal of Natural Products 2016-05-26

Background . This study was pathway of (−)-epicatechin (EC) in the prevention and treatment intestine inflammation acute chronic rat models. Methods Intestine induced rats using TNBS. The morphological, inflammatory, immunohistochemical, immunoblotting characteristics colon samples were examined. effects EC evaluated an model at doses 5, 10, 25, 50 mg/kg by gavage for 5 days. colitis 1st day, treated 21 For relapse model, induction repeated on 14th. Results EC10 EC50 effectively reduced...

10.1155/2012/508902 article EN Evidence-based Complementary and Alternative Medicine 2012-01-01

Abstract Background Inflammatory bowel disease (IBD) is a chronic inflammation of the intestinal epithelium that driven by immune system, oxidative stress and loss tolerance to luminal microbiota. The use dietary products containing ingredients such as fibres carbohydrates and/or antioxidant compounds have been used therapeutic strategy for diseases because these are considered effective in modulation system colonic We investigated beneficial effects cattail rhizome flour ( Typha...

10.1186/1472-6882-12-62 article EN cc-by BMC Complementary and Alternative Medicine 2012-05-04

Abstract Background Exposure to ultraviolet (UV) radiation causes various forms of acute and chronic skin damage, including immunosuppression, inflammation, premature aging photodamage. Furthermore, it induces the generation reactive oxygen species, produces proinflammatory cytokines melanocyte-stimulating hormone (MSH) increases tyrosinase activity. The aim this study was evaluate potential photoprotective effects Rheum rhaponticum L. rhizome extract on human UV-stimulated melanocytes....

10.1186/1472-6882-13-49 article EN cc-by BMC Complementary and Alternative Medicine 2013-02-27

Gedunin, a natural limonoid from Meliaceae species, has been previously described as an antiinflammatory compound in experimental models of allergic inflammation. Here, we report the and antinociceptive effects gedunin acute model articular inflammation induced by zymosan (500 μg/cavity; intra-articular) C57BL/6 mice. Intraperitoneal (i.p.) pretreatment with (0.005–5 mg/kg) impaired zymosan-induced edema formation, neutrophil accumulation hypernociception mouse knee joints, due to decreased...

10.3390/molecules20022636 article EN cc-by Molecules 2015-02-03

A breakdown of the brain-blood barrier (BBB) due to endothelial dysfunction is a primary feature cerebral malaria (CM). Lipoxins (LX) are specialized pro-resolving mediators that attenuate in different vascular beds. It has already been shown LXA4 prolonged Plasmodium berghei-infected mice survival by mechanism depends on inhibiting IL-12 production and CD8(+)IFN-γ(+) T cells brain tissue; however, effects this treatment induced during experimental (ECM) remains be elucidated. Herein, we...

10.1016/j.intimp.2014.12.033 article EN publisher-specific-oa International Immunopharmacology 2015-01-07

Tuberculosis (TB) is one of the leading causes death worldwide and a major public health problem. Immune evasion mechanisms antibiotic resistance highlight need to better understand this disease explore alternative treatment approaches. Mycobacterial infection modulates macrophage response metabolism persist proliferate inside cell. Cannabinoid receptor type 2 (CB2) expressed mainly in leukocytes course inflammatory diseases. Therefore, our study aimed evaluate effects CB2-selective agonist...

10.1093/jleuko/qiae246 article EN Journal of Leukocyte Biology 2024-11-14

The present study isolated three major active flavonoids, two flavones named 4’,5,7‐trimethoxy‐luteolin (1) and 6‐hydroxy‐5,7‐dimethoxyflavone (2) the flavanone 5‐hydroxy‐6,7‐dimethoxyflavanone (3) from Zeyheria montana dichloromethane leaf extract. Isolation purification were conducted with application of column chromatography structures assigned by spectral analysis. All compounds evaluated for cytotoxic activities against human tumor cell lines UACC‐62 (melanoma), MCF‐7 (breast),...

10.1002/ptr.3438 article EN Phytotherapy Research 2011-02-24

Abstract Background Some multifunctional cellular proteins, as the monocyte chemotactic protein-induced protein 1 (ZC3H12A/MCPIP1) and cyclin-dependent kinase inhibitor CDKN1A/p21, are able to modulate susceptibility human immunodeficiency virus type (HIV-1). Several studies showed that CDKN1A/p21 is expressed at high levels ex vivo in cells from individuals who naturally control HIV-1 replication (HIC) a recent study supports coordinate regulation of ZC3H12A/MCPIP1 transcripts model renal...

10.1186/s12977-020-00522-4 article EN cc-by Retrovirology 2020-07-02

Zeyheria montana is a medicinal plant used in Brazilian folk medicine for treating skin affections, ulcers, inflammation and diarrhoea, as an antisyphilitic antiblenorrhagic agent, but little known about its mechanisms of action. Herein, bio-guided assay was carried out to further evaluate antioxidant immunomodulatory effects, the possible benefits on experimental intestinal inflammation.Extracts, partitions, fractions isolated compounds were tested inhibition lipid peroxidation. Isolated...

10.1111/jphp.12354 article EN Journal of Pharmacy and Pharmacology 2014-12-31

Austroplenckia populnea (Reiss.) Lund. is a Brazilian Cerrado plant belonging to the Celastraceae family. Hexane and methanol extracts of leaves were investigated for their antiulcerogenic (ethanol indomethacin/bethanecol induced gastric damage) analgesic (writhing tail-flick tests) activities in mice. Acute toxic effects also evaluated. Oral administration both at dose 1000 mg/kg significantly reduced total area lesion, relative lesion ulcerative index ethanol-induced damage, but inactive...

10.1002/ptr.932 article EN Phytotherapy Research 2002-03-01

Nuclear factor kappa B (NF-κB) plays critical roles in the regulation of many pathophysiological processes, including inflammation and immune responses, cell growth apoptosis. This DNA-binding protein receptor is considered an important molecular target to treat diseases through host-directed therapy. In this line, several drugs containing thiophene cores have been extensively evaluated due their ability interfere on NF-κB translocation nucleus. work, assays using drug affinity responsive...

10.1080/07391102.2018.1552623 article EN Journal of Biomolecular Structure and Dynamics 2018-11-29

Abstract Glioblastoma is the most invasive and malignant brain tumor, for which no effective treatment currently available. Heat shock protein 90 (HSP90) a potential target of different types cancer. Herein, we investigated effect gedunin, an HSP90 inhibitor, in murine GL261 glioblastoma vitro vivo models. Gedunin decreased cell proliferation triggered apoptosis concentration- dependent manner. also reduced migration metalloproteinase-2 activity, suggesting that it impairs invasion. Despite...

10.1101/2023.06.02.543101 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2023-06-05

Abstract Chronic myeloid leukemia (CML) is a myeloproliferative disease, characterized by the presence of oncogene BCR-ABL. Imatinib mesylate (IMA) first-line treatment for CML, and some resistance has been reported. Natural products are rich sources bioactive compounds with biological effects, opening possibility to alter cell susceptibility drugs such as imatinib. Herein, we evaluated interference betulinic acid ursolic in glycoprotein P (P-gp) activity possible synergistic effect when...

10.1055/a-2440-4847 article EN Planta Medica 2024-10-12
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