A5011135978- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
- Bioactive Compounds and Antitumor Agents
- Essential Oils and Antimicrobial Activity
- Ion Channels and Receptors
- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Venomous Animal Envenomation and Studies
- Inflammatory mediators and NSAID effects
- Healthcare and Venom Research
- Genomics, phytochemicals, and oxidative stress
- Dermatology and Skin Diseases
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Exercise and Physiological Responses
- Glutathione Transferases and Polymorphisms
- Seaweed-derived Bioactive Compounds
- Medicinal Plants and Bioactive Compounds
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Chromatography in Natural Products
- Free Radicals and Antioxidants
- NF-κB Signaling Pathways
- Morinda citrifolia extract uses
- Cancer, Stress, Anesthesia, and Immune Response
Universidade Estadual de Londrina
2014-2023
Vanillic acid (1) is a flavoring agent found in edible plants and fruits. It an oxidized form of vanillin. Phenolic compounds substantial part plant foods used as antioxidants with beneficial biological activities. These have received considerable attention because their role preventing human diseases. Especially, 1 presents antibacterial, antimicrobial, chemopreventive effects. However, the mechanisms by which exerts its anti-inflammatory effects vivo are incompletely understood. Thus,...
In the present study, effect and mechanism of action flavonoid naringenin were evaluated in superoxide anion donor (KO2)-induced inflammatory pain mice. Naringenin reduced KO2-induced overt-pain like behavior, mechanical hyperalgesia, thermal hyperalgesia. The analgesic depended on activation NO−cGMP−PKG−ATP-sensitive potassium channel (KATP) signaling pathway. also neutrophil recruitment (myeloperoxidase activity), tissue oxidative stress, cytokine production. Furthermore, downregulated...
Cytokines and reactive oxygen species are inflammatory mediators that lead to increased sensitivity painful stimuli, their inhibition represents a therapeutic approach in controlling acute chronic pain. The water-soluble flavonone hesperidin methyl chalcone (HMC) is used the treatment of venous diseases, but its bioactivity as anti-inflammatory analgesic poorly understood. present study evaluated protective effects HMC widely mouse models prolonged inflammation Male Swiss mice were treated...
Background and Purpose Gouty arthritis is characterized by an intense inflammatory response to monosodium urate crystals (MSU), which induces severe pain. Current therapies are often ineffective in reducing gout‐related Resolvin D1 (RvD1) a specialized pro‐resolving lipid mediator with anti‐inflammatory analgesic proprieties. In this study, we evaluated the effects mechanisms of action RvD1 experimental mouse model gouty arthritis, aim that was not pursued previously literature. Experimental...
It is currently accepted that superoxide anion (O2•−) an important mediator in pain and inflammation. The role of inflammation has been mainly determined indirectly by modulating its production inactivation. Direct evidence using potassium (KO2), a donor, demonstrated it induced thermal hyperalgesia, as assessed the Hargreaves method. However, remains to be whether KO2 capable inducing other inflammatory nociceptive responses attributed anion. Therefore, present study, we investigated...
Chikungunya virus is an arthropod-borne infectious agent that causes fever disease. About 90% of the infected patients experience intense polyarthralgia, affecting mainly extremities but also large joints such as knees. Chronic disease symptoms persist for months, even after clearance from blood. Envelope proteins stimulate immune response against virus, becoming important therapeutic target. We inactivated (iCHIKV) and produced recombinant E2 (rE2) protein three different types anti-rE2...
Probucol 4,4'- (Isopropylidenedithio)bis(2,6-di-tert-butylphenol) is a synthetic molecule clinically used for prevention and treatment of hypercholesterolemia atherosclerosis. Recent studies have shown that the beneficial effects probucol mainly derive from its anti-inflammatory antioxidant properties. Gram-negative bacteria are common infectious agents their wall components, e.g. lipopolysaccharide (LPS), important elicitors inflammation. LPS sensed by tissue resident cells it triggers...
Lipoxin A4 (LXA
O gengibre (Zingiber officinale Roscoe) vem sendo utilizado tanto na medicina natural tradicional quanto contemporânea, descritos mais de 115 componentes do fresco e seco. Dentre esses componentes, os compostos fenólicos, gingerol o shoagol, têm sido amplamente estudados apresentando diferentes propriedades destas moléculas como efeito antipirético, analgésico, inibidor da angiogênese, atividades imunomoduladoras, entre outras. Esta revisão tem objetivo apresentar assim seu antagônico sobre...
Arthroplasty is an orthopedic surgical procedure that replaces a dysfunctional joint by prosthesis, thereby restoring function. Upon the use of wearing process begins, which releases components such as titanium dioxide (TiO2) trigger immune response in periprosthetic tissue, leading to arthritis, arthroplasty failure, and need for revision. Flavonoids belong class natural polyphenolic compounds possess antioxidant anti-inflammatory activities. Hesperidin methyl chalcone’s (HMC) analgesic,...